ISMRM25 - New Insights in Flow-Related Methods

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

New Insights in Flow-Related Methods

Digital Poster

Contrast Mechanisms

Tuesday, 13 May 2025

Exhibition Hall

09:15 - 10:15

Session Number: D-101

No CME/CE Credit

		Computer Number: 49 2468. Effects of acetazolamide and caffeine on blood-brain-barrier water permeability measured by non-invasive ASL-based MRI sequences View Presentation Video J. D. Fernandes, K. Baas, L. Václavů, B. Padrela, M. Caan, B. Biemond, A. Nederveen, J. Wood Amsterdam UMC, Amsterdam, Netherlands Impact: We demonstrate that the expected physiological effects of caffeine and acetazolamide on brain oxygen extraction fraction, perfusion and BBB function were captured on spin-labeling-based techniques. Combining these drugs and MR-sequences could be useful for research evaluating therapies in neurological disorders.
		Computer Number: 50 2469. SENSITIVITY ASSESSMENT OF QSM+qBOLD (or QQ) IN DETECTING ELEVATED OXYGEN EXTRACTION FRACTION (OEF) IN PHYSIOLOGICAL CHANGE View Presentation Video P. Elanghovan, T. Nguyen, P. Spincemaille, Y. Wang, J. Cho The State University of New York at Buffalo, Buffalo, United States Impact: This study demonstrates QQ’s sensitivity to physiologically increased OEF during hyperventilation. With high OEF expected in various cerebrovascular disorders, including vascular dementia and Parkinson’s disease, this finding suggests that QQ can help in understanding abnormal brain metabolism in such disorders.
		Computer Number: 51 2470. Real-time EPI-based phase-contrast MRI for the measurement of cerebrovascular reactivity View Presentation Video D. S. Sankaralayam, J. Wu, C. Xu, T. Akinwale, P. Liu, H. Lu Johns Hopkins University School of Medicine, Baltimore, United States Impact: This study could establish a quicker, more accessible real-time method for cerebrovascular reactivity assessment, improving early diagnosis and personalized monitoring of cerebrovascular conditions, especially for cognitive impairment and small vessel disease in clinical and research settings.
		Computer Number: 52 2471. Study of flow dynamics in realistic aneurysm phantom with 4D flow MRI, Optical Transmission (OT), and Magnetic Particle Imaging (MPI) View Presentation Video T. Reichl, A. el Ahmar, T. Kampf, J. Günther, M. A. Rückert, T. A. Bley, S. Herz, V. C. Behr, S. Schnell, P. Winter, P. Vogel Julius-Maximilians University Würzburg, Würzburg, Germany Impact: Three modalities, 4D flow MRI, OT and MPI were used to visualize and compare the flow dynamics in realistic aneurysm phantoms with good agreement. The vessel curvature was found to strongly influence the flow dynamics.
		Computer Number: 53 2472. Inherent velocity encoding in EPI-based phase contrast MRI using a modified flyback approach View Presentation Video S. Blömer, R. Stirnberg, T. Stöcker Deutsches Zentrum für Neurodegenerative Erkrankungen, Bonn, Germany Impact: Interleaved flyback EPI achieves velocity encoding through the readout gradients rather than Venc gradients and simultaneously addresses key limitations of conventional EPI-based Venc. If shown to match gold-standard accuracy, it could reduce acquisition times by one-third.
		Computer Number: 54 2473. Composite Spin Probes with Adjustable Oxygen Sensitivity for Pulse EPR Imaging View Presentation Video I. Canavesi, N. Viswakarma, R. Khurana, B. Epel, P. Kuppusamy, M. Pagel, M. Kotecha O2M Technologies, LLC, Chicago, United States Impact: We developed novel robust solid composite probes with adjustable oxygen sensitivity that allow pO₂ imaging using pulse EPRI in full physiological range. Solid probe imaging will provide new insights where repeated and frequent oxygen measurements are needed.
		Computer Number: 55 2474. Characterization of Turbulence and Pressure Gradients in Venous Sinus Stenosis: A Phantom Study using 4D Flow MRI with ICOSA6 Encoding and vWERP-t View Presentation Video J. Schollenberger, H. Ali, K. Valluru, M. Amans, D. Nordsletten, D. Saloner, D. Marlevi University of California - San Francisco, San Francisco, United States Impact: This work demonstrates the feasibility of measuring turbulence-driven pressure gradients in venous sinus flows non-invasively, laying the groundwork for future in-vivo studies to investigate the relationship between pulsatile tinnitus and venous sinus hemodynamics.
		Computer Number: 56 2475. Cerebral blood volume mapping using hyperoxia and oxygenation-sensitive MRI is robust to O2-induced hypocapnia View Presentation Video G. Hoffmann, E. Saks, N. Blockley, C. Zimmer, C. Preibisch, S. Kaczmarz Technical University of Munich, Munich, Germany Impact: This study supports hyperoxia (HOX) BOLD-fMRI as promising for non-invasive CBV-mapping. Despite moderate HOX-induced hypocapnia, CBV remained stable. Thus HOX-CBV may enhance neuroscientific research, especially for quantitative BOLD-fMRI. Also, it may facilitate clinical imaging in patients with contrast-agent contraindications.
		Computer Number: 57 2476. Calf muscle oxygen extraction fraction measurement using the multi contrast EPI with keyhole sequence – feasibility study. View Presentation Video M. Wylezinska-Arridge, C. Pizzamiglio, F. Küppers, N. J. Shah, L. Mancini, D. Thomas, R. Pitceathly, J. Thornton National Hospital for Neurology and Neurosurgery, London, United Kingdom Impact: This work supports the feasibility of using a recently developed multi contrast EPI with keyhole sequence to quantify T2, T2* and oxygen extraction fraction in skeletal muscle. This could prove a valuable tool for studying oxygen metabolism in muscles in health and disease.
		Computer Number: 58 2477. MRI 4D-flow virtual Work-Energy analysis of pulmonary arterial vortical flow and pressure reversal in pulmonary hypertension View Presentation Video R. Karim, A. Fyrdahl, J. Ramos, M. Melin, P. Sundblad, D. Marlevi, B. Wieslander Department of Clinical Physiology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden Impact: Our results contribute to elucidating the mechanistic link between pulmonary hypertension and vortical blood flow in the pulmonary artery, which may in turn inform the appropriate clinical role of 4D-flow MRI in pulmonary hypertension.
		Computer Number: 59 2478. An Optimal, Routinely Applicable Multi-Echo Gradient Echo (mGRE) Data Acquisition Scheme for QQ-based Oxygen Extraction Fraction (OEF) Mapping View Presentation Video A. Misra, J. Cho State university of new York at buffalo, Buffalo, United States Impact: The proposed sampling scheme requires no additional modifications to the routine mGRE sequence, it can be therefore readily applied in clinical settings, enhancing the detection of lesion abnormalities.
		Computer Number: 60 2479. Comparison of MR-based oximetry for whole-brain oxygen extraction fraction in adults with sickle cell disease View Presentation Video Y-H Chen, P-H Wu, S. Chawla, F. Sayani, J. E. Russell, F. W. Wehrli, S. A. Nabavizadeh National Sun Yat-sen University, Kaohsiung, Taiwan Impact: SBO and T2O are in good agreement in OEF estimation, in excellent consistence with the trend reported for healthy subjects.
		Computer Number: 61 2480. Multi-Echo versus T2-Prepared pCASL: what to use for measuring water transport across the Blood Brain Barrier View Presentation Video H. Durrant, M. J. van Osch, L. Václavů Leiden University Medical Center, Leiden, Netherlands Impact: This work informs the community about which multi-TE ASL sequence should be used for BBB water transport measurements. Moreover, it highlights potential pitfalls and inaccuracies associated with the sequences, which will help to provide more reliable interpretation of future results.
		Computer Number: 62 2481. Venous oxygenation measurements in the upper arm: reproducibility and sensitivity to a physical challenge View Presentation Video J. D. Fernandes, K. Baas, J. Wood, M. Caan, B. Biemond, A. Nederveen Amsterdam UMC, Amsterdam, Netherlands Impact: The optimized TRUST sequence enables fast-T2b measurements in upper arm veins, allowing accurate, disease-specific venous calibration curves via a-posteriori blood characteristic correlation. This may improve oxygenation assessment using TRUST in various patient groups, providing a tool to investigate pathological mechanisms.
		Computer Number: 63 2482. Non-contrast MR imaging of blood-brain barrier permeability to water at 5T: Improved reliability compared to 3T View Presentation Video S. Yu, S. Chen, P. Sui, Q. Xu, N. Yang, X. Ye, X. Zhang, J. Zhu, H. Lu, X. Zhao, Z. Lin Tsinghua University, Beijing, China Impact: We proposed a WEPCAST imaging protocol at 5T that provided a superior performance in BBB assessment when compared to 3T, highlighting the potentials of 5T MRI in physiological imaging of the brain.
		Computer Number: 64 2483. A comparison of gas-free MRI methods for CMRO2 quantification in primary brain tumour View Presentation Video S. Zappalà, E. Patitucci, J. Powell, S. Iqbal, F. Küppers, J. Shah, R. Wise, M. Germuska Cardiff University, Cardiff, United Kingdom Impact: Common implementations for gas-free CMRO₂ quantification do not account for non-blood susceptibility sources. This is demonstrated to be problematic for an R₂’ based qBOLD implementation in primary brain tumour, where haemorrhage and iron deposition can occur concurrently with metabolic changes.

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