ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Digital Poster

Diffusion in Cancer

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Diffusion in Cancer
Digital Poster
Diffusion
Monday, 12 May 2025
Exhibition Hall
17:00 -  18:00
Session Number: D-113
No CME/CE Credit

 
Computer Number: 65
2166. Predicting Value of Multi-b-value DWI Models for Pathological Grading of Clear Cell Renal Cell Carcinoma: A Multi-scanner Study
S. Li, M. Gao, Z. Zhou, Z. Li
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Impact: This study provides valuable insights into the utility of multi-b-value DWI models for grading ccRCC, suggesting that advanced models offer limited additional benefits over mono-exponential DWI. It enables more efficient imaging choices and informs clinical decision-making in ccRCC management.
 
 
Computer Number: 66
2167. Differentiating Histological grade in breast cancer by time-dependent diffusion MRI: A Preliminary Study
S. Che, K. Ma, Y. Jiang, F. Thorsten, J. Li, X. Zhao, C. Zhou
Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Impact: This study highlights time-dependent diffusion MRI's potential for accurate, non-invasive breast cancer grading, enhancing clinical decision-making and treatment planning, and paving the way for further research into microstructural changes and applications in other cancer types.
 
Computer Number: 67
2168. Time-dependent diffusion MRI for grading uterine cervical carcinoma based on whole tumor volume: A preliminary study
Q. Zhang, Y. Jiang, X. Yu, X. Zhao
Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Impact: Time-dependent diffusion MRI, as a non-invasive technique, could provide cell microstructure parameters for differentiating tumor grade of CC from a histological point of view, which may further assist in preoperative clinical decision-making and prognosis prediction for CC.
 
Computer Number: 68
2169. Characterizing Tumor Habitats in Breast Cancer: A DKI Approach to Predicting Estrogen Receptor Expression
H. Liu, Q. Wang, Z. Mao, H. Liu, M. Wang, Y. Song, C. zhang, G. Yang
Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Impact:

This study demonstrates that diffusion kurtosis imaging can non-invasively predict estrogen receptor expression by characterizing tumor microenvironments, revealing significant relationships between tumor habitats and their microstructural properties.

 
Computer Number: 69
2170. Differentiation of early-stage endometrial carcinoma from benign endometrial lesions: A comparative study of six diffusion models
Q. Bi, K. Wu, S. Wang, Y. Wu
The First People’s Hospital of Yunnan Province, Kunming, China
Impact: Together, diffusion parameters and the combined model could become a new and non-invasive diagnostic biomarker for differentiating benign and malignant endometrial lesions.
 
Computer Number: 70
2171. Oscillating Gradient Diffusion-Weighted MRI For the Assessment of Breast Lesions
W. Tang, Y. Guo, Z. Zhong, X. Xu, Y. Chen, Y. Xu, X. Wei
Guangzhou First People’s Hospital, Guangzhou, China
Impact: Oscillating gradient DWI, with shorter diffusion times, complements conventional pulsed gradient DWI by revealing additional tumor microstructural details. Combined OGSE and PGSE sequences may enable novel diffusion-based biomarkers for improved breast lesion characterization and stratification.
 
Computer Number: 71
2172. Generative Adversarial Network (GAN)-based High-Fidelity Diffusion Tensor Imaging in Brain Cancer Patients
I. Guha, H. Ravi, R. Mohamed, C. Quarles, H-L Liu
MD Anderson Cancer Center, Houston, United States
Impact: Our study demonstrates the potential of DL to reduce DTI scan time for brain cancer patients by enabling accurate estimation of DTI metrics from only 6-direction DWI volumes; and enhancing their image quality and signal-to-noise ratio.
 
Computer Number: 72
2173. DKI-based spatial heterogeneity analysis for tumor-infiltrating lymphocytes level in breast cancer patients
Z. Mao, H. Liu, H. Liu, M. Wang, Y. Song, C. Zhang, G. Yang
The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Impact: The stable predictive performance of DKI/TILs can help clinicians make more accurate diagnoses; commercialization is expected.
 
Computer Number: 73
2174. The Application of Time-Dependent Diffusion MRI in Clinical Staging and Pathological Differentiation of Cervical Squamous Carcinoma
J. j. Li, Y. Xiao, K. Ai, Y. Zhu, Y. Hao, J. Guo
The First Affiliated Hospital of Xi'an Jiaotong University , Xi’an, China
Impact: TDD-MRI parameters, particularly cell diameter, demonstrate superior accuracy to ADC in differentiating pathological grades and stages in CSC, supporting their use for non-invasive cervical cancer assessment.
 
Computer Number: 74
2175. Time-Dependent Diffusion MRI-based Quantitative Multiparameters for Preoperative Assessment of VETC in Hepatocellular Carcinoma
M. Li, L. Zhou, A. Abudulimu, H. Zhang, L. Qian, T. Feiweier, W. Li
Xiangya Hospital, Central South University, Changsha, Hunan Province, China
Impact: Td-dMRI is a potential tool for evaluating VETC status in HCC, which may contribute to the optimization of personalized treatment strategies for patients with HCC, thus leading to improved prognosis.
 
Computer Number: 75
2176. Optimizing MRI Cytometry: Preliminary Applications and Standard Procedure Enhancements in Cervical Cancer Diagnosis
Z. Yuan, D. Shi, F. Liu, Z. Wang, Y. He, X. Gao, Y. Li, J. Chen, X. Liu, J. Ren, H. Guo, Z. Jin, H. Xue
Radiology Department, Peking Union Medical College Hospital, Beijing, China
Impact: The MRI cytometry parameters can distinguish cervical cancer from normal cervix by directly capturing the changes in the tissue microstructure. It may further assist in preoperative risk stratification and treatment efficacy evaluation in cervical cancer in the future.
 
Computer Number: 76
2177. Distinguishing Ki67 stratification expression in ER-positive/HER2-negative breast cancers: comparison of advanced MRI diffusion models
Z. Kang, S. Du, L. Zhang
The Fourth Affiliated Hospital of China Medical University, Shenyang, China
Impact: This research reveals the utilization of FROC model improved differentiation of the low Ki67 expression group (Ki67≤ 5%) in ER+/HER2- breast cancer, who frequently exhibit a favorable prognosis and do not require excessive adjuvant chemotherapy. 
 
Computer Number: 77
2178. Detecting Cellular Microstructural Changes of Bone Tumors with the IMPULSED MRI
Y. Li, C. Ren, J. Cheng, Y. Zhang, W. Zhang, L. Lin
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Impact: This study revealed the changes in quantitative microstructural mapping across the spectrum of bone tumors. Intracellular volume fraction and cellularity are potential markers for differentiating benign and malignant bone tumors.
 
Computer Number: 78
2179. Evaluating IVIM and ADC Parameters to Differentiate Benign and Malignant Soft-Tissue Lesions
M. Marzetti, P. Robinson, L. Maguire, P. Duce, S. Klein, M. Starmans, A. Scarsbrook, D. Buckley
Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Impact:

This work uses quantitative MRI to differentiate benign from malignant soft-tissue lesions, aiming to reduce the need for soft-tissue biopsies. This could reduce the number of invasive procedures patients undergo and provide diagnoses faster, reducing patient anxiety, pain and discomfort.

 
 
Computer Number: 79
2180. Characterization of Upper Extremity Lymphedema Following Breast Cancer Treatment Utilizing Diffusion Kurtosis MRI
Y. Lee, K-H Cho, C-H Tang, Y-C Chang, I-H Lee, Y-C Hsieh, S-C Chao, C-H Kuan, L-W Kuo
National Taiwan University Hospital, Taipei, Taiwan
Impact: This study provides a quantitative approach to delineate the tissue characteristics of lymphedema by utilizing diffusion kurtosis MRI, enabling a more precise and non-invasive way to assess the severity, which could be potentially helpful to the surgical planning of lymphedema.
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