Greg O Cron1, Rafael Glikstein2, Jean Francois Thibodeau3, Anthony Carter3, Chet E Holterman3, Alexey Gutsol3, Lihua Zhu3, Baptiste Lacoste3, and Chris Kennedy3
1Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada
1Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada
We hypothesized that hypertension predisposes rats to low-dose aspirin induced kidney and cerebrovascular injury. Results showed that these rats appeared to have decreased cerebral blood flow and significant kidney and cerebrovascular injury.
Whole-brain cerebral blood flow in rats at +4 and +8 weeks post treatment, for the four groups studied.
Urinary albumin levels, measured by ELISA, as a surrogate of kidney injury. Higher values suggest more kidney injury.
