ISMRM25 - Mesocale fMRI

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Digital Poster

Mesocale fMRI

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Mesocale fMRI

Digital Poster

fMRI

Tuesday, 13 May 2025

Exhibition Hall

08:15 - 09:15

Session Number: D-116

No CME/CE Credit

		Computer Number: 65 2325. Spatiotemporal variation of the negative hemodynamic response function along the cortical surface of the primary visual cortex in human brain View Presentation Video A. Vinogradov, N. J. Fesharaki, M. Jung, J. Kim UTHealth Houston, Houston, United States Impact: An evolution of nHRF dynamics is apparent with distance from the SR. Different types of nHRFs are found, indicating more complex dynamics of the nHRF.
		Computer Number: 66 2326. Effect of thermal and physiological denoising on laminar functional connectivity View Presentation Video M. Guidi, G. Giulietti, D. Sharoh, H. Möller, D. Norris, F. Giove INFN-LNS, Catania, Italy Impact: High-resolution BOLD-fMRI data can provide information on laminar functional connectivity (FC), but physiological and thermal noise could strongly degrade signal quality and bias results. This study quantifies the impact of different denoising strategies in the estimation of laminar FC strength.
		Computer Number: 67 2327. 7T Spin-echo functional MRI reveals mirrored representations in the human motor cortex View Presentation Video S. Han, S. Eun, D. Kim, H. Cho, S-G Kim Korea Basic Science Institute (KBSI), Ochang, Korea, Republic of Impact: By facilitating real-time assessment of individual performance and utilizing motor behavioral data, this approach will improve the quality of fMRI data analysis and may support a diverse range of experimental paradigms.
		Computer Number: 68 2328. CAIPI accelerated 3D bSSFP for laminar fMRI at 7T View Presentation Video Z. Zhang, Y. Wang, C. Liu, Q. Zhang, J. An, C. Qian, P. Zhang, Z. Zhang State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Impact: This study integrates 3D bSSFP acquisition into task-based fMRI, employing 2D-CAIPI acceleration to enhance acquisition speed, and conducts a comparative analysis with BOLD fMRI, highlighting the superior spatial localization accuracy of bSSFP.
		Computer Number: 69 2329. Combined prospective and retrospective motion correction for high-resolution linescan acquisitions in the human cerebral cortex at 7T View Presentation Video M. Balasubramanian, J. Polimeni, D. Tisdall, A. van der Kouwe, R. Frost Harvard Medical School, Boston, United States Impact: Motion-robust linescan techniques will help enable the measurement of tissue microstructure and microvascular fMRI signals at high spatial resolutions, approaching the thickness of individual cortical layers, facilitating noninvasive studies of cortical circuitry and architectonics in the living human brain.
		Computer Number: 70 2330. FMRI using 1D “linescan” and 2D imaging are also often equally sensitive: comparing SNR efficiency in theory and practice View Presentation Video N. Yusif Rodriguez, M. Cloos, M. Balasubramanian, X. Yu, J. Polimeni Massachusetts General Hospital, Charlestown, United States Impact: We address concerns that 1D linescan for BOLD-fMRI has limited SNR compared to equivalent 2D scans. Our results show comparable SNR efficiencies between these two methods, highlighting the benefits of 1D linescan for future studies of human cerebral cortical layers.
		Computer Number: 71 2331. Comparison of Layer-Specific BOLD Responses Across Cortical Depths Using 7T Line-Scanning fMRI View Presentation Video G. Liu, T. Ueguchi, S. Ogawa CiNet, NICT, Osaka, Japan Impact: The percentage change of BOLD response depends greatly on both depth from the pial surface and TE. 1D line-scanning can play a crucial role in advancing mesoscopic fMRI resolution (e.g., layer-specific fMRI), potentially surpassing the conventional resolution of 0.8 mm
		Computer Number: 72 2332. Cortical layer-dependent response changes in M1 in Parkinson's Disease: a submillimeter 7T fMRI study with 3D passband balanced SSFP View Presentation Video Y. Wang, D. Su, R. Yan, L. Knudsen, N. Wei, J. An, T. Feng, P. Zhang State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, BeiJing, China Impact: These findings provide clues to to dysfunctions and progression of PD in the M1 microcircuitry, showscasing that laminar fMRI is a valuable tool for investigating the mechanisms underlying neurodegenerative disorders.
		Computer Number: 73 2333. Should I do 7T fMRI with the pTx or sTx coil? Consider the difference in geometry View Presentation Video R. Huber, A. T. Morgan, A. Pizzuti, B. Poser, B. Dymerska, D. Bosch, Y. Chai, N. Gudino, J. Sarlls, S. Dresbach, A. T. Vu, J. Evans, S. Torrisi, R. Stirnberg, M. Tourell, S. Bollmann, L. Vizioli, E. Yacoub, N. Priovoulos, E. Brouwer, W. van der Zwaag, H. Mattern, D. Gomez, A. Blazejewska, J. Polimeni, P. Bandettini NIH, Bethesda, United States Impact: Geometrical design choices play a surprisingly large role for 7T fMRI when choosing the optimal coil.
		Computer Number: 74 2334. Investigating the Impact of Spatially Selective Signal Suppression on BOLD fMRI Reliability View Presentation Video Y. He, L. Hernandez-Garcia, D. Noll, J-F Nielsen University of Michigan, Ann Arbor, United States Impact: Outer-volume suppressed fMRI can produce reliable activation maps, and may be a promising candidate for high-resolution (e.g., layer-specific) fMRI.
		Computer Number: 75 2335. Crossing the scales: Opto-magnetic imaging can reveal cortical propagation of circuit-dominating slow wave events View Presentation Video D. Cleppien, M. Schwalm, H. Backhaus, T. Fu, F. Aedo-Jury, G. Schneider, A. Stroh Leibniz Institute for Resilience Research, Mainz, Germany Impact: This study bridges concepts and methods spanning from optical imaging of local microcircuits to optic-fiber photometry and fast fMRI to follow a defined neurophysiological event, the slow wave event, across the scales, from single cells to non-invasive cortex wide fMRI.
		Computer Number: 76 2336. Investigating Venous Interference in Population Receptive Field Estimation using High-resolution 3D-EPI at 7T View Presentation Video Y. Yang, C. Qian, H. Zhang, J. An, S. Li, R. Xue, Z. Zhang State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Impact: This study provides new insights into the role of venous interference in pRF estimation, with the potential to address longstanding challenges in understanding the venous structure of visual cortex and improving the accuracy of retinotopic mapping.
		Computer Number: 77 2337. Mesoscale functional characterization of cerebellar stripes lays the foundation for linking molecular specificity to fMRI signals View Presentation Video R. Lorenzi, S. Tartabini, A. Geminiani, C. Gandini Wheeler Kingshott, C. Casellato, E. D'Angelo, F. Palesi Università di Pavia, Pavia, Italy Impact: We introduced zebrin-specificity into the cerebellar mean-field model and mapped it onto a new cerebellar high-resolution parcellation for large-scale signal modeling. This opens the possibility to refine an observational model to retain this molecular differentiation in fMRI signal simulation.
		Computer Number: 78 2338. Functional imaging of hippocampal layers using VASO on the Next Generation (NexGen) 7T View Presentation Video S. Häkkinen, A. Beckett, E. Walker, R. Huber, D. Feinberg Helen Wills Neuroscience Institute, Berkeley, United States Impact: Hippocampal fMRI using VASO contrast allows mapping layer function with high accuracy, made possible by optimization for the NexGen 7T scanner. Spatial accuracy and venous biases are a central concern for studies developing mechanistic models for hippocampal circuits.
		Computer Number: 79 2339. Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities of clinical 7T and biophysical challenges View Presentation Video K. Ahmadi, S. Swegle, M. Rubin, A. T. Morgan, A. Bouyeure, P. Bandettini, N. Axmacher, R. Huber Ruhr University Bochum, Bochum, Germany Impact: Our preliminary results indicate that mesoscale VASO collected using conventional 7T scanners can capture functional activity changes in hippocampus, providing a groundwork for future investigations of underlying neuronal circuitry of higher-order cognitive functions and their alterations in neurodegeneration.
		Computer Number: 80 2340. Spatial heterogeneity of cerebral cortical-depth response profiles in gradient-echo BOLD fMRI: neuronal or vascular origins? View Presentation Video A. Arsenovic, J. Polimeni, A. Blazejewska Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, United States Impact: Comparison of cortical-depth profiles in visual-task and breath-hold task induced BOLD fMRI responses revealed an interplay of vascular and neuronal components, which could be exploited to develop novel data-driven approaches for vascular bias mitigation and improved neuronal specificity.

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