Digital Poster
Lifespan fMRI
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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Computer Number: 49
3548. Altered
Functional Connectivity by Brain Injury Severity in Neonates
with Hypoxic-ischemic Encephalopathy
V. Vasudev, V. Rajagopalan, J. Wisnowski
Children's Hospital Los Angeles, Los Angeles, United States
Impact: Elucidating the impact of HIE brain injury on
functional connectivity not only furthers our understanding
of HIE, but also, more broadly, how acute brain injury
disrupts activity across complex functional brain networks
leading to neurologic dysfunction.
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Computer Number: 50
3549. Cerebral
Blood Flow Assessment in Bronchopulmonary Dysplasia With or
Without Neonatal Pneumonia in Preterm Infants
N. Wang, L. Lu, K. Wang, L. Meng, J. Liao, X. Li
Department of Radiology, the Third Affiliated Hospital of Zhengzhou University, ZhengZhou, China
Impact:
This study examined changes in cerebral blood flow in preterm infants with or without neonatal pneumonia using 3D-ASL. The findings may enhance clinical management and care for vulnerable populations affected by lung and brain diseases. |
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Computer Number: 51
3550. Personalized
functional network topographic mapping in human neonates
J. Zhao, Y. Xu, Z. Cui, H. Li, L. Sun, X. Liang, M. Han, Z.
Zeng, Q. Li, T. Zhao, Y. He
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing , China
Impact: Our results highlight how neonatal brain
function architecture organizes, develops and supports the
emerge of diverse behaviors.
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Computer Number: 52
3551. Do
Infants Exhibit Adult-like Multi-scale Functional Networks?
P. Bajracharya, V. Calhoun, S. Shultz, A. Iraji
The Tri-Institutional Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University (GSU), Atlanta, United States
Impact: This study provides foundational insights into
early brain network development, aiding clinicians and
researchers in understanding infant neurodevelopment. It
opens avenues for age-related biomarkers in the early
diagnosis of developmental disorders, enhancing intervention
timing and strategies.
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Computer Number: 53
3552. Non-Linear
Trajectories of Brain Network Development in Infants: Insights
from Resting-State fMRI
M. Seraji, S. Shultz, Q. Li, A. Iraji, V. Calhoun
TReNDS Center, Atlanta, United States
Impact: This study advances understanding of infant
brain development by revealing distinct growth patterns
across networks, which can inform early detection of
atypical neurodevelopment. Future research may explore how
these trajectories correlate with cognitive and behavioral
outcomes, enhancing early intervention strategies.
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Computer Number: 54
3553. Amygdala-prefrontal
functional connectivity mediates the effects of COVID-related
prenatal stress on infant temperament
X. Li, X. Long, K. Manning, A. Jaffer, G. Giesbrecht, L.
Tomfohr-Madsen, C. Donnici, T. Oberlander, C. Lebel
University of Calgary, Calgary, Canada
Impact: Our study suggests a possible neural biomarker
for predicting early atypical infant temperament caused by
prenatal stress exposure. This helps understand the
mechanisms via which prenatal stress can impact child
development and points to potential intervention targets.
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Computer Number: 55
3554. Direct
Estimation of Pediatric Heart Rate Variability from BOLD-fMRI: A
Machine Learning Approach Using Dynamic Connectivity
A. Addeh, K. Ardila, R. J. Williams, G. B. Pike, M. E.
MacDonald
University of Calgary, Calgary, Canada
Impact: This method enhances pediatric fMRI by
eliminating the need for peripheral
photoplethysmography devices, reducing costs and simplifying
procedures. It could also improve the robustness of
pediatric fMRI studies, which are more affected by
physiological and developmental variations than in adults.
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Computer Number: 56
3555. Holistic
brain functional parcellation in young children
K. Thung, W. Lyu, K. M. Huynh, S. Ahmad, P-T Yap
UNC at Chapel Hill, Chapel Hill, United States
Impact: We present a comprehensive whole-brain
functional parcellation for infants and young children,
offering a detailed view of early brain function. This
parcellation supports studies on brain development and
advances research on disorders affecting infants and young
children.
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Computer Number: 57
3556. Childhood
maltreatment affects functional changes in neurovascular
coupling in non-suicidal self-injury behavior in adolescents
L. Li, C. He, C. Xie
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China, Nanjing, Jiangsu, China
Impact: This study demonstrated the presence of
altered NVC in NSSI adolescents. These findings provide new
neuroimaging markers for understanding the impact of CM on
the development of NSSI behaviors and for early
identification and precise intervention in NSSI adolescents.
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Computer Number: 58
3557. Altered
Functional Brain Activity and Connectivity in Children with
β-Thalassemia: A Resting-State fMRI Study
H. Zheng, M. Jiang, Y. Wang, H. Yu, W. Cui, J. Liang, H. He,
X. Yang, R. Wang, M. Bu, X. Deng
The First Affiliated Hospital of Guangxi Medical University, Nanning,Guangxi Province, China
Impact: This study reveals dysfunction in several brain
regions in children with β-TM, particularly in the frontal
pole, precuneus, and visual cortex. These findings may
enhance understanding of cognitive impairment mechanisms and
support the development of targeted interventions for β-TM.
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Computer Number: 59
3558. Altered
static and dynamic functional connectivity of visual-oculomotor
pathway in childhood basic-type intermittent exotropia
M. zhou, Q. Shi, H. Li, M. Su, H. Zhang, J. Hong, X. Wang,
X. Zhang, X. Wan, J. Fu, Z. Liu
Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Bei jing, China
Impact: Children with basic-type IXT exhibited aberrant
sFC and dFC in bilateral higher visual cortex-oculomotor
cortex pathways. These findings provide a new perspective to
understand the neuropathological mechanisms of visual
perception and oculomotor impairments associated with
basic-type IXT.
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Computer Number: 60
3559. Neural
Effect of Childhood Maltreatment on Neurovascular Coupling in
Adolescent Depression
S. Liu, C. Xie
southeast university, Nanjing, China
Impact: These results enhance our understanding of the
neural mechanisms underlying depression and suggest
neuroimaging biomarkers for CM-related vulnerability to MDD
in adolescents.
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Computer Number: 61
3560. Periventricular
White Matter Hyperintensity Prunes the Resting State
Connectivity of Default Mode Network with Aging
V. Tiwari, N. Gupta, A. Praharaj, N. Yadav
Indian Institute of Science Education and Research Berhampur, Berhampur, India
Impact: This study reveals a threshold of
periventricular white matter hyperintensity impacting
default mode network connectivity with age, highlighting WMH
load’s role in disrupting connectivity. Resting-state
network health and WMH load are essential for understanding
cognitive aging trajectories.
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Computer Number: 62
3561. Age-related
changes in intrinsic connectivity in the hippocampus
Q. Wang, Y. Zhang, X. Jia, Q. Yang
Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Impact: This study provides important insights into the
brain mechanisms underlying age-related cognitive decline,
specifically highlighting MRI-based changes in hippocampal
intrinsic connectivity. These findings also suggest
potential targets for hippocampus-targeted interventions to
mitigate cognitive decline.
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Computer Number: 63
3562. Characterizing
age-related changes in cerebellar BOLD low frequency
fluctuations
J. Korte, W. Joiner, A. Fan
Univ. of California, Davis, Davis, United States
Impact: Cerebellar (f)ALFF reveals robust differences
between young and older participants. This
semi-quantitative, functional metric has potential to
characterize healthy aging, which can be used to identify
correlations with behavior related to the cerebellar
function.
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Computer Number: 64
3563. Changes
of cortical functional complexity across the lifespan in men and
women
D. Wijesinghe, K. Lynch, L. Aksman, D. Wang, K. Jann
Keck School of Medicine at University of Southern California, Los Angeles, United States
Impact: The findings of this study help to understand
the lifespan trajectories of the complexity of regional
brain function among men and women.
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