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Test–Retest Repeatability of Brain Oxygen Metabolism Measurement using MRI
Chunwei Ying1, Michael M. Binkley2, Peter Kang2, Yasheng Chen2, Jin-Moo Lee2,3, Andria L. Ford2, and Hongyu An3
1Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States, 2Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States, 3Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States
Background suppressed 3D pCASL had better test-retest repeatability than 2D pCASL, especially in watershed region. OEF measured with ASE had better repeatability than CBF measured with pCASL.  CMRO2 had similar test-retest repeatability to CBF.
Figure 4. Inter-session repeatability of OEF, CBF and CMRO2 in WB, GM, WM and WS regions. The red horizontal line, dotted black horizontal lines, and solid black horizontal lines represent the mean, ± SD, and ± 1.96xSD of inter-session measurement differences, respectively.
Figure 2. Gray matter (A), white matter (B) and watershed region mask (C), OEF map (D), CBF maps (E) and corresponding CMRO2 maps (F) from a representative subject.