Clinical Phenotype Polymorphism of Ischemic Stroke Underpinned by Inter-network Functional Connectivity
Lijuan Zhang1, Siqi Cai1,2, Chunxiang Jiang1,2, Shihui Zhou1,2, and Li Yi3
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Peking University Shenzhen Hospital, Shenzhen, China
Divergent inter-network connectivity patterns were identified in stroke patients with unilateral motor deficit, indicating a polymorphism of the clinical phenotype of stroke. This study provides new insight into better itemization of the disease
dynamic and management of ischemic stroke.
Functional connectogram (A-C) and group averaged
functional connectivity (FC) matrix (D-F) of healthy controls (HC) and two
clusters of subjects with stroke. Asterisk (*) indicates significant
differences between the patient clusters (Two-sample t-test,
p<0.05, FDR correction). Comment sign (#) indicates significant
difference between either cluster and HCs (Two-sample t-test, p<0.05, FDR
correction).