ISMRM25 - Emerging Contrast Mechanisms & Applications

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Emerging Contrast Mechanisms & Applications

Digital Poster

Contrast Mechanisms

Wednesday, 14 May 2025

Exhibition Hall

13:30 - 14:30

Session Number: D-96

No CME/CE Credit

		Computer Number: 33 3532. Microstructural Heterogeneity of Tissues Revealed by High-Resolution MR Microscopy at 15.2 T View Presentation Video B. Dhakal, B. Hardy, A. Anderson, M. Does, J. Xu, J. Gore Vanderbilt University Medical Center, Nashville, United States Impact: The study offers insight into T₁ relaxation and spin exchange dynamics at the microscopic level.
		Computer Number: 34 3533. Direct detection of peripheral nerve and skeletal muscle activity via spin-lock based MRI: a simulation and phantom study View Presentation Video C. Schäfer Gómez, P. Albertova, T. Kampf, P. Nordbeck, P. Jakob, M. Pham, M. Schindehütte, M. Gram University Hospital Würzburg, Würzburg, Germany Impact: This study extends the concept of SL-based detection of neural oscillations and cardiac-induced biomagnetism to the peripheral nervous system. This innovation could pave the way for non-invasive, high-resolution localization of peripheral nerve disorders using MRI, enhancing diagnostics in clinical routine.
		Computer Number: 35 3534. Generation of Realistic MR Elastography Brain Stiffness Map Mimics using a 3D Conditional Generative Adversarial Network View Presentation Video M. Kroen, C. Johnson University of Delaware, Newark, United States Impact: This work demonstrates that a generative adversarial network can produce realistic brain stiffness images. Improvements to this technique will allow for these images to be used alongside true MRE images to support computational modeling efforts which utilize brain stiffness information.
		Computer Number: 36 3535. Applying Phosphorous Cross-Polarization/Magnetization Transfer to Probe the Membrane/Water Interface in Myelin View Presentation Video C-A Knight, A. Ensworth, C. Laule, A. MacKay, C. Michal University of British Columbia (UBC), Vancouver, Canada Impact: Detecting membrane-specific ³¹P and ¹H_s NMR signals through MRI-visible ¹H_aq could provide new and extremely specific MRI contrast mechanisms for myelin, providing superior sensitivity to membrane condition than existing proton-only metrics.
		Computer Number: 37 3536. Lymphatic system imaging manifestations of lymphangioleiomyomatosis X. Li Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, China Impact: Both PLCT and NCMRL are effective for detecting abnormalities in the LAM lymphatic system. The combined use of HRCT and NCMRL plays an important role in detecting lymphatic system imaging abnormalities, and PLCT can be used as an alternative examination.
		Computer Number: 38 3537. Impact of Curl Operation on Stiffness Estimation in Brain MR Elastography View Presentation Video K. Pavuluri, A. Arani, J. D. Trzasko, M. L. Senjem, J. Huston III, R. L. Ehman, A. Manduca, M. C. Murphy Mayo Clinic, Rochester, Rochester, United States Impact: The findings provide insights for selecting MRE processing methods, indicating that while curl-based methods improve shear wave isolation, gradient-based approaches may serve as better training data for capturing stiffness variations in structurally complex, inhomogeneous tissues.
		Computer Number: 39 3538. Development of a Novel Vibration Pad for Accurate Renal MR elastography View Presentation Video Y. Ishihara, T. Numano, D. Ito, H. Nishijo, K. Takamoto, T. Habe, H. Oka, K. Yamada Tokyo Metropolitan University, Tokyo, Japan Impact: The eGFR, a common index of renal function, fluctuates with muscle mass, diet, and physical activity, which can lead to inaccurate evaluation of renal function. Therefore, measuring renal stiffness using MRE could serve as a novel biomarker for CKD.
		Computer Number: 40 3539. Assessing the Reliability of SE-EPI MRE for Liver Stiffness Estimation Under Free-Breathing Instruction Compared to Breath-Holding View Presentation Video T. Delgado, S. Kafali, B. Bolster Jr., L. Jiang, S-F Shih, K. Johnson, P. Itriago Leon, M. Altbach, V. Deshpande, D. Lu, S-H Han, H. Wu David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States Impact: Free-breathing SE-EPI MRE without explicit motion compensation provides reliable mean LS estimates comparable to breath-holding scans, enabling rapid liver stiffness assessment in patients with difficulty performing breath-holding.
		Computer Number: 41 3540. Fingerprint of in vivo histology MRI in drug-resistant temporal lobe epilepsy patients View Presentation Video S. Mohammadi, N. Sura, L. Mordhorst, N. Lüthi, J-M Oeschger, B. Fricke, O. Ohana, M. Callaghan, N. Weiskopf, I. Jelescu, F. Szczepankiewicz8, A. Chakwizira, D. Carmichael, J. Marques, M. Nilsson, T. Sauvigny, F. Fritz Lübeck University, Lübeck, Germany Impact: Novel MRI contrasts can improve our understanding of lesion microstructure in epilepsy. This study shows consistent fingerprints of hMRI metrics across two patients with different MR-clinical findings, indicating that hMRI might complement clinical MRI by revealing information about tissue microstructure.
		Computer Number: 42 3541. Optimize Difference (OpDiff): Contrast Enhancement Ordinary Differential Equations for Sub-Second Liver DCE-MRI Reconstruction View Presentation Video C. Guo, T. Fraum, H. An Washington University in St. Louis, St. Louis, United States Impact: This novel image acquisition and reconstruction approach could improve the accuracy of early post-contrast phase timing for liver DCE-MRI.
		Computer Number: 43 3542. Myelin Water Fraction Orientation Dependence: An Ex-Vivo 9.4T Human Spinal Cord Study View Presentation Video T. Joseph, K. Bale, A. Yung, S. Morris, P. Kozlowski, P. Mattu, L. Parker, K. Dong, F. Streijger, G. R. W. Moore, A. Velenosi, V. Hirsch-Reinshagen, B. Kwon, I. Vavasour, C. Laule University of British Columbia, Vancouver, Canada Impact: We observed variations in myelin water fraction (MWF) at different cord orientations relative to the B₀ field, suggesting that MWF is dependent on fiber orientation. Further work should focus on methods to correct for orientation dependence when scanning in-vivo.
		Computer Number: 44 3543. Determination of the R2=1/T2 relaxation rate of myelin and pure phospholipids using molecular dynamics simulations View Presentation Video A. Ajouz, H. Neeb UKSH, CAU Kiel, Kiel, Germany Impact: MD simulations allow for the investigation of transverse relaxation in lipid systems and thus provide a model-based determination of $$$R_{2}$$$ and linewidth of lipid bilayer structures.
		Computer Number: 45 3544. Brain T1 Relaxation Time Changes After Acute Exercise View Presentation Video X. Hu, Z. Zhou, H. Qi, W. Yang, P. Hu ShanghaiTech University, Shanghai, China Impact: We found that a single session of aerobic exercise can induce significant and region-specific T1 changes in the brain, offering a novel perspective for brain studies in addition to current functional and perfusion MRI.
		Computer Number: 3545. WITHDRAWN
		Computer Number: 46 3546. MRI Relaxation rates of fecal microbiota from porcine stool samples and their relationship to essential metals View Presentation Video G. VM, Q. Sun, S. Parvathy, S. Hong, O. Olasode, D. Diksha, S. Donnelly, J. Burton, D. Goldhawk, F. Prato, G. Moran, N. Gelman Lawson Research Institute, London, Canada Impact: With further validation, this could significantly impact the scope of clinical applications for abdominal MRI towards the detection of gut bacteria given their metal content.
		Computer Number: 47 3547. Evaluating 3D-EPI and FLASH-based multi-parameter mapping in temporal lobe epilepsy: a traveling head study View Presentation Video N. Lüthi, F. Fritz, L. Mordhorst, L. Edwards, K. Pine, N. Weiskopf, D. Wang, T. Stöcker, R. Stirnberg, M. Callaghan, P. Bridgen, Z. Ning, S. Malik, D. Leitão, D. Carmichael, S. Mohammadi University of Lübeck, Lübeck, Germany Impact: We demonstrate the potential of using 3D-EPI for efficient MPM acquisition for characterising regional differences in epileptogenic regions. However, it´s unclear whether our results translate to detecting subtle abnormalities in clinical application due to, e.g. reduced spatial resolution of 3D-EPI.

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