Digital Poster
Neuro Diffusion
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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Computer Number: 113
4080. MR
neurography of tibial and common peroneal nerves in patients
with Guillain-Barre syndrome and electrophysiological
correlation
J. Cao, S. Wang, W. Zheng, G. Wang
Zibo Central Hospital, Zibo, China
Impact: This study suggested that MRN can evaluate
different degrees of peripheral nerve injury in GBS
patients and confirmed the correlation with
electrophysiological parameters.
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Computer Number: 114
4081. Microstructural
Evaluation of Paramagnetic Rim and Non-Rim Lesions in Multiple
Sclerosis Using SANDI and NEXI
S. Buathong, K-S Chan, H. Lee, Y. Ma, E. Krijnen, A. Bhatt,
J. Gerold, F. Chiang, E. Klawiter, H-H Lee, S. Huang
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, United States
Impact: Exploration of tissue microstructural
alterations in MS lesions(PRLs.vs.non-PRLs) with advanced
diffusion metrics such as SANDI and NEXI may help us
understand lesion characteristics better and find key
markers for prognostication and determining treatment
course.
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Computer Number: 115
4082. Neuropathological
injury severity score correlates with MRI tissue microstructure
in human post-mortem traumatic cervical spinal cord injury
N. Lesack, S. Morris, A. Yung, K. Bale, A. Bauman, P.
Kozlowski, Z. Samadi-Bahrami, C. Fournier, P. Mattu, L.
Parker, K. Dong, F. Streijger, G. W. Moore, A. Velenosi, V.
Hirsch-Reinshagen, B. Kwon, C. Laule
The University of British Columbia, Vancouver, Canada
Impact: A multi-metric diffusion MRI approach can probe
different aspects of microstructural damage in spinal cord
injury. In-vivo assessment of spinal cord injury pathology
using diffusion MRI could allow for improved clinical
decision making.
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Computer Number: 116
4083. Tractography-informed
estimation of local axonal damage in multiple sclerosis
S. Bosticardo, M. Battocchio, M. Ocampo-Pineda, A. Cagol,
P-J Lu, E. Ruberte, N. De Oliveira S. Siebenborn, X. Chen,
L. Melie-Garcia, M. Weigel, L. Kappos, J. Kuhle, A. Daducci,
C. Granziera
University of Verona, Verona, Italy
Impact: In this work, we used an innovative method to
compute myelin loss, providing insight that a standard
myelin-sensitive map couldn’t provide. These values
significantly correlate with motor disability and disease
progression, enhancing our understanding of MS pathology and
treatment effects.
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Computer Number: 117
4084. Fixel-wise
reductions of thalamic fiber integrity in new onset epilepsy and
drug-resistant temporal lobe epilepsy
L. Sainburg, K. Williams, D. Doss, K. Schilling, D. Englot,
V. Morgan
Vanderbilt University, Nashville, United States
Impact: Our results suggest that ventral thalamus fibers
may be damaged in temporal lobe epilepsy and this damage
could be detectable in early-stage epilepsy. These results
may have implications for thalamic neurostimulation and
future studies of progression in new onset epilepsy.
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Computer Number: 118
4085. Comparing
the Classification Accuracy and Spatial Distribution of
Diffusion MRI and PET in Alzheimer’s Disease
A. Ulug, R. Watts, R. Haxton
Cortechs Labs, Inc., San Diego, United States
Impact: Accurate diagnosis and monitoring disease
progression of AD patients using diffusion MRI will improve
clinical management of AD patients. Particularly, the AD
patients undergoing drug therapy and regular MRI scans will
benefit.
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Computer Number: 119
4086. The
Association of the Glymphatic Function with amyloid deposition:
a clinical stage-specific Approach
K. M. Kang, H. Nam, C. Park, M. S. Byun, D. Yi, C-H Sohn, D.
Y. Lee
Seoul National University Hospital, Seoul, Korea, Republic of
Impact: These findings suggest the ALPS index as a
potential early biomarker for Alzheimer’s, highlighting
glymphatic dysfunction’s role.
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Computer Number: 120
4087. Exploring
CSD for High-Resolution Diffusion Imaging of the Cervical Spinal
Cord Ex Vivo
I. Hattan, G. Cowin, N. Kurniawan
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland, Australia
Impact:
This study demonstrates CSD’s effectiveness in high-resolution diffusion imaging to map complex spinal cord microstructures, precisely resolving crossing fibres and axonal projections. These insights significantly enhance anatomical understanding, paving the way for improved clinical assessments of spinal cord pathways. |
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Computer Number: 121
4088. Longitudinal
changes in superficial white matter microstructure in cerebral
small vessel disease
S. Wang, M. Lin, C. liu, J. Sun
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Impact:
We revealed the longitudinal changes in the microstructure of SWM in CSVD and their impact on cognition. Results suggest the pathological mechanisms influencing the changes in the microstructure of SWM. |
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Computer Number: 122
4089. Influence
of TDP-43 on temporal lobe diffusion metrics using DTI and NODDI
in Alzheimer-related TDP-43 proteinopathy
A. Lavrova, N. T. T. Pham, R. Reid, B. Boeve, D. Knopman, R.
Petersen, A. Nguyen, R. Reichard, D. Dickson, C. Jack, J.
Whitwell, K. Josephs
Mayo Clinic, Rochester, United States
Impact: The study demonstrates that TDP-43 significantly
affects brain microstructure in AD, particularly in the left
temporal lobe, with diffusion changes from DTI and NODDI
potentially serving as biomarkers for early detection and
diagnosis of TDP-43 in AD.
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Computer Number: 123
4090. Mediation
effects of white matter abnormalities in the associations
between cerebral small vessel disease burden and cognitive
impairment
C. Sui, L. Guo, H. Wen, H. Xin, M. Feng, Y. Gao, N. Wang, X.
Zhang, y. wang
Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Impact: Combining DTI-derived diffusivity and anisotropy
metrics can provide complementary information for assessing
WM alterations associated with cognitive dysfunction, which
helps us to understand the mechanism of cognitive impairment
in CSVD-s.
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Computer Number: 124
4091. High
Resolution Diffusion Tensor Imaging of Brainstem Nuclei Across
the Healthy Lifespan
M. Soliman, N. Osadunkwu, P. Stack-Sanchez, N. Naji, P.
Seres, A. Wilman, D. Gross, R. Camicioli, C. Beaulieu
University of Alberta, Edmonton, Canada
Impact: High-resolution diffusion MRI of brainstem
nuclei indicated marked non-linear changes with age across
the typical lifespan that differed with sex. This
establishes a baseline for investigation of micro-structural
alterations of the red nucleus and substantia nigra in
neurological disorders.
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Computer Number: 125
4092. Elevated
Apparent Diffusion Coefficient of Water in Extra-axial Space
following Acute Head Injury
S. Cheng, N. Peterkin, M. Luby, L. Turtzo, L. Latour
Acute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States
Impact: Clinical diffusion imaging may be used to detect
TME and predict TME at follow-up without the need for
contrast administration, suggesting diagnostic utility for
acute TBI patients.The contribution of flow to elevated ADC
values will be further explored.
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Computer Number: 126
4093. Cardiometabolic
Impacts on Brain Microstructure: Fixel-Based Analysis and
Cognitive Prediction
H. S. Park, B. Jeong
Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of
Impact: This study aims to capture micro-structural
brain changes undetected in prior research. Fixel-based
analysis allows precise mapping of cardiometabolic factors'
effects on specific tracts and networks, enhancing
predictive accuracy for cognitive function correlations at
the individual level.
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Computer Number: 127
4094. Brain
Network Topological Properties Was Associated No Evidence of
Disease Activity Status in Relapsing-Remitting Multiple
Sclerosis Patients
Z. Yan, X. Yang, B. Lin, Q. Zhu, Z. Shi, J. Feng, Y. Li
the First Affiliated Hospital of Chognqing Medical University, Chongqing, China
Impact: Specifically altered mrTPCs were linked to
short-term NEDA status in RRMS patients on oral DMTs.
Although the specific mechanisms for achieving each NEDA
status may differ and need further investigation, these
findings can help clinicians personalize RRMS treatment and
monitoring.
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Computer Number: 128
4095. Coupling
analysis of MRI-detected impaired glymphatic system with
abnormal cerebral blood flow in methamphetamine-dependent
patients
P. Cheng, Y. Li, Q. Wen, L. Liang, W. Zhou
Department of Radiology, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China, ningbo, China
Impact: DTI-ALPS showed the potential to emerge as a
novel imaging biomarker for MA dependence. Furthermore, the
strong coupling between the ALPS and CBF might contribute to
understanding the changes of brain function in MA-dependent
patients.
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