ISMRM & SMRT Annual Meeting • 15-20 May 2021

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Weekend Course

Statistics for MRI

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Statistics for MRI
Weekend Course
ORGANIZERS: Daniel Gallichan, Fernando Calamante
Saturday, 15 May 2021
Concurrent 4 13:45 -  14:30 Moderators: Irena Zivkovic & Woojin Jung
Skill Level: Basic to Intermediate
Session Number: WE-08
Parent Session: Statistics for MRI

Session Number: WE-08

Overview
This half-day Educational course will provide an introduction to statistical methods for imaging studies. The course will focus on concepts of study design and data analysis that are frequently used in imaging studies. Topics to be covered include prospective and retrospective studies, error rates and hypothesis testing, ROC curves, basic sample size calculations, methods for evaluating quantitative imaging biomarkers, and statistical concepts in radiomics analysis.

Target Audience
Radiologists, scientists, medical physicists, engineers, and clinicians who would like an overview of the foundations of study design and statistical analysis methods focused on imaging tests.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe different study designs;
- Apply basic statistical methods for evaluating imaging tests;
- Identify the information necessary to perform sample size calculations; and
- Identify key concepts and biases in radiomics analyses.

    Designing Studies of Diagnostic Imaging
Video Permission Withheld
Susan Mallett
This session introduces key concepts in designing imaging studies to measure diagnostic test accuracy and how to put answering your clinical question at the heart of the study design.
  Basic Concepts in Measurement Error

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Alice Sitch

This session introduces the concept of measurement error and considers the key questions: What is ‘measurement error’? and Why do we need to estimate ‘measurement error'? An example of a liver fibrosis monitoring study is used to introduce the key information and the generic design for imaging studies is also considered.

 

    Study Designs & Bias
Video Permission Withheld
Susan Mallett
This session introduces how you can use risk of bias checklists to help you identify key design features needed for your imaging study.
  Monitoring Studies

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Alice Sitch

This session follows on from introducing the concept of measurement error and considers the key questions: What are monitoring studies? How can tests impact patients? And how can monitoring strategies be planned?

This session introduces the concept of monitoring strategies and demonstrates how these can be planned with knowledge of the measurement error of tests.

  Understanding Variability Including Interreader & Intrareader Studies

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Alice Sitch

This session follows on from introducing the concept of measurement error and monitoring studies and considers the key questions: How are real variability studies conducted? And how can variability estimates help us plan test evaluation studies?

This session reviews the design and results of studies used to estimate inter and intra reader variability and the impact of these results on further test evaluation studies.

    Advanced Methods & Reporting
Video Permission Withheld
Susan Mallett
This session helps you report your study so it is useful to others including: using reporting guidelines from the EQUATOR network website; usefulness of reporting raw study data, understanding which units are important in your analysis. Issues in test thresholds and ROC AUC are discussed, and reporting study results in natural numbers to aid comprehension.

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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.