ISMRM25 - Prostate MRI Innovations Beyond mpMRI

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Digital Poster

Prostate MRI Innovations Beyond mpMRI

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Prostate MRI Innovations Beyond mpMRI

Digital Poster

Body

Tuesday, 13 May 2025

Exhibition Hall

08:15 - 09:15

Session Number: D-59

No CME/CE Credit

		Computer Number: 17 2277. A Novel ‘Stage-Gated’ Approach for Reporting Prostate Screening MRI: “Is Less More?” View Presentation Video N. Thorley, G. Brembilla, F. Giganti, T. Barrett, T. Parry, D. Eldred-Evans, N. Mayor, A. Lamb, P. Hubbard Cristinacce, F. Gong, H. Tam, H. Sokhi, A. Padhani, C. Moore, H. Ahmed, S. Punwani University College London, London, United Kingdom Impact: A ‘stage-gated’ reporting approach for prostate MRI screening improves the positive predictive value (PPV) compared to Likert/PI-RADS scoring while maintaining comparable cancer detection rates. This approach may prove valuable in reducing unnecessary biopsies in future prostate cancer screening trials.
		Computer Number: 18 2278. Risk Stratification of prostate imaging reporting and data system (PI-RADS 3) lesions based on mean ADC values. View Presentation Video T. Kaur, Y. Jiang, N. Seiberlich, H. Hussain, S. Wells, J. Ramirez, J. Neshewat, V. Gulani University of Michigan, Ann Arbor , United States Impact: The results show that mean ADC values could help differentiate between cancers and non-cancers in PZ and TZ PI-RADS 3 lesions.
		Computer Number: 19 2279. Assessing the Feasibility of PROPELLER DWI for Prostate Imaging in Patients with Metal Implants View Presentation Video Y-C Chen, C-Y Yeh, Y-C Chen, C-W Lee, C-C Shieh, C-Y Lin, K-L Liu, Y-C Chang National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan Impact: This study indicates reduced distortion of tissues near metal implants in PROPELLER-DWI and a strong linear correlation of ADC values between PROPELLER-DWI and EPI-DWI, suggesting PROPELLER-DWI would be valuable for the diagnosis of prostate cancer in patients with metal implants.
		Computer Number: 20 2280. Prostate cancer risk assessment models for bi-parametric MRI in a large patient population View Presentation Video L. Umapathy, P. Johnson, T. Dutt, A. Tong, S. Chopra, H. Chandarana, D. Sodickson NYU Grossman School of Medicine, New York, United States Impact: Automated AI-based risk-assessment frameworks can aid personalized and objective decisions for AS. Patients with higher risks can be managed more aggressively with imaging and biopsy compared to those with lower risks, potentially avoiding overtreatment and overdiagnosis of prostate cancer.
		Computer Number: 21 2281. Factors influencing variability in interpretation of prostate MRI View Presentation Video S. J. C. Soerensen, J. Rosenberg, Z. Franks, M. Rusu, R. Fan, G. Sonn, P. Ghanouni Stanford University School of Medicine, Stanford, United States Impact: Incorporating ADC value and PSA density into PI-RADS scoring could improve diagnostic accuracy of prostate mpMRI interpretation, ultimately enhancing patient care.
		Computer Number: 22 2282. Added value of amid proton transfer weighted MRI to PI-RADS v2.1 in differentiating clinically significant prostate cancer View Presentation Video Z. Gong, Y. Ye, Y. Peng, Z. Liu, H. Ying, J. Dai, L. Gong The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China Impact: Accurately diagnosing csPCa patients is important for treatment selection. APT weighted MRI can provide significantly added value to PI-RADS v2.1 for identifying csPCa. Therefore, the application of APT weighted MRI would be beneficial for prostate cancer assessment and management.
		Computer Number: 23 2283. Comparing Performance of a New 50-Channel Pelvic Coil to that of the 30-Channel Anterior Array Coil for MRI of the Prostate View Presentation Video M. Medved, S. Huang, A. Yousuf, R. Engelmann, S. Kalidoss, A. Hamimi, C. Follante, Y. Stickle, F. Robb, A. Guidon, A. Oto, G. Lee The University of Chicago, Chicago, United States Impact: The 50-channel pelvic coil demonstrated higher image quality, SNR, and CNR and lower artifact levels in DWI/ADC and T2-weighted images, the most diagnostic sequences for prostate MRI. This can improve detection of prostate cancer and confidence of extraprostatic extension evaluation.
		Computer Number: 24 2284. Modified in-plane resolution with shorter acquisition time while maintaining high image quality T2-weighted prostate MRI View Presentation Video S. Riederer, E. Borisch, A. Froemming, R. Grimm, S. Hassanzadeh, A. Kawashima, N. Takahashi, J. Thomas Mayo Clinic, Rochester, United States Impact: Modification of the PI-RADS minimum technical standard parameters in prostate T2-weighted imaging of 0.4mm frequency × 0.7mm phase in-plane resolution to allow equivalent pixel area allows reduction in acquisition time and improved image quality.
		Computer Number: 25 2285. The Value of a Clinical-Radiomics-Deep Learning-Pathomics Fused Models for Biochemical Recurrence Prediction After Radical Prostatectomy View Presentation Video C. Hu, X. Qiao, X. Wang, J. Bao, Y. Song, J. Zhang, Z. Zhao The First Affiliated Hospital of Soochow University, Suzhou, China Impact: The multi-modality fused model incorporating clinical variable, radiomics model, MRI DL model, pathomics model was better than all single-modality models. Our model could assess the prognosis of patients with PCa after surgery, providing strong support for formulating subsequent treatment plans.
		Computer Number: 26 2286. Diagnostic value of multiparameter MRI Based on APT Imaging, Synthetic MRI, and MUSE DWI in Differentiating Benign and Malignant Prostate Lesions View Presentation Video Z. Zhao, C. Hu, J. Shi, X. Qiao, Q. Zhang, X. Wang The First Affiliated Hospital of Soochow University, Suzhou, China Impact: This study demonstrates the clinical value of using multiparametric MRI, incorporating Synthetic MRI, APT, and MUSE DWI, for improving differentiation between benign and malignant prostate diseases.
		Computer Number: 27 2287. Establishing significant correlations between multiparametric magnetic resonance histology (MRH) and cytometric features in prostate cancer S. Blocker, W. Austin, J. Cook, E. Howington, J. Huang, G. A. Johnson Duke University, Durham, United States Impact: This research provides quantitative links between magnetic resonance histology and ground-truth histopathology in prostate cancer. Not only will this improve how we implement MRH for 3D pathology applications, we will also improve our interpretation of clinical prostate MRI.
		Computer Number: 28 2288. Disease Detection Rate of Combination Ga-68 PSMA-PET/CT and Whole-Body MRI in Biochemical Recurrence After Prostatectomy View Presentation Video S. Sridhar, P. Patel, Z. Abouelfetouh, S. Chiang, R. Satkunasivam, D. Kaushik, M. Brooks, B. Miles, D. Martin, E. Efstathiou, N. Gupta Houston Methodist Research Institute, Houston, United States Impact: Our work demonstrates the added value of MRI as an addition to PET/CT scans in the context of BCR, as well as some of the limitations of PET/CT alone. Further research needs to be done in a larger patient population.
		Computer Number: 29 2289. Evaluating Synthetic DWI for Prostate Cancer Detection: Optimal TR Selection and Diagnostic Advantages over Conventional DWI View Presentation Video A. Higaki, M. Takeuchi, Y. Kojima, Y. Ueda, T. Maruhisa, Y. Fukukura, A. Yamamoto, T. Tamada Kawasaki Medical School, Okayama, Japan Impact: Optimized synthetic diffusion-weighted imaging improves prostate cancer diagnostic accuracy, enhancing lesion detection and reducing false positives compared to conventional methods. This advancement may minimize unnecessary biopsies and serve as a reliable tool in prostate cancer management.
		Computer Number: 30 2290. 18F-DCFPyL PSMA PET/MRI improves detection of clinically significant prostate cancer in men on active surveillance: Results from a Phase II trial View Presentation Video S. Wells, E. Lawrence, M. Bigarella, J. Eickhoff, D. Jarrard, S. Cho University of Michigan, Ann Arbor, United States Impact: Imaging and clinical predictive models that include PSMA PET/MRI may identify low and intermediate-risk men who could potentially avoid prostate biopsy and coincident morbidity, as well as increase the detection rates of csPC missed by MRI-biopsy alone.
		Computer Number: 31 2291. Age Dependency of Diffusion-Relaxation Coupling in the Prostate View Presentation Video A. Yen, E. Bhuiyan, Q. Luo, K. Sun, G. Dan, X. Zhou University of Illinois Chicago, Chicago, United States Impact: This study demonstrates the feasibility of using multi-readout DWI sequences to enable time-efficient investigation of age dependency of LWI parameters, providing valuable information for using LWI to evaluate prostate lesions.
		Computer Number: 32 2292. Urinary bladder as an in vivo reference for quality assurance of apparent diffusion coefficient for prostate MRI View Presentation Video L. Lawrence, R. Chan, M. Al Sharji, R. Bhayana, A. Lau, M. Haider University of Toronto, Toronto, Canada Impact: The urinary bladder serves as a reference sample for ADC, which will be necessary for quality assurance of ADC in prostate cancer diagnosis. Whether prostate ADC normalization by bladder ADC reduces interpatient variability can be investigated.

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