ISMRM25 - Current Advancements in Contrast Agents

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Current Advancements in Contrast Agents

Digital Poster

Contrast Mechanisms

Wednesday, 14 May 2025

Exhibition Hall

15:45 - 16:45

Session Number: D-88

No CME/CE Credit

		Computer Number: 49 3861. Transition metal based phosphonated macrocyclics for pH biosensing View Presentation Video S. K. Mishra, S. Kurdi, D. Coman, F. Hyder Yale University, New Haven, United States Impact: The Co(II)L^x- exhibited highest pH sensitivity among all reported biosensors. These biocompatible pH sensors are under evaluation for in vivo pH mapping, aiming to enable early cancer diagnosis and holding strong potential for clinical translation.
		Computer Number: 50 3862. CEST MRI detection of Glycoengineered Extracellular Vesicles View Presentation Video S. Aafreen, K. Dammen-Brower, W. Wang, S. Li, X. Han, T-H Wang, K. Yarema, G. Liu Johns Hopkins University School of Medicine, Baltimore, United States Impact: Leveraging non-natural sugars as CEST MRI agents equips MGE-EVs with advanced MRI tracking capabilities. This innovation is poised to accelerate both preclinical development and clinical translation of more effective MGE-EV-based drug delivery vectors for a wide variety of diseases.
		Computer Number: 51 3863. Multi-modal MRI for tumor diagnosis enabled by unfunctionalized 3 nm ultra-small manganese ferrite nanoparticles (UMFNPs) View Presentation Video S. Yang, W. Deng, D. Gao, Y. Zheng, W. Cui, D. Luo, Z. Sheng, Z. Liu National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Impact: Multi-modal tumor imaging with a single administration provides more comprehensive information and will enhance the accuracy and reliability of tumor diagnosis. This research highlights the potential of 3 nm UMFNPs as a versatile and powerful tool for MRI-based cancer diagnostics.
		Computer Number: 52 3864. Magnetic Resonance Imaging (MRI) to visualise tablet disintegration and dissolution in the fed stomach View Presentation Video T. Akbar, L. Marciani, P. Gershkovich, S. Stolnik-Trenkic, J. Butler, K. Stamatopoulos, P. Gowland University of Nottingham, Nottingham, United Kingdom Impact: MRI can provide insight into tablet disintegration and dissolution in the fed stomach. This has the potential to benefit drug development, by improving correlation between in vitro measurements and in vivo and informing in-silico modelling.
		Computer Number: 3865. WITHDRAWN
		Computer Number: 53 3866. Receptor-Mediated Labeling of CD4 T cells for Longitudinal Tracking of Distribution Following Systemic Injection in Mouse View Presentation Video Y. Ping, S. Han, B. Howerton, R. Adatorwovor, F. Chapelin UCSD, San Diego, United States Impact: The CD4-targeted microbead approach to track CD4+ T cells in vivo with MRI is safe, specific and sensitive. This technique will allow rapid assessment of the efficacy of adoptive cell therapies in conditions such as transplantation and diabetes.
		Computer Number: 54 3867. Using Yb-EDTA as Shift reagent for α-hydroxyl acid detection by CEST NMR View Presentation Video Z. Fang, X. Zhou, Q. Xu, S. Li, L. Zhang, S. Chen Hainan University, Sanya, China Impact: The commercially available shift agent Yb-EDTA was used to detect α-hydroxy acid via the CEST method, with the signal shifted down to around 50 ppm. This demonstrates the potential for in vivo detection without interference from magnetization transfer (MT) effects.
		Computer Number: 55 3868. Extending the utility of the hypoxia-targeting contrast agent GdDO3NI for perfusion imaging at 3T. View Presentation Video L. Damodaran, M. Duraiyarasu, S. Mantri, C. C. Quarles, V. Kodibagkar Arizona state university, Tempe, United States Impact: This preclinical study may enable a single MRI session that simultaneously informs on tumor perfusion and hypoxia, obviate the need for PET scans for hypoxia imaging and allow for improving therapeutic strategies tailored to the hypoxic state of tumors.
		Computer Number: 56 3869. Manganese-Based Single-Atom Contrast Agents with High Magnetic Resonance Imaging T1-weighted Enhancement for Tumor View Presentation Video D. Yang, Q. Li, J. Liang, H. Zhu, X. Li, Y. Xiao, C-S Lee, Y. Sun Peking University Cancer Hospital & Institute, Beijing, China Impact: The first attempt to apply manganese-single-atom in MEMRI improves that the paramagnetic metal-single-atom is the novel and ideal candidate for MRI contrast agents with charming high performance, which expand its biomedical application beyond approved therapeutic functions.
		Computer Number: 57 3870. A nomogram based on clinical factors and gadobenate dimeglumine‑enhanced MRI for prediction of GPC‑3 expression in hepatocellular carcinoma M. hui, X. yuchen, L. jiayi, W. di, L. yueming Department of Radiology, First Affiliated Hospital of Fujian Medical University, , Fuzhou, China Impact: Early noninvasive prediction of GPC-3 expression provides guidance for prognosis assessment and tumor treatment. A nomogram based on clinical and gadobenate dimeglumine-enhanced MRI can effectively predict GPC-3 expression in HCC,helping clinicians evaluate prognosis and select appropriate treatments for HCC patients.
		Computer Number: 58 3871. Development of a new class of diamagnetic pH-responsive CEST MRI contrast agents View Presentation Video P. Patkulkar, S. Panda, S. Noble, S. Jain, A. Sekhar, S. Sinharay Indian Institute of Science , Bengaluru, India Impact: We have incorporated a pH-unresponsive and a pH-responsive functional group in a small organic molecule to generate a ratiometric, concentration independent approach of extracellular pH assessment with CEST methods without any metal addition to be used for imaging bacterial infections.
		Computer Number: 59 3872. The application value of MRI multi-parameters in the differential diagnosis of solid Solitary Pulmonary Nodule L. Xiaocui, K. Xuefeng, X. Liming Huazhong University of Science and Technology, Wuhan, China Impact: Via comparing various MRI sequences with associated parameters, it was substantiated that the T2WI, DWI, and DCE could be applied to diagnose benign and malignant pulmonary nodules, laying the foundation for further MRI research and applications in lung cancer.
		Computer Number: 60 3873. 68Ga-NaGdF4-RGD nanoprobes for PET/MR Dual-Modal Imaging of cancer in Vivo s. wu, w. li, q. yang, z. chen, y. zou, y. hou, l. kang China-Japan Friendship Hospital, beijing, China Impact: This study successfully achieved simultaneous PET/MR multimodal imaging, which significantly improves the diagnostic accuracy of tumour. The radioactivity uptake of can reflect the integrin α_vβ₃ expression level of the tumour, and PET/MR is expected to be used for tumour staging.
		Computer Number: 61 3874. First demonstration of biocatalytic production of MRI contrast agent A. Al-Hilfi, A. Gilad Michigan State University, East Lansing , United States Impact: Simplifying the production of imaging probes will significantly advance and redirect our understanding of biological mechanisms, diagnosis, and treatment of human diseases. Once established, this new approach could be used to produce many novel imaging probes for specific medical conditions.

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