ISMRM25 - Peak to Peak: MR Spectroscopy

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Digital Poster

Peak to Peak: MR Spectroscopy

Back to Meeting Home Back to the Program-at-a-Glance

Peak to Peak: MR Spectroscopy

Digital Poster

Contrast Mechanisms

Tuesday, 13 May 2025

Exhibition Hall

15:45 - 16:45

Session Number: D-91

No CME/CE Credit

		Computer Number: 65 2930. Retrospective lipid removal in preclinical 1H-FID MRSI at ultra-high field and potential effects on metabolite concentration estimates View Presentation Video T. T. Phan, B. Alves, T. P. Lê, A. Klauser, B. Lanz, C. Cudalbu CIBM Center for Biomedical Imaging, Lausanne, Switzerland Impact: Our work is evaluating the retrospective lipid suppression on metabolite estimates at 14.1T in the rat brain for ¹H-FID-MRSI. When using low lipid contaminated data, an effect on concentration estimates was observed, highlighting the need for future investigations.
		Computer Number: 66 2931. Phosphocreatine recovery kinetics as a biomarker to assess therapies targeting mitochondrial function View Presentation Video M. Sammi, J. Purnell, C. Butler, E. Baetscher, K. Powers, J. Mock, S. Ghosh, A. Kalmes, W. Rooney Oregon Health & Science University, Portland, United States Impact: The acute effect on mitochondrial function by RNS60 requires further studies to investigate possible mechanisms of action. k_PCr, a non-invasive and quantitative measure, can be applied as a biomarker in other therapies targeting mitochondrial function.
		Computer Number: 67 2932. Brain Atlas of Macromolecular Spectroscopic Signals from Ultrashort-TE MRSI View Presentation Video Y. Zhao, Y. Li, W. Jin, R. Guo, Y. Li, J. Luo, Z-P Liang University of Illinois at Urbana-Champaign, Champaign, United States Impact: The proposed method may lead to more accurate modelling of macromolecule signals, thus improving the quantification of metabolites in short-TE MRSI.
		Computer Number: 68 2933. Improving Temporal Resolution in fMRS: Assessing Reduced Phase Cycling in semi-LASER MRS View Presentation Video A. Ensworth, J. Kramer, E. MacMillan, C. Laule The University of British Columbia, Vancouver, Canada Impact: This study demonstrates the impact of reducing phase cycles in MRS and provides guidance on how to reduce phase cycles to enhance temporal resolution and improve the feasibility of fMRS in clinical and research settings.
		Computer Number: 69 2934. A Digital Phantom for 3D MR Spectroscopy Data Simulation View Presentation Video D. van de Sande, A. Gudmundson, C. Davies-Jenkins, D. Simicic, G. Simegn, I. Özdemir, S. Amirrajab, J. Merkofer, H. Zöllner, G. Oeltzschner, R. Edden Eindhoven University of Technology, Eindhoven, Netherlands Impact: This MRS phantom framework provides a flexible, tissue-specific model for realistic MRS and MRSI dataset simulation. Its modular design allows for precise control over the parameters and the simulation process to support a wide range of research and development applications.
		Computer Number: 70 2935. Repeatability of 13C-MRS for absolute glycogen content quantification in the human liver and skeletal muscle at 7T View Presentation Video P. Veeraiah, C. Fuchs, R. Voncken, K. Brouwers, J. Hurk, J. Wildberger, P. Thelwall, J. Prompers, L. Loon Scannexus (Ultra-High Field MRI Center), Maastricht, Netherlands Impact: ¹³C-MRS at 7T showed good repeatability for absolute glycogen quantification in human liver and muscle, which is promising for its clinical applicability to measure intervention/disease related changes in glycogen content.
		Computer Number: 71 2936. Phosphorylated metabolite T1 relaxation times measured in the macaque brain using 31P MRS at 11.7T View Presentation Video A. Lopez Kolkovsky, M. Gay, M. Roustan, T. Lilin Froment, A. Amadon, F. Mauconduit, F. Boumezbeur CEA, Gif-sur-Yvette, France Impact: Knowledge of the T₁ relaxation times will play a key role in ³¹P metabolite quantification and in determining the optimal acquisition parameters for ³¹P MRSI measurements in the macaque brain at 11.7T.
		Computer Number: 72 2937. The Differences in Macromolecular Binding Between Sodium and Potassium Ions Y. Chen, Y. Yin, J. Xia, H. Li, X. Kong Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China Impact: The analysis of ion interactions with macromolecules may help explain the distinct functions of sodium and potassium ions in biological systems.
		Computer Number: 73 2938. First implementation of fast 1H 3D-FID-MRSI on the rodent brain at 9.4T for metabolite mapping View Presentation Video B. Alves, T. Lê, B. Strasser, W. Bogner, B. Lanz, C. Cudalbu Centre d'Imagerie Biomedical - CIBM, Lausanne, Switzerland Impact: 3D and multislice ¹H-FID-MRSI can offer greater insight in the rat brain metabolism, enabling finer description of neurodegenerative diseases within preclinical models, such as the bile duct ligation rat model for hepatic encephalopathy.
		Computer Number: 74 2939. Investigation of exercise-induced skeletal muscle energy metabolism in patients with cirrhosis using dynamic 31P-MRS on a clinical MRI system View Presentation Video J. Kwon, K. Ozaki, Y. Katsumata, S. Funayama, S. Ichikawa, M. Cauteren, S. Goshima Philips Japan, Tokyo, Japan Impact: Metabolic parameters derived from dynamic ³¹P−MRS in clinical setting showed a different trend in patients with cirrhosis compared to those of healthy volunteers. It may be possible to early identify cirrhotic patients at risk of developing sarcopenia.
		Computer Number: 75 2940. A dual density rosette trajectory for rapid MRSI of the brain with a simultaneously acquired high-resolution anatomical reference View Presentation Video E. Kadalie, L. Burki, K. Hara-Lee, J. Near Sunnybrook Research Institute, Toronto, Canada Impact: A novel acquisition method was developed to simultaneously collect MRSI data and high-resolution spatial priors to suppress spectral lipid contamination. This technique thus has the potential to become a robust clinical tool for studying metabolic changes in the brain.
		Computer Number: 76 2941. Denoising MRSI Data Using Atlas-Based Statistical Subspaces View Presentation Video W. Jin, Y. Zhao, Y. Li, R. Guo, Y. Zhang, Z. Xu, J. Luo, Y. Li, Z-P Liang Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, United States Impact: This proposed method significantly improved the sensitivity of brain MRSI using atlas-based statistical subspaces. The method may further enhance the reliability and practical utility of high-resolution MRSI techniques.
		Computer Number: 77 2942. MRS fingerprinting combined with multi-dimensional linear-combination modeling for fast and accurate multi-metabolite relaxometry. View Presentation Video H. Zöllner, C. Davies-Jenkins, D. Simicic, J. Stabinska, G. Oeltzschner, R. Edden, P. Barker The Johns Hopkins University School of Medicine, Baltimore, United States Impact: MRSF combined with linear-combinaiton modeling enables accurate cohort-mean relaxation time estimation for five metabolites suitable for quantification in large studies, while conventional MRSF (using simple peak integration) may better detect small subject-specific changes in singlet relaxation times.
		Computer Number: 78 2943. Probabilistic Atlas-Based Image Reconstruction for Ultrafast MR Spectroscopic Imaging View Presentation Video Y. Li, Y. Zhao, W. Jin, R. Guo, S. Luo, Y. Li, V. Kindratenko, M. Anastasio, B. Sutton, Z-P Liang University of Illinois at Urbana-Champaign, Urbana, United States Impact: With the capability to reduce imaging dimensionality and improve SNR, the proposed method can further accelerate MRSI scans, making high-speed high-resolution MRSI possible for practical applications.
		Computer Number: 79 2944. Evaluating real-world performance of retrospective frequency correction in large samples for single-voxel MR spectroscopy at 7T View Presentation Video C-Y Lee, J. Xu, B. Yang, V. Magnotta The University of Iowa, Iowa City, United States Impact: This study demonstrates subjection motion-induced frequency changes affect certain metabolites with small concentrations rather than affecting major metabolites as in the presence of gradient heating-induced frequency drift. The resulting increased rCRLB of metabolites can be mitigated using retrospective frequency corrections.
		Computer Number: 80 2945. An initial report of quantitative analysis of segmented whole-brain MRSI in epilepsy View Presentation Video H. Shayeste, S. Chambers, P. Lazen, M. Tomschik, J. Wais, G. Kasprian, L. Haider, L. Hofer, C. Baumgartner, J. Koren, M. Feucht, C. Dorfer, E. Pataraia, W. Bogner, S. Trattnig, K. Rössler, G. Hangel Department of Neurosurgery, Medical University of Vienna, Vienna, Austria Impact: For the first time, we established regional concentration estimates of neurochemicals in epilepsy patients using 7T MRSI. Detecting abnormal concentrations could improve the diagnostic performance in MR-negative patients.

Similar Session(s)

Back to Meeting Home Back to the Program-at-a-Glance

The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.