Digital Poster
Preclinical Sequences, Hardware, Software
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
Digital Poster
Preclinical Sequences, Hardware, Software
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Computer Number: 145
3168. RF
Pre-emphasis for suppression of coil-to-coil coupling in
multiple-mouse MRI
T. DeYoung, O. Botelho, S. Wong, J. Sled, B. Nieman
University of Toronto, Toronto, Canada
Impact: Multiple-mouse MRI enables high-throughput
pre-clinical studies. Implementations at high-field may show
a greater degree of coil-to-coil coupling that reduces image
quality. We present a compensation strategy to reduce these
effects and improve image quality for high-throughput
studies.
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Computer Number: 146
3169. Wireless
array for SNR enhancement in small animal MRI at 5T
W. Liao, E. Xiao, G. Yang, P. He, W. Cao, F. Du, N. Li, L.
Chao, X. Zhang, Q. Chen, Y. Li
Chinese Academy of Sciences, Shenzhen Institute of Advanced Technology, Shenzhen, China
Impact: The experiment demonstrated the potential of
wireless RF coils for high-resolution imaging in small
animal MRI.
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Computer Number: 147
3170. Evaluation
of Physiological Characteristics of in vivo AGN Probe Using
Multimodal Imaging
N. Koyasu, H. Yatabe, Y. Takakusagi, Y. Saito, S. Sando, M.
Krishna, K. Yamamoto
National Institutes of Health, Bethesda, United States
Impact: The hyperpolarized AGN probe provides a novel,
non-invasive method for real-time monitoring of APN activity
in tumors, even in hypoxic and low-perfusion regions, thus
providing therapeutic strategies and personalized cancer
treatment
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Computer Number: 148
3171. Automated
Brain Extraction for Multi-Contrast MRI in Rat Models Using
Enhanced U-Net
L. Hakki, M. Özakçakaya, B. Tavashi, U. Pamuk, O. Hüraydın,
E. Öztürk Işık, P. Özbay
Boğaziçi University, İstanbul, Turkey
Impact: The U-Net model resulted in high segmentation
accuracy for various rat brain MRI contrasts. This approach
reduced the need for manual brain segmentation for a more
automated data processing.
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Computer Number: 149
3172. A
Multi-Parameter Mapping (MPM) protocol optimized for the mouse
brain
J. Fouquet, M. Urosevic, Y. Yee, Y. Liu, K. Moshref, D.
Gallino, G. Devenyi, M. M. Chakravarty
Douglas Research Centre, Montreal, Canada
Impact: An MPM protocol optimized for the mouse brain is
now available and characterized, enabling the study of the
cerebral microstructure in preclinical models with high
translational potential.
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Computer Number: 150
3173. End-to-end
learning of variable flip angle schemes for sharper 3D MRI of
biological samples at 11.7T
S. Mayer, M. Blaimer, M. Gram, M. Hamers, M. Zaiss, L.
Borisjuk, P. Jakob, P. Dawood
University of Würzburg, Würzburg, Germany
Impact: This work showcases the benefit of dedicated VFA
optimization for pre-clinical ultrahigh field MRI by
enabling tailored imaging protocols enhancing SNR or
sharpness. Its adaptability holds promise for fast and high
throughput imaging of biological samples and plant research
applications.
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Computer Number: 151
3174. Automatic
muscle segmentation of MRI images of mice with nnU-net
B. Matot, L. Rigler, R. Ait-Ouaret, C. Prot-Bertoye, C.
Griveau, G. Brideau, B. Marty, H. Reyngoudt, Y. Fromes, P-Y
Baudin
Institute of Myology, Paris, France
Impact: Our automatic muscle segmentation tool
significantly speeds up the processing duration of MRI data
and therefore the development of new quantitative MRI
outcomes in the field of neuromuscular disorders.
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Computer Number: 152
3175. Metabolism
of choline and deuterated choline detected by 1H-14N 2D
heteronuclear single-quantum coherence (HSQC) NMR
R. de Graaf, M. Thomas, H. De Feyter
Yale University, New Haven, United States
Impact: A single 1H-14N
2D HSQC scan can quantitatively map all forms of protonated
and deuterated choline, phosphocholine and
glycerophosphocholine, opening the possibility of
comprehensive study of dynamic 2H-choline
transport, turnover and metabolism.
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Computer Number: 153
3176. Quantifying
the young rat brain: a cross-sectional region-based analysis of
T1, T2, R2*, and quantitative susceptibility maps.
B. TAVASHI, L. Hakki, U. Pamuk, O. Hüraydın, E. Öztürk Işık,
P. Özbay
Boğaziçi University, Istanbul, Turkey
Impact: Quantitatively characterizing the brain of
Wistar rats is valuable for research about healthy and
abnormal conditions. So, to understand aging, qMRI is very
useful. Exploring the quantitative properties of brains of
young rats provides reference for comparative work.
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Computer Number: 154
3177. Evaluation
of vendor-neutral deep learning-based image reconstruction
software for preclinical mouse brain MRI
T. Oki, S. Ishida, S. Misaki, T. Iwai, G. Jeong, Y. Watanabe
Shiga University of Medical Science, Otsu, Japan
Impact: The vendor-neutral deep learning-based
reconstruction software trained only using clinical human MR
images demonstrated excellent image quality improvement in
mouse brain MR images which are preclinical images not
included in the training dataset.
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Computer Number: 155
3178. Lighting
Up Premetastatic Niche Using Magnetic Particle Spectroscopy for
Highly Sensitive Detection of Extracellular Matrix
Viscoelasticity
W. Huang, W. Li, K. Wang, J. Tian, S. Zhang
Jinan University First Affiliated Hospital, Guangzhou, China
Impact: With such a low-cost and portable COM-MPS
device, this technique has potential to provide a sensitive
and convenient method to identify rECM at the early stage of
tumor metastasis or before the formation of secondary
tumors.
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Computer Number: 156
3179. Simultaneous
MRI oximetry and electrical recording in the brain using ECoG
electrodes infused with pO2 reporter molecules
C. Seaton, L. Teixeira, Y. Sugamura, S. Amin, J. Muthuswamy,
V. Kodibagkar
Arizona State University, Tempe, United States
Impact: Researchers aiming to measure neuronal activity
would benefit from the additional quantitative pO2
measurements during rest, brain stimulations, and disease
models such as stroke.
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Computer Number: 157
3180. Off-target
Effects of DREADD Actuators Result in Attenuation of BOLD
Responses to Optogenetic Stimulation
C-H Lee, G. H. Im, S-H Choi, S-g Kim
Institute of Basic Science, Suwon, Korea, Republic of
Impact: Our findings suggest that careful consideration
for the DREADD actuator selection and control experiments
for optimal dose are needed. This will have significant
implications for chemogenetic fMRI studies.
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Computer Number: 158
3181. The
Combined Use of Dual-Tuned 1H/2H Coils and Metamaterial Coils
for Enhanced UHF Imaging Performance in Mice
P. He, E. Xiao, G. Yang, N. Li, F. Du, W. Liao, S. Gao, W.
Cao, Y. Ouyang, X. Zhang, Y. Li
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Impact: The research results indicate that introducing
the metamaterial coil enhances hydrogen-deuterium
dual-nuclear imaging. To reduce the impact of coil coupling
on imaging, further studies are needed. Future animal
experiments on mouse brains will provide insights for
research on human brain .
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Computer Number: 159
3182. 3D
Printed Ferret Cradle with Anesthesia and Commercial Coil
Integration for Brain MRI at 7T
L. Dieckhaus, A. Cruz, L. Falbinan, J. Mendoza, R. Carlson,
D. Celdran-Bonafonte, K. O’Connell, J-P Galons, E.
Hutchinson
University of Arizona, Tucson, United States
Impact: Creating custom ferret cradle that integrates
commercial-coils may benefit other researchers that are
imaging animal models.
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Computer Number: 160
3183. Preliminary
results of slow flow velocity mapping for analysing flow in
plants.
N. Knorr, J. Leupold, P. Rovedo, L. Hesse, S. Bär
University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Impact:
Validating the slow flow velocity measurements in phantoms with sub-mm dimensions allows us to confidently apply the Pulsed Field Gradient Turbo Spin-Echo technique for slow-flow measurements with unknown velocities. |
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