Digital Poster
Diffusion DWI/DTI/DKI II
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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Computer Number: 81
4665. Application
of diffusion kurtosis imaging for differentiating T0-T1 from T2
rectal tumors
Y-r MA, S-p YU, H-d QIN, Y. CHEN
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Impact: Diffusivity obtained from DKI has the potential
to serve as a biomarker for early rectal tumor assessment,
providing valuable information for selecting appropriate
patients for organ preservation surgery.
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Computer Number: 82
4666. Repeatability
and reliability of Diffusion Tensor Imaging in white matter
rectified with free-water
T. Pieciak, G. París, S. Aja-Fernández, R. de Luis-García,
A. Tristán-Vega
Universidad de Valladolid, Valladolid, Spain
Impact: This result for multiple-shell
diffusion MRI data opposes previous studies on single-shell
data (Hum. Brain Mapp., 38(1), 2017), which suggest
that correcting the DTI for FW via direct
optimization of bi-tensor representation improves
repeatability.
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Computer Number: 83
4667. Comparative
Evaluation of Deep Learning-Reconstructed FOCUS-MUSE, MUSE,
FOCUS, and SS-DWI for Bladder Imaging
P. Fan, E. Guo, Y. Zhang, B. Hou, F. Feng, G. Zhang, H. Sun
Peking Union Medical College Hospital, Beijing, China
Impact: Offers insights into selecting optimal diffusion
sequences for bladder imaging under deep learning-based
reconstruction, enhancing clinical efficiency and accuracy.
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Computer Number: 84
4668. Impaired
Glymphatic System Function in Sleep-Deprived Individuals
demonstrated by DTI-ALPS Index
Y. Zhao, X. Dai, W. Huang, L. Han, P. Wu, W. Xiao
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Impact: In conclusion, the DTI-APLS index may have the
potential to assess the impaired function of the glymphatic
system in sleep deprived individuals.
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Computer Number: 85
4669. FOCUS-MUSE
and MUSE Diffusion-Weighted Imaging: A Comparative Study in
Gastric Cancer Imaging
Q. Li, P-Y Wu
the First Affiliated Hospital with Nanjing Medical University, Nanjing, China
Impact: The FOCUS MUSE DWI is a better imaging protocol
for the T staging assessment of gastric cancer patients,
compared with the MUSE DWI.
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Computer Number: 86
4670. Altered
White Matter Microstructure in Children with ADHD: Insights from
Diffusion Kurtosis Imaging and Tract-Based Spatial Statistics
S. Liu, Y. Lu, S. Li, L. Feng, L. Zhou, C. Wang, Y. Shen, X.
Zhang, X. Zhao
The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: The study reveals that children with ADHD have
reduced white matter integrity, particularly in the corpus
callosum and right cingulum. These findings suggest that
impaired information transfer in the brain may contribute to
ADHD symptoms, aiding early diagnosis and intervention.
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Computer Number: 87
4671. Submillimeter
whole-brain diffusion tensor imaging reveals radial diffusion
alterations of cortical gray matter in schizophrenia
X. Li, J. Zeng, N. Liu, H. Liang, W. Zhang, S. Lui*
Department of Radiology, West China Hospital of Sichuan University, Chengdu, China
Impact:
The altered radiality index values observed in schizophrenia patients through submillimeter DTI techniques reveal diffusion-related microstructural changes in cortical grey matter and may serve as potential biomarkers for psychopathological conditions. |
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Computer Number: 88
4672. Glymphatic
system impairment causes clinical disability through the
accumulation of tissue damage in multiple sclerosis
Z. Wang, X. Xu, W. Ren, J. Zhang, K. Ai
The Second Hospital & Clinical Medical School, Lanzhou University, Lan Zhou, China
Impact: The impact of glymphatic impairment on
disability is mediated by the tissue damage
accumulation, indicating a pathological mechanism for
MS-related disability.
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Computer Number: 89
4673. The
Clinical Value of FOCUS-MUSE Diffusion-Weighted Imaging in
Cervical Cancer：A pilot study
W. Mei, W. Chen, W. Liu
Department of Radiology, Taihe Hospital, Hubei University of Medicine,Shiyan,China, ShiYan, China
Impact: FOCUS-MUSE DWI significantly enhances cervical
cancer imaging with less artifacts and improves staging
accuracy, enabling clearer differentiation between cancerous
and healthy tissue. This advancement supports more precise
treatment planning and better patient outcomes.
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Computer Number: 90
4674. Using
Neurite Orientation Dispersion and Density Imaging to Diagnose
Data-Driven Parkinson’s Disease Subtypes in Brainstem Nuclei
W-C Yang, R-J Lin, M-C Kuo, K-H Chen, Y-F Wei, H-Y Yang, J.
O. S. Goh, Y-C Shih
National Taiwan University Hospital, Taipei City, Taiwan
Impact: NODDI assists in diagnosing the data-driven PD
subtype with the most severe motor/non-motor comorbidities.
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Computer Number: 91
4675. Diffusion-Cognitive
Correlates of Cortical Cholinergic Pathways Denervation for
Early Detection of Alzheimer's disease
P. Seow, S. Hartono, D. C. C. Seow, S. K. S. Ting, W. Lee,
W. S. Li, K. P. Ng, P. H. Chai, W. J. W. Wong, S. N. Phua,
J. S. Yee, Y. T. Lim, Y. C. Shih, L. L. Chan
Singapore General Hospital, Singapore, Singapore
Impact: The findings establish biological correlates to
cognitive manifestation as objective biomarkers for early
detection of AD by mapping the NBM-cholinergic tracts with
strongest correlation. The surrogate markers aid development
of modifying therapies, and potentially discriminate MCI
subgroups for personalized management.
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Computer Number: 92
4676. Advanced
DWI Metrics Reveal Distinct Sex-Related Differences in Splenium
of Corpus Callosum White Matter
E. Bhuiyan, Q. Luo, M. Karaman, K. Wang, P-S Zhong, L.
Frey-Law, J. Ford, S. Sutherland, T. Wager, P. Sadil, M.
Johnson, M. Lindquist, R. McCarthy, A. Buvanendran, J.
Jacobs, J. Burns, X. Zhou, t. A. Consortium
University of Illinois Chicago, Chicago, United States
Impact: The A2CPS dataset reveals sex-specific
influences on advanced DWI metrics, potentially paving the
way for future biomarkers in personalized pain management
and an enriched understanding of brain function.
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Computer Number: 93
4677. Cognitive
impairment is associated with glymphatic system dysfunction and
whole-brain white matter damage in type 2 diabetes mellitus
P. Hu, J. Dai, X. Tang
Department of Radiology, The Second Clinical Medical College of Nanchang University, Nanchang, China
Impact: For the first time, we showed the potential
interplay among brain wide WM damage, GLS dysfunction, and
cognitive impairment in T2DM patients. Our study may provide
evidence for taking GLS and brain WM into account for MCI
T2DM patients treatment.
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Computer Number: 94
4678. Inter-scanner
reproducibility of DTI parameters in WM tracts using TractFinder
across three MRI scanners of the same type
A. Sierhej, M. Hall, N. Smith, K. Seunarine, J. Clayden, M.
Correia, C. J. Evans, C. Clark
University College London, London, United Kingdom
Impact: DTI-derived FA and MD have excellent
reproducibility (ICC ≥ 0.95) across three scanners of the
same type when WM tract ROIs are automatically segmented.
This allows neuroimaging studies to use multi-centre DTI
data with confidence.
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Computer Number: 95
4679. Mapping
White Matter Degeneration in iTTP Survivors: A Diffusion Tensor
Imaging Study
F. Hannan, S. Poirier, C. Patriquin, K. Pavenski, J.
Thiessen, S. Huang
University of Western Ontario, London, Canada
Impact: This study highlights the importance of
long-term neurological monitoring in iTTP survivors
demonstrating significant white matter damage linked to
cognitive decline. The findings support the notion of
exploring early interventions to preserve cognitive function
through routine neuroimaging and targeted therapies.
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Computer Number: 96
4680. Cholinergic
white matter pathway in Parkinson's disease based on multimodal
magnetic resonance imaging technology
L. Huang, X. Li, S. Bu, M. Zhao, Y. Jiang, G. Fan
the first hospital of China medical University, Shenyang, China
Impact: Multimodal MRI provides reliable, objective
markers that improve early differentiation of PD-MCI,
enabling earlier, more precise interventions and potentially
enhancing patient outcomes while reducing healthcare
burdens.
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