ISMRM25 - Hyperpolarization (Non-Gas): Applications

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Hyperpolarization (Non-Gas): Applications

Digital Poster

Contrast Mechanisms

Thursday, 15 May 2025

Exhibition Hall

14:15 - 15:15

Session Number: D-98

No CME/CE Credit

		Computer Number: 65 4649. Increased infusion times of hyperpolarized pyruvate in D2O maintain hyperpolarized lactate generation and approach steady state metabolism View Presentation Video P. Porcari, T. Peyear, S. Patel, M. Berishaj, V. Miloushev, K. Keshari Memorial Sloan Kettering Cancer Center, New York, United States Impact: The combination of [1-¹³C]pyruvate in D₂O, with elongated T₁, and increasing injection times demonstrated an extended hyperpolarized steady level for both [1-¹³C]pyruvate and [1-¹³C]lactate in a mouse brain, leading to a more robust metabolic imaging with straightforward clinical application.
		Computer Number: 66 4650. Hyperpolarized 13C metabolic MRI of tumor xenografts in fertilized chicken eggs View Presentation Video M. Kirst, T. Lobmeyer, R. Ranjan, S. Sühnel, V. Kern, N. Setzer, L. Nagel, G. Topping, S. Knecht, Z. Ahmadova, S. Karaali, I. Schwartz, M. Reichert, V. Rasche, F. Schilling TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany Impact: This study shows for the first time hyperpolarized ¹³C metabolic MRI of a murine tumor transplant in a fertilized chicken egg. A further validation of this method for different patient-derived tumor transplants could yield further insights for personalized medicine.
		Computer Number: 67 4651. Initial Experiences with Hyperpolarized [1-13C] Pyruvate MRI In Hepatocellular Carcinoma Patients View Presentation Video U. Kjærgaard, N. Bøgh, M. Aastrup, M. Kristensen, N. Christensen, K. Sivesgaard, S. Ringgaard, L. Bertelsen, E. Hansen, H. Grønbæk, G. Villadsen, C. Laustsen Aarhus University, Aarhus N, Denmark Impact: Hyperpolarized MRI in patients with HCC is feasible and may be used to detect early HCC and might characterize glutaminase synthase positive tumors non-invasively by increased alanine production.
		Computer Number: 68 4652. Hyperpolarized 1-13C Pyruvate Magnetic Resonance Spectroscopy Distinguishes Hepatocellular Carcinoma Genetic Subgroups In Vivo. View Presentation Video B. Adebesin, D. Tischfield, A. Zavriyev, M. Sheehan, A. Islam, V. Shattuck, D. Ackerman, S. Kadlecek, T. Gade University of Pennsylvania, Philadelphia, United States Impact: CTNNB1 mutant and non-mutant HCCs can be distinguished non-invasively by assessing Hyperpolarized-1-¹³C-Pyruvate flux to Alanine and Lactate. Our findings present a promising precision imaging strategy for patient stratification, with the potential to enhance treatment outcomes in HCC and other cancers.
		Computer Number: 69 4653. Evaluating hepatic metabolic derangements in a diet and oxidative stress induced mouse model of MASLD with hyperpolarized [1-13C]-pyruvate View Presentation Video A. Cho, S-H Lin, M. Inigo-Volmer, M. Mizerska, M. Villegas, S. Hammer, X. Wen, N. Browder, Z. Erfani, J. M. Park, C. Malloy, S. Burgess University of Texas Southwestern Medical Center, Dallas, United States Impact: Our results demonstrate that HP [1-¹³C]-pyruvate is a promising molecular imaging probe for the non-invasive diagnosis of simple steatosis/MASH and potentially offers a safe alternative to liver biopsy that is more appropriate for longitudinal disease monitoring.
		Computer Number: 70 4654. Hyperpolarized 13C MRS detects brain metabolic alterations in a tauopathy model of Alzheimer’s disease View Presentation Video N. Vidas-Guscic, C. Leo, M. Heady, A. Shaw, C. Von Morze, J. Ulrich, A. Chaney, C. Guglielmetti Washington University School of Medicine, Saint Louis, United States Impact: We demonstrated that hyperpolarized ¹³C MRS has potential to monitor impaired oxidative metabolism in the brain of a clinically relevant AD model. Upon clinical translation, this method could improve diagnosis and monitoring of AD progression, and the assessment of therapies.
		Computer Number: 71 4655. Early detection of diabetic nephropathy using compartment-specific hyperpolarized 13C metabolic readouts View Presentation Video C. von Morze, A. Shaw, T. Blazey Washington University, St Louis, United States Impact: Precise metabolic measurements obtained non-invasively by HP 13C MRI with multiple co-HP metabolic substrates, whose activities are localized to distinct cellular compartments, could enable early detection of diabetic kidney damage.
		Computer Number: 72 4656. Preliminary results of the utility of Hyperpolarized [1-13C]pyruvate MRI in patients with Autosomal Dominant Polycystic kidney disease. View Presentation Video M. Aastrup, U. Kjærgaard, E. Søvnsø Szocska Hansen, N. Bøgh, R. Hansen, C. Holt, L. Bertelsen, S. Ringgard, J. Jensen, N. H. Buus, C. Laustsen The MR Research Centre, Aarhus N, Denmark Impact: The metabolic signatures and images obtained from HP ¹³C MR may help monitoring disease progression in autosomal-dominant-polycystic-kidney-disease (ADPKD) and chronic kidney disease (CKD) and increase knowledge of pathological elements in these diseases.
		Computer Number: 73 4657. Evaluating the metabolic effects of neoadjuvant treatment in clear cell renal cell carcinoma using hyperpolarised [1-13C]pyruvate-MRI View Presentation Video I. Horvat-Menih, M. McLean, J. Birchall, M. J. Zamora Morales, M. Wylot, A. Grimmer, E. Latimer, A. Khan, A. Priest, A. Gill, J. Kaggie, M. Graves, T. Barrett, A. Warren, B. O'Carrigan, J. Jones, S. Welsh, T. Mitchell, A. Riddick, J. Armitage, G. Stewart, F. Gallagher University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Impact: HP ¹³C-MRI may be an independent early biomarker for RCC treatment response. Detection of differential metabolic changes before morphological and function changes on MRI may help to tailor treatments earlier, potentially saving lives and reducing costs.
		Computer Number: 74 4658. Visualization of Brain Metabolic Changes in Ulcerative Colitis Model Mice Using Hyperpolarized 13C MRI with PHIP-SAH Technique. View Presentation Video R. Mochizuki, H. Hirata, S. Matsumoto Information Science and Technology, Hokkaido University, Sapporo, Japan Impact: Non-invasively detectable alteration of brain pyruvate metabolism by parahydrogen-polarized 13C MRI in ulcerative colitis mice can be a useful biomarker of depression and cognitive impairments induced by inflammatory bowel disease such as ulcerative colitis.
		Computer Number: 75 4659. Targeting metabolism to interrogate immunotherapy resistance in melanoma and predicting therapy efficacy employing HP-MRSI View Presentation Video S. Pudakalakatti, G. Murley, W. Padron, J. Delacerda, A. Morales, M. Wang, R. Chin, W. Schuler, J. Enriquez, K. Rai, M. Pagel, P. Bhattacharya University of Texas MD Anderson Cancer Center, Houston, United States Impact: The research demonstrates an innovative image-driven pathway to sensitize immunotherapy-resistant melanoma in a preclinical setting. We have shown early efficacy, reduced tumor growth, and improved survival in mice treated with an MCT inhibitor and ICB and interrogated these using HP-MRSI.
		Computer Number: 76 4660. Hyperpolarized 13C bicarbonate-to-pyruvate ratio correlates with excitatory neuron spatial distribution in the human brain View Presentation Video B. Uthayakumar, N. Cappelletto, N. Bragagnolo, D. Dingwell, J. Gillis, A. Chen, H. Soliman, C. Cunningham University of Toronto, Toronto , Canada Impact: We found that there was a pattern of neuron cell distribution in the healthy brain that correlates with hyperpolarized ¹³C-signal topography. These results provide a better understanding of the physiology driving hyperpolarized 13C-signal patterns in healthy human brains.
		Computer Number: 77 4661. Hyperpolarized [2-13C]pyruvate provides an early readout of response to precision therapy in mutant IDH gliomas View Presentation Video G. Batsios, A. M. Gillespie, P. Viswanath University of Caifornia, San Francisco, San Francisco, United States Impact: Our studies indicate that hyperpolarized [2-¹³C]pyruvate MRI interrogates early response to targeted therapy in IDHm gliomas. Clinical translation of hyperpolarized [2-¹³C]pyruvate will provide clinicians with a much-needed tool to monitor disease progression in IDHm glioma patients, which is currently challenging.
		Computer Number: 78 4662. Multi-parametric hyperpolarized imaging of renal ischemia reperfusion injury A. Zavriyev, J. Nguyen, B. Adebesin, M. Sheehan, D. Boehmler, J. Yu, A. Islam, Z. Wang, G. Ge, E. Hartung, M. Levine, S. Kadlecek, T. Gade University of Pennsylvania, Philadelphia, United States Impact: Our results suggest that co-polarized pyruvate and urea imaging could serve as a sensitive diagnostic tool to distinguish IRI severity. Additionally, the feasibility of lysine imaging suggests the potential to enhance the specificity of HP imaging for renal IRI diagnosis.
		Computer Number: 79 4663. The Influence of Fasting and Anesthesia on Cerebral Metabolism of Hyperpolarized Pyruvate View Presentation Video T. Lê, A. Capozzi, J-N Hyacinthe, M. Mishkovsky EPFL, Lausanne, Switzerland Impact: Fasting and anesthesia influence brain metabolism and consciousness. Higher pyruvate-to-lactate turnover is observed in mice under isoflurane-only than medetomidine-isoflurane anesthesia. Besides the relevance for preclinical studies, this opens opportunities for probing brain biochemistry in anesthetized patients and influence of fasting.
		Computer Number: 80 4664. Probing Metabolite Compartmentalization in the Mouse Brain with Hyperpolarized Diffusion-weighted Imaging View Presentation Video G. Zhang, K. Keshari Memorial Sloan Kettering Cancer Center, New York, United States Impact: The application of a diffusion-weighted, multi-shot, multi-echo EPI sequence to differentiate metabolite compartmentalization in the brains of healthy mice, indicating the capability of the method to provide deeper insights into cellular metabolic processes and mechanisms of transport.

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