Digital Poster
Preclinical Brain MRI/MRS Methods & Applications
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
Digital Poster
Preclinical Brain MRI/MRS Methods & Applications
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Computer Number: 145
3642. Cortical
BOLD fMRI with multi-slice EPI at the 1.5-2nL voxel size with a
14T scanner
Y. Jiang, X. Liu, X. Zhou, D. Hike, X. Yu
Massachusetts General Hospital Department of Radiology, Charlestown, United States
Impact: To resolve the vessel-specificity of fMRI with
ultra-high resolution method at the brain-wide scale would
open a new avenue to study hemodynamic and vasodynamic
responses given its direct vascular origin.
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Computer Number: 146
3643. Simultaneous
rsfMRI and EEG reveal the brain-wide actions of delta-gamma
neural oscillations coupling
J. Wen, L. Xie, Q. Lyu, Z. Zhang, E. X. Wu, A. T. L. Leong
The University of Hong Kong, Hong Kong SAR, China
Impact: We posit that the findings from this study will
provide critical insights into where and how ZI neural
activities are distributed throughout the brain, and their
contributions to brain functional connectivity.
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Computer Number: 147
3644. Dissecting
the strain and sex specific connectome signatures of
unanesthetized C57BL/6J and DBA/2J mice using MRI
T. Arefin, H. Ünsal, T. Neuberger, N. Zhang, H. Kamens
Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center, Rochester, United States
Impact: Understanding strain and sex-dependent
signatures of the brain connectome is extremely important to
consider when determining neural mechanisms that explain
complex behavioral and disease states.
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Computer Number: 148
3645. Hyperpolarized
13C MRS can detect alterations in the astrocyte-neuron lactate
shuttle (ANLS) in the healthy mouse brain
T. Vasilkovska, X. Gao, S. Malaquin, L. Mathiesen, M.
Radoul, J. Gordon, M. Chaumeil
University of California, San Francisco, San Francisco, United States
Impact: This study indicates that HP 13C
MRS can be used to investigate alterations in the
astrocyte-neuron lactate shuttle in the brain, showing the
potential in applying this method to investigate metabolic
changes in neurological disorders.
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Computer Number: 149
3646. QQ-based
oxygen extraction fraction (OEF) mapping in mouse brain: Initial
Experience
Q. Boyer, D. Lee, H. Cho, J. Cho
University at Buffalo, Buffalo, United States
Impact: These findings validate QQ’s application in
mouse models, enabling detailed investigations into cerebral
oxygen metabolism under various physiological and
pathological conditions. Preclinical QQ-based OEF will
therefore be highly beneficial for understanding disease
mechanisms and treatment effects in neurologic disorders.
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Computer Number: 150
3647. Neurodevelopmental
effects of parental high fat/high sugar diets assessed by
structural MRI in a mouse model
E. McKnight, G. Lee, K. Wilk, T. De Young, C. Chong, L. Fan,
T. Ayoub, J. Lerch, M. Palmert, B. Nieman
University of Toronto, Toronto, Canada
Impact: Parental consumption of a high fat or a high fat
and high sugar diet prior to and during pregnancy induces
neurodevelopment changes that last well into adulthood, with
possible implications for development of NDDs in humans.
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Computer Number: 151
3648. Evolution
of the motor cortex microstructure and its lateralization: a
comparative study of chimpanzees and humans
M. Chauvel, E. Kirilina, I. Lipp, C. Jäger, K. Pine, L.
Edwards, S. Ebel, K. Kopp, S. Helbling, P. McColgan, D.
Rose, T. Gräßle, D. Chaimow, C. Crockford, R. Wittig, N.
Weiskopf
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Impact: The evolution of hand motor skills involves
significant changes in cortical microstructure. Our findings
provide valuable insights into the anatomical underpinnings
of distinct motor behaviors, such as extensive tool use
observed in hominids
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Computer Number: 152
3649. Comprehensive
Analysis of Brain Connectivity and Optimal Sample Size in Common
Marmosets Under Isoflurane Anesthesia
D. Yoshimaru, T. Tsurugizawa, J. Hata, K. Muta, N. Hayashi,
T. Marusaki, S. Shibukawa, H. Okano, H. Okano
The Jikei University School of Medicine, Tokyo, Japan
Impact: This study overcame sample size limitations in
marmoset brain connectivity research by using adequate
subjects, revealing previously unknown functional networks
under anesthesia while providing insights into primate brain
similarities and establishing appropriate sample size
requirements.
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Computer Number: 153
3650. Impact
of Mild Traumatic Brain Injury on Gray Matter Development in
Adolescent Rats: Inhibition of Regional Growth
T-H Tang, Y-W Sung, P-H Kuo, Y-C Jill Kao
National Yang Ming Chiao Tung University , Taipei, Taiwan
Impact: Our study replicates developmental patterns
following pediatric mild traumatic brain injury (mTBI) and
highlights how mTBI disrupted growth patterns in the
adolescent brain. These findings suggest that clinicians
should closely monitor pediatric TBI cases for developmental
delays.
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Computer Number: 154
3651. Along-Tract
Vertex-Based Analysis of Fiber Bundles for Early Biomarker
Discovery in a Rodent Model of Post-Traumatic Epilepsy
A. Sharma, N. Harris, O. Grohn, J. Tohka, A. Pitkanen, D.
Duncan
University of Southern California, Los Angeles, United States
Impact: This work provides an enhanced tractography
approach for detecting early structural markers associated
with PTE, improving clinical predictions and intervention
timing for patients at high risk of epilepsy after TBI.
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Computer Number: 155
3652. Cerebral
change of the fractional amplitude of low frequency fluctuation
(fALFF) in a harmaline-induced tremor rat model
S-M Huang, K-H Cho, L-W Kuo
National Cheng Kung University, Tainan, Taiwan
Impact: This study shows the fALFF changes in the
cerebrum of the harmaline-induced tremor rat model,
providing the first insight into the brain activity of
cerebral area in addition to classical tremor cerebellar
circuit.
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Computer Number: 156
3653. Multi-parametric
MRI study of stroke in Model Aged Hypertensive Rats
A. Bosomtwi, A. Alshammari, B. Pillai, R. Ara, P. Kamat, S.
Fagan
Augusta University, Augusta, United States
Impact: The C21-treatement improve outcome.
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Computer Number: 157
3654. Common
coordinate framework of developmental macaque brain from birth
to early childhood based on ultra-high-resolution diffusion MRI
Z. Zhang, T. Zhu, J. Guo, M. Ouyang, A. Sousa, J.
Levine, A. Kriegstein, H. Huang
Children's Hospital of Philadelphia, Philadelphia, United States
Impact: These first age-specific developmental macaque
brain CCFs, featuring 0.2mm isotropic ultra-high-resolution
diffusion imaging, serve as neuroanatomical references. They
facilitate the mapping of genetic, cellular, and molecular
data and offer image templates, establishing foundations for
discoveries in brain development and evolution.
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Computer Number: 158
3655. Vascular
and metabolic responses to elevated circulating PDGF-BB in mice:
A multiparametric MRI study
X. Yang, J. Wang, Y. Li, M. Wan, Z. Wei
The Johns Hopkins University School of Medicine, Baltimore, United States
Impact: Excessive circulating PDGF-BB is associated with
impaired blood supply and hypermetabolism in mice, which
aligns with the major pathophysiological changes in human
aging. It provides a functional proof that excessive PDGF-BB
is a pro-aging factor and a potential therapeutic target.
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Computer Number: 159
3656. Investigating
Abnormal Glymphatic Function and Perivascular Space in
Alzheimer’s Disease Using Dynamic Contrast-Enhanced MRI and
DTI-ALPS
Y-W Liang, C-W Chang, S-J Li, T-Y Cho, T-C Chen, C-R Yang,
Y-C Lo, Y-Y Chen
National Yang Ming Chiao Tung University, Taipei, Taiwan
Impact: This study reveals the relationship between glymphatic
function and PVS in AD animal model.
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