ISMRM25 - Hyperpolarization (Non-Gas): New Developments

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Hyperpolarization (Non-Gas): New Developments

Digital Poster

Contrast Mechanisms

Thursday, 15 May 2025

Exhibition Hall

13:15 - 14:15

Session Number: D-97

No CME/CE Credit

		Computer Number: 49 4475. D2O vs H2O Dissolutions for Enhancing Human MR Imaging of Hyperpolarized [2-13C]Pyruvate Conversions to Glutamate and Lactate View Presentation Video Y. Kim, I. Shkliar, D. Dang, T. Nickles, E. Escobar, S. Andosca, R. Bok, J. Gordon, D. Vigneron University of California, San Francisco, San Francisco, United States Impact: Dissolving hyperpolarized [2-¹³C]pyruvate in D₂O instead of H₂O increased T₁, yielding higher polarization for human MRI studies. This approach is expected to improve the quality of hyperpolarized [2-¹³C]pyruvate MRI, enabling more accurate assessments of oxidative & glycolytic metabolism of pyruvate.
		Computer Number: 50 4476. Optimization of a [1-13C]pyruvic acid sample preparation for clinical hyperpolarization View Presentation Video J-N Hyacinthe, K. Yeung, T. Lê, D. Tyler, J. Grist, A. Capozzi EPFL, Lausanne, Switzerland Impact: Hyperpolarized-MRI diagnostic capability depends on the initial polarization of the contrast agent. Clinical polarizers are complex and expensive machines. We propose an easy to implement optimized sample preparation leading to a 50% SNR increase without any hardware modification.
		Computer Number: 51 4477. Design and development of a transmit RF coil for large field of view hyperpolarized 13C imaging View Presentation Video A. Chen, T. Ishiguro, F. Robb, D. Anderson, T. Thomas, J. Vincent, V. R. Malasani, V. Taracila, T. Grafendorfer, E. Baus, T. Stickle, A. Nozaki, J. Lau, A. Comment, C. Cunningham, K. Keshari GE Healthcare, Taichung , Taiwan Impact: The 13C transmit coil developed in this project provides uniform RF excitation across a large FOV without compromising patient comfort and the 1H imaging. It will be an integral element for routine clinical HP 13C metabolic imaging in the future.
		Computer Number: 52 4478. On The Optimal Readout Trajectory for Hyperpolarised 13C Metabolic Imaging View Presentation Video R. Schulte, E. Hansen, J. Gordon, C. Cunningham, A. Chen, P. Larson, M. Fuetterer, A. Comment, C. Laustsen GE HealthCare, Munich, Germany Impact: ¹³C metabolic imaging provides valuable clinical information, such as tumour-treatment response, and may complement or provide an alternative to PET. For clinical studies, it is important to choose the optimal sequence.
		Computer Number: 53 4479. Advancing 13C Metabolic MRSI: Enhanced Imaging Techniques and an effective standardized Phantom at 11.7 T View Presentation Video J. Schüle, T. Speidel, C. A. Müller, S. Lucas, V. Rasche Ulm University Medical Center, Ulm, Germany Impact: The construction of a stable and reliable phantom with high homogeneity containing ¹³C-reference solutions enables standardized sequence optimization for hyperpolarized MRSI experiments. For preclinical in-vivo studies, single reference solutions can further be used for calibration measurements.
		Computer Number: 54 4480. Fast 3D Hyperpolarized Carbon-13 Metabolic MRI with Enhanced Spatio-Temporal Resolution Using Radial Multi-Echo bSSFP and PSF Optimization View Presentation Video Z. Wang, C. Müller, J. Fischer, M. Grashei, S. Sühnel, N. Setzer, F. Schilling, M. Awenius, A. Korzowski, A. Özen, M. Zaitsev, M. Bock, A. Schmidt Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg im Breisgau, Germany Impact: Dynamic hyperpolarized ¹³C MRSI imaging is optimized by a sliding-window technique, producing high-resolution dynamic images and improving kinetic model fitting. The approach optimizes trade-offs between spectral, spatial, and temporal resolution in HP ¹³C metabolic MRI.
		Computer Number: 55 4481. Joint Optimization of Data Sampling and Reconstruction for Highly Accelerated Cartesian 2D+time Hyperpolarized MRI with AutoSamp View Presentation Video T. Nickles, C. Alkan, H-Y Chen, Y. Kim, P. Larson, J. Pauly, D. Vigneron, J. Gordon University of California San Francisco , San Francisco, United States Impact: Asymmetrical PF encoding of 2D dynamic HP [1-¹³C]pyruvate MRI benefits from low-rank recovery reconstruction methods to ensure image fidelity, and to increase SNR by reducing T₂* weighting.
		Computer Number: 56 4482. Modular integration of spatial-spectral selective excitation into Bruker Singlepulse, Flash, and EPI for metabolite selective HP 13C MRSI View Presentation Video C. Müller, J. Schüle, S. Hedge, A. Marshall, J. Gaubatz, L. Nagel, P. Rütten, S. Machnes, F. Schilling, V. Rasche, I. Schwartz NVision Imaging Technologies GmbH, Ulm, Germany Impact: A modular framework for spatial-spectral excitation with Bruker product methods was implemented. The framework can assist MRI researchers to evaluate possible RF & gradient shapes for a specified metabolite-selective MR exam.
		Computer Number: 57 4483. A combined hemodynamic and metabolic model for in vivo hyperpolarized 13C MRI data analysis View Presentation Video N. Christensen, N. Jespersen, N. Bøgh, E. Hansen, H. Wiggers, S. Jespersen, C. Laustsen Aarhus University, Aarhus, Denmark Impact: Our generalized model potentially enables more accurate quantification of metabolism in HP ¹³C-MRI by accounting for perfusion and extraction effects. This advancement may support better interpretation of metabolic data, potentially leading to improved diagnostics and therapeutic monitoring in clinical settings.
		Computer Number: 58 4484. Kinetic Modeling of HP [1-13C]-Pyruvate Determines Dominant Physiological Parameters Influencing Lactate to Pyruvate AUC Ratio View Presentation Video R. Boyce, C. Harlan, Q. Wang, C. Walker, S. Lai, M. Merritt, J. Bankson University of Texas MD Anderson Cancer Center, Houston, United States Impact: The proposed analysis has the potential to aid in the analysis of [1-13C]-pyruvate studies by distinguishing between the effects of pyruvate delivery to the cells and true Warburg metabolism in tumors.
		Computer Number: 59 4485. >106 x enhancement of 13C-enriched pyruvate via in situ hyperpolarization in an ultra-low field MRI scanner View Presentation Video T. Boele, S. McBride, P. TomHon, D. Waddington, T. Theis, M. Rosen Image X Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia Impact: These results are the first demonstration of ¹³C hyperpolarization generated and measured in situ at 6.5mT and showcase the flexibility and utility of SLIC SABRE as a hyperpolarization method to drive widespread adoption of ¹³C metabolic MRI in the clinic.
		Computer Number: 60 4486. 3D virtual biopsy of in vivo pH and metabolism using semi-LASER MRS of hyperpolarized 13C nuclei View Presentation Video W. Gottwald, L. Nagel, M. Grashei, S. Sühnel, F. Gaksch, S. Bauer, N. Setzer, G. Topping, F. Schilling TUM School of Medicine and Health, Department of Nuclear Medicine, TUM University Hospital, Munich, Germany Impact: We show for the first time the use of adiabatic refocusing pulses for hyperpolarized ¹³C multi-voxel MRS to detect pH and metabolism, with high spectral resolution and short acquisition time, while maintaining high spatial customizability.
		Computer Number: 61 4487. Novel Applications of Generalized MR Image Reconstruction via Direct Pseudoinversion of the Encoding Matrix (Pinv-Recon) View Presentation Video K. Yeung, F. Gleeson, R. Schulte, A. McIntyre, S. Serres, P. Morris, D. Auer, D. Tyler, F. Wiesinger, J. Grist University of Oxford, Oxford, United Kingdom Impact: Highlighting the application of generalized MR image reconstruction via direct pseudoinversion of the encoding matrix (Pinv-Recon) to hyperpolarized MRI and emphasizing its feasibility with modern computational infrastructure, ease of implementation, and advantages over conventional FFT-based approaches.
		Computer Number: 62 4488. In vivo imaging of 15N-Betaine: A long-lived, endogenous molecular contrast agent for hyperpolarized MRI View Presentation Video I. Skre, M. Karlsson, R. Olin, M. Lerche Technical University of Denmark (DTU), Kongens Lyngby, Denmark Impact: We introduce ¹⁵N-Betaine, a long-lived endogenous molecular contrast agent for hyperpolarized MRI, demonstrating feasibility for in vivo imaging. Its extended signal-lifetime supports prolonged acquisitions and enables flexible protocols with adaptable timing and resolution, offering a new tool for molecular imaging.
		Computer Number: 63 4489. Increasing 15N and 13C polarization in parahydrogen-induced polarization relayed via proton exchange. View Presentation Video K. Them, J. Kuhn, A. Pravdivstev, J-B Hövener University Medical Center Schleswig-Holstein , Kiel, Germany Impact: The findings pave the way to develop a pH2-based method that can strongly polarize 13C and 15N nuclei of a wide range of biomolecules playing an important role in metabolic MR imaging. Scientists may try to use new imaging agents.
		Computer Number: 64 4490. Fast PHIP-based hyperpolarization of 13C 𝛂-ketoacids using POLARIS: high polarization, reproducibility, and in vivo results View Presentation Video M. Chaumeil, L. Nagel, Z. Ahmadova, M. Gierse, M. Grashei, J. Handwerker, F. Josten, S. Karaali, C. Rooney, P. Ruetten, P. Wolff, I. Schwartz, F. Schilling, S. Knecht NVision Imaging Technologies, Ulm, Germany Impact: POLARIS enables rapid, reproducible and high polarization of 13C-labeled 𝛂-ketoacids with an easy-to-use, highly automated workflow. This breakthrough enables fast, reproducible results, paving the way for extensive, consistent studies that will significantly advance the field of hyperpolarized MRI.

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