S59
Assessing the reproducibility of semi-automated segmentation methods on post-operative T1 post contrast and FLAIR MRI of GBM.
Olga V Fadeeva Da Costa1,2, Shah Islam2,3, Mark M Boubnovski3, Eric Aboagye3, and Adam D Waldman4,5
1Department of Surgery & Cancer, Cancer Imaging Centre, Hammersmith Campus, Imperial College, London, United Kingdom, 2Imaging Department, MRI Unit, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom, 3Department Of Surgery & Cancer, Cancer Imaging Centre, Hammersmith Campus, Imperial College, London, United Kingdom, 4Department of Brain Sciences, Hammersmith Campus, Imperial College, London, United Kingdom, 5Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
The primary purpose of this study was to quantify the inter and intra reader reproducibility of segmentation of postoperative MRIs in patients with GBM.  Accurate delineation and analysis of disease residuum is important for clinical trial endpoints and image biomarker development. 
Table 1: Summary of reproducibility of segmentation voxels and their respective volumes