ISMRM25 - New Insights on Relaxation Mechanisms

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

New Insights on Relaxation Mechanisms

Digital Poster

Contrast Mechanisms

Thursday, 15 May 2025

Exhibition Hall

13:15 - 14:15

Session Number: D-89

No CME/CE Credit

		Computer Number: 33 4459. T1rho Relaxation Time as a Quantitative MRI Biomarker for Fibrosis Severity in Radiation-Induced Liver Disease: An Experimental Study in Rats Y. Wang, Y. Jiang, J. Wen, Y. Zhang, Y. Wang, F. Zhao The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Impact: T1rho MRI shows potential as a non-invasive method for detecting and monitoring liver fibrosis, enhancing early RILD diagnosis and guiding radiotherapy adjustments if validated in human studies.
		Computer Number: 34 4460. Field dependence of T2 relaxation due to diffusion through an inhomogeneous medium. View Presentation Video P. van Gelderen, J. de Zwart, Y. Wang, J. Duyn National Institutes of Health, Bethesda , United States Impact: This study helps to explain a previously observed linear dependence of R₂relaxation on the field strength (ISMRM2023:4342) by simulating the effects of diffusion through the iron-induced field inhomogeneities.
		Computer Number: 35 4461. Cartesian MPnRAGE for Efficient Simultaneous Multi-Contrast and Quantitative Relaxometry Imaging View Presentation Video C. Allen, K. Johnson, A. Alexander, S. Kecskemeti University of Wisconsin-Madison, Madison, United States Impact: Cartesian MPnRAGE provides an accurate way for efficient qT1 mapping to facilitate applications in research or clinical scanning sessions with limited scan time.
		Computer Number: 36 4462. Diagnosis of Fibrosis with Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) T1Mapping in Renal Allografts View Presentation Video O. Bane, L. Feng, D. Xia, M. Liu, I. Bolger, S. Calle, J. Dyke, M. Menon, S. Seshan, S. Salvatore, I. Stillman, T. Muthukumar, S. Farouk, B. Taouli, S. Lewis Icahn School of Medicine at Mount Sinai, New York, United States Impact: Renal T1 showed diagnostic sensitivity to the presence of renal allograft fibrosis, even in patients with preserved renal function, and thus can potentially be useful to select patients for biopsy or other interventions before serum eGFR decline.
		Computer Number: 37 4463. Visualization and Quantification of the Atrioventricular Conduction Axis Structure Using Rotating Frame Relaxation Maps in the Swine Heart View Presentation Video Y. Li, V. Casula, T. Liimatainen University of Oulu, Oulu, Finland Impact: AVCA structure can be visualized using RAFF2 and T1ρ relaxation time maps without contrast agents.
		Computer Number: 38 4464. Investigating the sensitivity of NIPAM gel dosimetry in CyberKnife systems using MRI-based R2 mapping. View Presentation Video S-L Peng, Y-H Lin, F-Y Su, H-Y Chen, W-Y Chen, C-H Yao China Medical University, Taichung, Taiwan Impact: The findings suggest potential applications of NIPAM gel dosimetry in verifying dose delivery across various stereotactic treatments.
		Computer Number: 39 4465. Investigations of T2 anisotropy in ex vivo WM using direct sample reorientation View Presentation Video A. Pampel, N. Wallstein, C. Jäger, R. Müller, H. Möller Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany Impact: This study shows that T₂ anisotropy observed under optimized ex vivo conditions cannot be described by the current models used in the MRI community.
		Computer Number: 40 4466. Development of a Double Echo-Shifted QUTE for quantification of T2* relaxation time at Ultra-High Field MRI. View Presentation Video S. Shin, A-M Oros-Peusquens, S. D. Yun, N. J. Shah Forschungszentrum Jülich, Jülich, Germany Impact: The proposed sequence offers an opportunity to sample different ranges of TE images and quantify both T₂^* and D information without a significant increase in scan time. This method is expected to make significant contributions to the study of neurofluids.
		Computer Number: 41 4467. Water Relaxation Atlas for Age- and Region-Specific Metabolite Correction in the Osprey MRS Analysis Workflow View Presentation Video G. Simegn, Y. Song, S. Murali-Manohar, H. Zöllner, C. Davies-Jenkins, K. Hupfeld, D. Simicic, A. Gudmundson, E. Muska, S. Hui, E. Carter, G. Oeltzschner, D. Dean III, C. Ceritoglu, T. Ratnanather, E. Porges, R. Edden The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States Impact: Integrating the age- and region-specific water relaxometry atlas into Osprey improves MRS metabolite quantification, particularly in aging studies, by reducing biases in water-referenced corrections.
		Computer Number: 42 4468. Comparing the test-retest reproducibility of quantitative T1 and T2 mapping: DESPOT and 3D-QALAS View Presentation Video G. Simegn, B. Gagoski, Y. Song, D. Dean III, K. Hupfeld, S. Murali-Manohar, C. Davies-Jenkins, D. Simicic, J. Wisnowski, V. Yedavalli, A. T. Gudmundson, H. Zöllner, G. Oeltzschner, R. Edden Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States Impact: Establishing the reproducibility and accuracy of T₁ and T₂ mapping is crucial for their adoption in clinical practice and longitudinal studies, particularly for ‘hybrid’ methods, like DESPOT and QALAS, that map T₁ and T₂ from a set of mixed-contrast images.
		Computer Number: 43 4469. Motion-informed free-breathing myocardial 3D T1rho mapping at 0.6T View Presentation Video V. Vousten, V. Vishnevskiy, M. Fuetterer, J. Smink, E. Ercan, S. Kozerke University and ETH Zurich, Zurich, Switzerland Impact: MI-HOSVD reconstruction efficiently and effectively uses data from all breathing states, thereby improving free-breathing 3D T1rho mapping at 0.6T.
		Computer Number: 44 4470. Repeatability and reproducibility of metabolite T2 estimates assessed with 1D and 2D models View Presentation Video C. Davies-Jenkins, D. Simicic, S. Alcicek, S. Murali-Manohar, Y. Song, R. Edden, H. Zöllner, G. Oeltzschner Johns Hopkins Medicine, Baltimore, United States Impact: This study of metabolite T₂ reproducibility is the first of its kind and suggests metabolite T₂ estimates are highly reproducible. Our early implementation of the 2D multi-TE model proved promising with scope for further development.
		Computer Number: 45 4471. Influence of spin-locking direction on T1rho quantification: evaluation in phantoms with and without T1rho dispersion property View Presentation Video J. Kim, Z. Zhang, Q. Peng, X. Li Cleveland Clinic, Cleveland, United States Impact: A newly documented phenomenon on the T1rho preparation on different B0 inhomogeneity with magnetization locked to the effective B1 presents a new question on how to handle T1rho imaging with added inhomogeneity.
		Computer Number: 46 4472. Evaluating fast R2-mapping approaches for application in temporal lobe epilepsy: a traveling head study View Presentation Video L. Mordhorst, F. Fritz, N. Lüthi, D. Wang, R. Stirnberg, D. Leitão, P. Bridgen, Z. Ning, J. Finsterbusch, S. Malik, D. Carmichael, T. Stöcker, S. Mohammadi University of Luebeck, Luebeck, Germany Impact: We identify a fast R₂ mapping method with reliable sensitivity to key regions in drug-resistant temporal lobe epilepsy. Our findings could expand R2 mapping accessibility for clinical application and contribute to improved surgical planning.
		Computer Number: 47 4473. Transverse relaxation of metabolites from birth across the lifespan View Presentation Video Y. Song, A. Gad, C. Davies-Jenkins, S. Murali-Manohar, H. Zöllner, C. Navarro, M. B. Nebel, G. Simegn, V. Yedavalli, G. Oeltzschner, R. Edden Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States Impact: Current practice in MRS quantification is to ignore well-known effects of brain-region and subject age on relaxation times. Location-specific and age-resolved T₂ reference values are a pre-requisite for accurate quantification of metabolite concentrations with MRS.
		Computer Number: 48 4474. Elucidating Water Dynamics Driving T1 Relaxation in Biological Filamentous Structures below 200mT View Presentation Video M. Rhodes, N. Mutch, L. M. Broche University of Aberdeen, Aberdeen, United Kingdom Impact: Characterising biological information inferred by FFC-NMR relaxometry will simplify non-invasive exploration into how pathology influences molecular behaviour and provides insight into new applications.

Similar Session(s)