Digital Poster
Renal Blood Flow & Oxygenation
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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Computer Number: 1
2421. Diffusion
Kurtosis Imaging and Arterial Spin Labeling MRI for
Post-Contrast Acute Kidney Injury in Rats with Subclinical Acute
Kidney Injury
H. Yuan, S. Xie, J. Zhu, B. Kuehn, R. Grimm, W. Shen
The First Central Clinical School, Tianjin Medical University, Tianjin, China
Impact: Risk of PC-AKI in sAKI status should be
reconsidered. Multiparameter MRI is an effective tool to
detect renal injury.
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Computer Number: 2
2422. Application
of ASL and MRE to explore changes in renal perfusion and
stiffness in hypertensive patients with CKD
Y. Chen, P. Luo, W. Liu, R. Qi, Q. Chen, J. Li, Q. Liang, F.
Meng, H. Qin, B. Kuehn, B. Huang
Shenzhen Traditional Chinese Medicine Hospital (The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine), Shenzhen, China
Impact: The study confirms the correlation between renal
stiffness and perfusion in differentiating hypertensive
patients with CKD, suggesting the necessity of including the
effects of perfusion status and hypertensive state when
using stiffness values in CKD to ensure accurate assessment.
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Computer Number: 3
2423. Data-driven
Motion Correction for Paced and Free Breathing Kidney Arterial
Spin Labeling
J. Wang, J. Tamir, A. Bush
University of Texas at Austin, Austin, United States
Impact: This
study demonstrates the potential to improve poor-quality
paced-breathing kidney ASL and suggests broader
applicability to free breathing scenarios. Other dynamic
body MRI applications may also benefit from this simple
motion correction approach.
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Computer Number: 4
2424. A
Study on Predicting Individual Kidney Function Using Renal Blood
Flow Weighted eGFR Using Arterial Spin Labeling MRI
Z. Lin, Y. Li, J. Zhu, J. Qiu
Peking University First Hospital, Beijing, China
Impact: This novel method improves renal function
assessment in RAS patients, potentially guiding clinical
decisions and facilitating further research into renal
disease management.
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Computer Number: 5
2425. Analysis
of Multi-delay Arterial Spin Labeling Reveals Inaccuracies in
Kidney Blood Flow Using a Single Compartment Perfusion Model
J. Wang, A. Bush
University of Texas at Austin, Austin, United States
Impact:
This study highlights the limitations of directly applying brain kinetic models to the kidney and calls for revised models that better accommodate kidney physiology. |
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Computer Number: 6
2426. Free-breathing
quantification of renal oxygenation with field-insensitive
T2-preparation and velocity-selective EPI acquisition
Q. Xu, D. Jiang, Y. Zhang, Y-c Hsu, H. Lu, D. Wu, Z. Lin
Zhejiang University, Hangzhou, China
Impact: The
proposed method has the potential to provide accurate and
stable estimation for renal
oxygenation
quantification.
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Computer Number: 7
2427. Feasibility
of an MRI Compatible Ex-vivo Model of the Human Kidney to Assess
Flow and Perfusion
J. Rice, G. Simchick, L. Gober, D. Rice, J. Philip, D.
Hernando, A. Roldan-Alzate
University of Wisconsin - Madison, Madison, United States
Impact: MRI compatible ex-vivo models allow us to
simulate in vivo flow and perfusion in a controlled and
biologically consistent manner. Using 4D flow MRI and IVIM,
flow and perfusion can be investigated to evaluate kidney
preservation parameters and condition.
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Computer Number: 8
2428. Enhancing
clinical applicability of renal perfusion MRI: evaluation of
motion correction strategies for Arterial Spin Labeling
V. Aramendía-Vidaurreta, R. Echeverría-Chasco, M. Vidorreta,
L. García-Ruiz, P. Speier, M. A. Fernández-Seara
Clínica Universidad de Navarra, Pamplona, Spain
Impact: Pairwise registration of ASL renal perfusion
datasets shows promise for enhancing diagnostic reliability
and real-time evaluation within the MR scanner.
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Computer Number: 9
2429. Ungated,
Free-breathing MRI Quantification of Renal Metabolic Rate of
Oxygen via Conservation of Flow and Mass
N. Kamona, M. Langham, B-T Vu, R. Deshpande, F. Wehrli
University of Pennsylvania, Philadelphia, United States
Impact: Renal metabolic rate of oxygen can be a
potential biomarker for early-stage detection of diabetic
kidney disease. Non-invasive, ungated, and free-breathing
MRI-based oximetry can quantify whole-organ renal metabolic
parameters when patients cannot hold their breath for
extended periods.
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Computer Number: 10
2430. Pseudo-continuous
Arterial Spin Labeling and T1 mapping in the kidney: Effects of
field strength, sex and age
L. Garcia-Ruiz, R. Echeverría-Chasco, V.
Aramendía-Vidaurreta, J. M. Mora-Gutiérrez, N.
Garcia-Fernández, M. Vidorreta, G. Bastarrika, M. A.
Fernández-Seara
Clínica Universidad de Navarra, Pamplona (Spain), Spain
Impact: Results support the use of PCASL and T1 mapping
at 1.5T and 3T fields, widening the clinical applicability
of the techniques.
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Computer Number: 11
2431. Non-contrast
Time-SLIP Renal Perfusion Imaging using Stack-of-Stars with ASL
V. Malis, Y. Kassai, M. Miyazaki
UC San Diego, San Diego, United States
Impact: The proposed non-contrast imaging technique
provides a safe and effective alternative for renal
perfusion assessment, benefiting patients unsuitable for
gadolinium-based contrast injection studies and potentially
becoming an alternate tool for diagnosis.
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Computer Number: 12
2432. Preliminary
exploration of the value of 5T MRI arterial spin labeling and
morphological indexes in staging chronic kidney disease
T. Rong, J. Kong, W. Zeng, S. Xiang, Z. Feng
School of Medical Imaging，North Sichuan Medical College, Nanchong City, Sichuan Province, China
Impact: In conclusion, the synergistic application of
ASL and morphological assessment utilizing 5T MRI
facilitates a noninvasive, precise, and comprehensive
functional and morphological evaluation, which is pivotal
for the clinical staging of CKD.
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Computer Number: 13
2433. Evaluation
of Renal Perfusion and Oxygenation Characteristics in Patients
with Sickle Cell Disease: Preliminary Findings
D. Udayakumar, K. Olaniran, Q. Yuan, R. Toto, A.
Madhuranthakam
Mayo Clinic , Rochester, United States
Impact: Noninvasive, non-contrast ASL measured perfusion
and BOLD measured T2* and R2* provide early functional
characterization of kidneys that could facilitate
longitudinal monitoring and therapeutic interventions in
patients with sickle cell disease (SCD).
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Computer Number: 14
2434. Monitoring
treatment-induced nephropathy using multiparametric functional
MRI in patients undergoing radionuclide therapy – a pilot study
C. Liang, I. Loster, G. Aya, N. Trautwein, H. Dittmann, B.
Gückel, F. Schick, T. Küstner, C. La Fougère, P.
Martirosian, K. Nikolaou, F. Seith
University Hospital Tübingen, Tübingen, Germany
Impact: Multiparametric renal MRI could serve as an
additional non-invasive diagnostic tool to detect and
monitor radiation-induced nephropathy during cancer
treatment.
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Computer Number: 15
2435. Glomerular
Filtration Rate and Renal Plasma Flow Measurement from DCE-MRI
with Population- Arterial Input Function and a One-Compartment
Model
X. Mu, M. Liu, J. Zhang, H. Al-Mubarak, P. Kennedy, P.
Robson, J. Cuevas, B. Kuhn, K. Badani, B. Taouli, S. Lewis,
O. Bane
Icahn School of Medicine at Mount Sinai, New York, United States
Impact: Noninvasive assessment of single-kidney function
is crucial for surgical planning and guiding appropriate
treatment. The combination of pAIF and whole-kidney model
offers a promising and streamlined method for evaluating
single-kidney function by providing key parameters such as
eGFR and RPF.
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