Digital Poster
Diffusion DWI/DTI/DKI
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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Computer Number: 65
4491. Investigating
the Mechanism of Inositol Against Paclitaxel Chemoresistance on
TNBC by Using 7T Multiparametric MRI and Mitochondrial Changes
W. Xuan, W. Li, L. Ke, Y. Shen, X. Zhang, Y. Chen, Z. Ye, C.
Zhuang, S. Xie, R. Wu, Y. Lin
The Second Affiliated Hospital of Shantou University Medical College, Shantou, China
Impact: The findings suggest that inositol could become
a novel therapeutic strategy for overcoming PTX resistance
in TNBC, potentially guiding future research on
mitochondrial-targeted treatments. This could lead to
improved clinical outcomes for patients with drug-resistant
breast cancer.
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Computer Number: 66
4492. Diffusion
tensor metrics in regions functionally activated in
resting-state fMRI for a test cohort with multiple sclerosis
W. Mazur-Rosmus, A. Słowik, A. Krzyżak
AGH University of Krakow, Krakow, Poland
Impact: The proposed approach showed potential for the
use of DTI metrics in the assessment of the grey matter
structure change due to MS specifically in rs-fMRI
activation areas and for BSD to improve quantitative
parametrization of MS.
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Computer Number: 67
4493. Fiber
Microstructure Quantile (FMQ) Regression: A Novel Statistical
Approach for Analyzing White Matter Bundles from Periphery to
Core
Z. Lan, Y. Chen, J. Rushmore, L. Zekelman, N. Makris, Y.
Rathi, A. Golby, F. Zhang, L. O’Donnell
Brigham and Women's Hospital, Boston, United States
Impact: This study provides a novel perspective on white
matter microstructure and its functional implications, which
can guide future research on brain development and
interventions for neurological disorders.
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Computer Number: 68
4494. Structural
and microstructural characterization of corpus callosum
integrity in paediatric-onset Huntington Disease
M. C. Bonacci, M. E. Caligiuri, F. Squitieri, U. Sabatini
University Magna Graecia, Catanzaro, Italy, Catanzaro, Italy
Impact: This study provide first characterization of
micro- and macrostructural alterations in POHD along the CC.
Measures were compared between POHD and age- and sex-matched
healthy-controls (PHC) as well as adult-onset HD(AOHD), to
explore the differential involvements of these fibre tracts.
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Computer Number: 69
4495. Improved
image quality of DWIBS at 1.5T using a combination of slice
selection gradient reversal and broadband STIR pulse
D. Murayama, M. Yoneyama, T. Sakai, I. Ball
Eastern Chiba Medical Center, Chiba, Japan
Impact: Our study demonstrated that the modified DWIBS
with a combination of broadband STIR pulse and SSGR
significantly improved image quality, especially for
improving the fat suppression and reducing the zebra
artifacts, even at the 1.5T clinical system.
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Computer Number: 70
4496. Identifying
Early Diffusion MRI Biomarkers in 2-month-old 3xTg-AD mice via
the Elastic Net
M. d. F. Falangola, B. Granger, J. Voltin, P. Nietert, S.
Berto, J. Jensen
Medical University of South Carolina, Charleston, United States
Impact: Diffusion MRI can accurately distinguish 3xTg-AD
mice from control mice at 2 months, which is prior to the
development of amyloid plaques and tau pathology. This
demonstrates dMRI’s high sensitivity to microstructural
changes occurring early in the disease process.
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Computer Number: 71
4497. Correlation
between multi-parameter MRI and Gleason score in prostate cancer
using point-to-point irradiation analysis
X. Zhao, X. Ya, L. Kong, X. Yang, K. Meng, Y. Meng, C.
Zhang, B. Wang, Z. Kong
the Second Affiliated Hospital of Dalian Medical University, Dalian, China
Impact: The proposed quantitative parameter, based on
prostate cancer/obturator internus muscle signal intensity,
enables noninvasive prostate cancer diagnosis and eliminates
the need for biopsy.
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Computer Number: 72
4498. Efficacy
of IVIM in differentiating invasive micropapillary carcinoma and
fibroadenoma with rapid rising TIC curve
Y. Wu, L. Zhang, S. Zhao, Y. Li, M. Zhang, D. Zheng, L. Lin
The First Affiliated Hospital of Dalian Medical University, Dalian，China, China
Impact: The ADC (b=1000 s/mm²) and D value derived from
IVIM model are helpful to provide quantitative information
for the differentiation of rapid-rising TIC IMPC from
fibroadenoma.
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4499. WITHDRAWN |
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Computer Number: 73
4500. Resting-State
fMRI Global Small-World Network as a Mediator Between Glymphatic
System and Cognitive Function in Minimal Hepatic Encephalopathy
Q. Zhang, Z. Xiong, L. Nie, M. Zhong, R. Wang
Guizhou Provincial People’s Hospital, Guiyang, China
Impact: The discovery of reduced glymphatic system
activity and diminished brain network efficiency offers
valuable insights into potential mechanisms underlying MHE.
These findings may aid in developing targeted therapies for
MHE, ultimately enhancing patient care and outcomes.
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Computer Number: 74
4501. Potential
of Apparent Diffusion Coefficient values in Solitary Pulmonary
Nodules Imaging at Low-Field MR: A 0.55/1.5T Scanner Comparison
S. Ma, R. Nai, J. Yang, J. Liu, W. Li, X. Wang, J. Qiu
Peking University First Hospital, Beijing, China
Impact: ADC cut-offs of 0.55T MRI can be feasibly
integrated into clinical suspected SPNs
interpretations, demonstrating the potential to decrease
overall biopsies in future while further valid
conclusions are still needed through well-designed and
larger clinical trials.
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Computer Number: 75
4502. Investigating
diffusion MRI biomarkers in the brain of adults with
attention-deficit hyperactivity disorder
E. Uren, M. Tayebi, X. Zhao, E. Kwon, C. Saludar, J.
Fernandez, V. Shim
The University of Auckland, Auckland, New Zealand
Impact: These findings highlight the potential for
diffusion MRI to provide a more detailed, neurobiologically
grounded approach to ADHD diagnosis, which could lead to
earlier and more targeted interventions, improving long-term
outcomes for affected individuals.
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Computer Number: 76
4503. Artifacts-Free
Multi-Shot Liver Diffusion Weighted Imaging with Phase
Constrained Reconstruction
M. Han, Q. Cai, L. Li, R. Song, Y. Wang, X. Jiang, Q. Xu, X.
Qu
Xiamen University, Xiamen, China
Impact: The propose method can eliminate motion
artifacts and improve the SNR of reconstructed images. The
successful application of this method is expected to enable
liver DWI to play a greater role in early diagnosis and
efficacy evaluation of clinical diseases.
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Computer Number: 77
4504. Assessing
Glymphatic Function Alterations in Gliomas: DTI-ALPS as a
Potential Biomarker for Tumor Characteristics and Survival
Analysis.
Q. Li, R. Zhong, X. Li, X. Zhang, H. Wang, Z. Hu, N. Zhang
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, ShenZhen, China
Impact: This study emphasizes a significant connection
between glymphatic function changes, tumor characteristics,
and survival prognosis, providing a radiological basis for
further neuro-oncological research on the glymphatic system.
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Computer Number: 78
4505. Navigator-based
slice tracking for multiband accelerated liver DWI
K. Zhang, S. Triphan, C. Ziener, M. Ladd, H-P Schlemmer, H-U
Kauczor, O. Sedlaczek
Heidelberg University Hospital, Heidelberg, Germany
Impact: This study demonstrates the feasibility of a NAV
technique to reduce respiratory motion in multiband
accelerated liver DWI.
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Computer Number: 79
4506. Gray
matter Abnormalities in Systemic Lupus Erythematosus Patients
without Neuropsychiatric Symptoms: A Multi-shell Diffusion
Imaging Study
W. Hu, Z. Qiu, F. Wu, X. Zhang, X. Tan
Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, Chin, Guangzhou, China
Impact: This study provides a comprehensive
understanding of gray matter changes and pinpoints the most
affected regions in SLE. The combination of DKI and NODDI
models presents optimal diagnostic efficacy.
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