ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Digital Poster

Magnetization Transfer Imaging

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Magnetization Transfer Imaging
Digital Poster
Contrast Mechanisms
Monday, 12 May 2025
Exhibition Hall
16:00 -  17:00
Session Number: D-93
No CME/CE Credit

 
Computer Number: 49
2006. Optimization of Inhomogeneous Magnetization Transfer Imaging on a Fully Myelinated Tract
P. Labouré, F. Geffroy, L. Ciobanu
Neurospin, Gif-Sur-Yvette, France
Impact: This study enhances our understanding of ihMT’s sensitivity and specificity to myelin, paving the way toward optimized acquisition parameters and the development of a standardized protocol.
 
Computer Number: 50
2007. Universal versus subject-specific parallel transmit pulses for inhomogeneous magnetization transfer at 7T
M. Lam, V. Gras, M. Couch, C. Rowley, C. Tardif
McGill University, Montreal, Canada
Impact: To enable high-resolution whole-brain ihMT imaging at 7T, we require dual and single off-resonance pulses that produce a spatially uniform saturation. Our simulations showed improved ihMT uniformity using subject-specific and universal pre-saturation pTx pulses to a range comparable to 3T.
 
Computer Number: 51
2008. Simultaneous measurement of water, MT, CEST, myelin water fraction, and susceptibility contrast using rosette-accelerated MR fingerprinting
S. Z. Mahmud, H-Y Heo
The Johns Hopkins University School of Medicine, Baltimore, United States
Impact: A rosette-accelerated, multi-parametric MRF technique efficiently assesses various tissue parameters that serve as candidate biomarkers, providing valuable insights into a range of pathologies. 
 
Computer Number: 52
2009. Optimization of acquisition schedules and correction of B0 and B1 field inhomogeneities in saturation transfer MR fingerprinting (ST-MRF)
B. Kang, M. Singh, H. Seo, H. Park, H-Y Heo
Korea Institute of Science and Technology (KIST), Seould , Korea, Republic of
Impact: The proposed optimal ST-MRF approach could provide accurate and reliable multi-tissue parameter maps from a single scan within clinical acceptable time, even in the presence of the severe B0 and B1 field inhomogeneities.
 
Computer Number: 53
2010. Quantitative Macromolecular Proton Fraction Imaging using Pulsed Spin-Lock
Q. Shan, Z. Yu, B. Jiang, Q. Shen, J. Hou, Q. Chan, W. Chu, V. Wong, W. Chen
The Chinese University of Hong Kong, Hong Kong, China
Impact: The technical can improve SNR of MPF-SL under typical RF hardware constrain and provide more reliable and robust MPF mapping in vivo. 
 
Computer Number: 54
2011. Orientation-independent magnetization transfer measurement of white matter in brain
Z. Gao, Z. Zhou, Z. Yu, J. Hou, Q. Shan, W. Chen
The Chinese Univeristy of Hong Kong, Hong Kong, Hong Kong
Impact: The MPF-SL technique provides a potential solution for orientation-independent magnetization transfer measurement of white matter in human brain. 
 
Computer Number: 55
2012. Magnetization Transfer Knee Imaging at 0.05 Tesla with Extremely Low SAR
S. Su, Y. Ding, V. Lau, J. Hu, J. Zhang, X. Lin, L. Wu, A. Leong, Y. Zhao, E. Wu
The University of Hong Kong, Hong Kong SAR, China
Impact: MT knee imaging is demonstrated at 0.05 Tesla for the first time. Strong MT effects have been observed in articular cartilage with an extremely low SAR of 3.1mW/kg, rendering the potential of ULF MT knee imaging for articular cartilage evaluation.
 
Computer Number: 56
2013. Impact of Ozempic on Adipose Tissue in Obese Mice: A Quantitative Study Using Dixon and MT MRI Methods, DEXA and CT.
O. Aristizabal, D. Abbadi, O. Mishkit, N. Rahman, R. Schneider, Y. Zaim-Wadghiri
NYU Grossman School of Medicine, New York, United States
Impact: This study highlights an advanced MRI protocol's potential for precisely assessing body composition, showing that Semaglutide improves muscle health by increasing lean tissue and reducing fat. This non-invasive imaging approach could significantly enhance monitoring in metabolic health interventions.
 
Computer Number: 57
2014. Investigation on Water Dynamics in Cell Swelling
S-M Kim, K. Min, J. S. Lee, J-Y Park
Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of
Impact: This study elucidates the water dyanmics associated with cell swelling using MRI, particualrly showing differences between two different mechanisms of cell swelling, which will contribute significantly to a better understanding of cell physiology and function.
 
Computer Number: 58
2015. Robust extrapolated semi-solid magnetization transfer reference fitting for amide proton transfer (APT) imaging quantification
J. Wu, K. Chai, P. Wang, Z. Zhang, J. Zhou, S. Jiang
Johns Hopkins University, Baltimore, United States
Impact: The proposed method enabled more robust APT imaging quantification, which provides stronger APT signal intensity values than traditional MTR asymmetry analysis. Preliminary results proved its effectiveness in distinguishing treatment effect and tumor recurrence and more applications are expected. 
 
 
Computer Number: 59
2016. Fat-suppressed ultrashort echo time magnetization transfer (UTE-MT) modeling via subtraction of fat-selective image
S. H. Shin, A. Suprana, J. Lo, J. Wang, D. Berry, E. Chang, J. Du, Y. Ma
UC San Diego, La Jolla, United States
Impact: The fat-suppressed UTE-MT method shown in this study will improve the accuracy of quantifying molecular compositions of short-T2 tissues. This fat suppression method also has the potential to be applied to other UTE-based quantitative MR techniques.
 
Computer Number: 60
2017. Investigating ihMT T1D-filtering imaging for characterizing demyelination and inflammation processes in MS lesions
G. Duhamel, T. Anderson, A. Hertanu, L. Soustelle, L. de Rochefort, L. Pini, G. Varma, D. Alsop, J. Pelletier, O. Girard
Aix Marseille Univ, CNRS, CRMBM, Marseille, France
Impact: Semi-quantitative measures of the density of myelin and that of other macromolecules can be obtained with a single MR experiment using ihMT T1D filtering. This technique might be used to characterize demyelination and processes of inflammation in MS lesions.
 
Computer Number: 61
2018. The role of incidental magnetization transfer in divided subtracted inversion recovery
M. Bydder, T. Melzer, N. Palmer, P. Condron, D. Cornfeld, E. Kwon, M. Tayebi, G. Newburn, M. Scadeng, S. Holdsworth, G. Bydder
Mātai Medical Research Institute, Gisborne, New Zealand
Impact: This study identifies a plausible mechanism for dSIR signal changes in white matter that may lead to more efficient methods of detecting mTBI and hypoxic injuries.
 
Computer Number: 62
2019. Reducing ihMT acquisition time using alternating single frequency MT preparation and variable flip angle readouts
G. Varma, A. Grant, L. Soustelle, O. Girard, G. Duhamel, D. Alsop
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States
Impact: We demonstrate frequency alternating at low duty cycle MT and variable flip angle readouts significantly improve ihMT by reducing scan time and/or increasing resolution. These developments allow for easier clinical translation and will improve utility in neurological studies of myelin.
 
Computer Number: 63
2020. CEST perspectives for human brain applications at 11.7 T
C. Ressam, V. Gras, F. Mauconduit, L. Ciobanu
NeuroSpin CEA Paris-Saclay, Université Paris-Saclay, Gif-sur-Yvette, France
Impact: This study explores the potential of using the 11.7 T scanner for human brain CEST applications, addressing B1+ inhomogeneities and SAR compliance. It marks a first step toward clinical evaluation of CEST at magnetic fields higher than 7 T. 
 
Computer Number: 64
2021. Reproducible liver CEST Imaging at 7 T with B1+ shimming
P. Bulanov, P. Menshchikov, J. Grimm, M. Lutz, S. Orzada, P. Boyd, P. Bachert, M. Ladd, A. Korzowski, S. Schmitter
Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Impact: In this study, to the best of our knowledge, we have successfully demonstrated for the first time the robust and reliable acquisition of relaxation-compensated CEST contrasts (i.e., MTRRex of amide, rNOE and guanidino) of the human liver at ultra-high fields.
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