Digital Poster
Metabolic Body Imaging: Proton & Beyond
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
Digital Poster
Metabolic Body Imaging: Proton & Beyond
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Computer Number: 65
1722. Amide
Proton Transfer-weighted MRI in Predicting Histologic Grade of
Clear Cell Renal Cell Carcinom
Y. Xu, Q. wan, P. WU, A. Shen, p. Wang
Tongji Hospital of Tongji University, Shanghai, China
Impact: APTwmean, APTwmax, APTwSD, and ADCmin values are
potential indicators for preoperative prediction of ccRCC
pathological grading. APTwSD showed greater diagnostic
performance.
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Computer Number: 66
1723. Enhancing
the Diagnostic Performance of Prostate Cancer with PSA in the
Range of 4–10 ng/mL Using Amide Proton Transfer Texture Features
Y. Wang, Z. Shen, B. Yu, Y. Hou
Shengjing Hospital of China Medical University, Shenyang, China
Impact: MTRasym (3.5 ppm) and APTw textural features
might improve the mpMRI screening diagnostic performance of
PCa, which could reduce unnecessary biopsies.
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Computer Number: 67
1724. Multimodal
Metabolic Imaging of Resistance to Antiandrogens in Prostate
Cancer Patient-Derived Xenografts
J. Enriquez, P. Dutta, M. Wang, P. Shepherd, A. Morales, J.
Zickus, O. Otlu, J. Han, E. Labanca, D. Frigo, F.
Pisaneschi, P. Bhattacharya
UT MD Anderson Cancer Center, Houston, United States
Impact: The research described has the potential to lead
practice-changing recommendations by detecting therapeutic
efficacy earlier and changing the patient to a different
therapeutic regiment. This research also has the potential
to recommend combination therapy in the clinic to resistant
patients.
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Computer Number: 68
1725. Establishing
a Renal Biomarker Portfolio to Determine Transplant Outcomes:
Phosphorous-31 Magnetic Resonance Spectroscopy
N. Ooms, B. Bozymski, T. Hamelink, U. Dydak
Purdue University, West Lafayette, United States
Impact: Data collected here, combined with a multitude
of quantitative MRI data collected during normothermic
perfusion, will provide objective data of kidney health in
an isolated metabolic state. These data will guide surgeons
on transplant decisions.
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Computer Number: 69
1726. Feasibility
of pTx 1H MRI and single transmit 31P MRSI of the prostate at 7T
Q. van Houtum, O. Kraff, M. May, H. Quick, T. Scheenen
University Hospital Essen, Essen, Germany
Impact: 31P-MRSI
of the prostate as a possible aid in prostate cancer
characterization becomes within reach without the use of an
endorectal coil.
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Computer Number: 70
1727. Hyperpolarized
13C MRI as a New Tool to Detect Early Treatment Response and
Metabolic Heterogeneity in Advanced Renal Cell Carcinoma
H-Y Chen, R. Bok, M. Ohliger, J. Gordon, I. de Kouchkovsky,
D. Vigneron, P. Larson, A. Desai, Z. Wang
University of Califonia, San Francisco, San Francisco, United States
Impact: Management of advanced/metastatic RCC in the
salvage setting is challenging and options are limited. Our
initial positive findings highlight how HP 13C
MRI’s unique sensitivity to early treatment
response/resistance may be leveraged to improve outcomes and
avoid toxic, ineffective therapies.
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Computer Number: 71
1728. Towards
Clearer Renal 3D-APTw Imaging: Evaluating the Influence of
Breathing Techniques and Acquisition Orientations
Y. Wang, X. Wang, G. Tian, C. Yu, X. Liu, S. Zhang, H. Nie,
X. Yue, Y. Han
Xi'an Gaoxin Hospital, xi'an, China
Impact: Respiratory motion has a significant effect on
renal 3D-APTw imaging quality. Implementing efficient
respiratory compensation techniques is crucial for advancing
the accuracy and applicability of renal 3D-APTw imaging.
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Computer Number: 72
1729. Amide
Proton Transfer and Intravoxel Incoherent Motion Imaging for
Risk stratification of PI-RADS 3 Lesions in the Prostate
Transitional Zone
Y. Yun, Z. Shen, B. Jiang, L. Wang, D. Shan, C. Xu, X. Chen
The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China
Impact: PSAD, APT, and IVIM can distinguish clinically
significant prostate cancer from non-clinically significant
prostate cancer and benign prostatic hyperplasia in PI-RADS
3 lesions of the transitional zone, thereby reducing
unnecessary biopsies.
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Computer Number: 73
1730. Hyperpolarized
[13C]bicarbonate is a noninvasive metabolic biomarker of fatty
liver in humans
J. M. Park, S-H Lin, J. Baxter, C. Harrison, J. Leary, C.
Mozingo, J. Liticker, C. Malloy, E. Jin
The University of Texas Southwestern Medical Center, Dallas, United States
Impact: Noninvasive
assessment of PC and PDH pathways is important for
identifying the role of mitochondrial metabolism in hepatic
steatosis. The demonstrated method provides metabolic
insights into fatty liver and is applicable for
investigating other liver diseases with impaired
mitochondrial function.
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Computer Number: 74
1731. Rapid
Monitoring of Glycogen Dynamics: MRS-based T1 and T2 Water
Relaxation Times as potential surrogates for 13C-MRS
F. Haans, J. Mevenkamp, K. Brouwers, V.
Schrauwen-Hinderling, M. Buitinga
Maastricht University Medical Center, Maastricht, Netherlands
Impact: We demonstrate that water T1 relaxation
time measured by 1H-MRS
could provide a faster, accessible alternative to 13C-MRS
for glycogen detection, enabling real-time, simultaneous
measurement of glycogen dynamics across multiple organs.
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Computer Number: 75
1732. Quantification
of Apparent Tissue Sodium Concentration (aTSC) in the Healthy
Liver via 23Na and 1H MRI at 7T
J. Losch, A. Scheipers, J. Grimm, A. Nagel, S. Orzada, S.
Schmitter, M. Ladd, T. Platt
German Cancer Research Center, Heidelberg, Germany
Impact: This study provides essential reference data
for 23Na
MRI in healthy livers and also highlights the need to
investigate correlations between aTSC, B1- correction,
food intake, and calibration methods in healthy livers.
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Computer Number: 76
1733. NMR
and multi-omics reveal characteristic metabolome atlas and
optimize esophageal squamous cell carcinoma early detection
Y. Zhao, R. Cai, L. Ke, Z. Li, E. Wang, Y. Lin
Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China , Shantou, China
Impact: The combined model of biofluid metabolite
biomarkers based on NMR exhibits high diagnostic accuracy
and plays a crucial role in early detection of ESCC,
facilitating precise screening for high-risk populations.
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Computer Number: 77
1734. Characterizing
metabolic alterations in early stages of chronic kidney disease
(CKD): A Pathway for improved diagnosis and treatment
N. Sinha, U. Gupta, A. Sahu, D. Bhadauria, B. Baishya
Centre of Biomedical Research, Lucknow, India
Impact: The regular monitoring of these biomarkers aids
in tracking the disease's progression and developing
customized treatment plans. Furthermore, the findings guide
future research into new therapeutic targets and encourage
the application of metabolomic analysis in clinical
environments.
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Computer Number: 78
1735. Preliminary
results from Improved Prediction in Ovarian Cancer Surgery
[IMPROCAS]: a Hyperpolarized 13C Clinical Trial
M. Aastrup, U. Kjærgaard, E. Søvnsø Szocska Hansen, N.
Christensen, L. Bertelsen, F. Gallagher, S. Ringgaard, K.
Fuglsang, K. Bouchelouche, O. Mogensen, C. Laustsen, J.
Miller
The MR Research Centre, Aarhus N, Denmark
Impact: This is the first presentation of a direct
FDG/Hyperpolarized 13C
pyruvate comparison of histopathologically benign and malign
ovarian masses and highlights the metabolic distinction of
the techniques and their synergistic utility. This is of
broad interest in oncology.
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Computer Number: 79
1736. Regional
Quantification of Metabolic Liver Function Using Hyperpolarized
[1-13C] Pyruvate MRI
U. Kjærgaard, A. Lund, M. Redda, M. Kristensen, M. Aastrup,
N. Bøgh, K. Sivesgaard, M. Ohliger, D. Vigneron, L.
Bertelsen, A. Olsen Alstrup, E. Hansen, F. Mortensen, C.
Laustsen
Aarhus University, Aarhus N, Denmark
Impact: Hyperpolarized MRI can quantify regional
metabolic liver function and may be utilized to assess liver
function preoperatively to predict patients in risk of PHLF.
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