MRI of the Resting Brain: Influence of Sleep & Anesthesia on Brain
Physiology & Neurofluid Dynamics
Member-Initiated Session
Wednesday, 14 May 2025
Session Number: MIS-05
No CME/CE Credit
Overview:
Brain function changes dramatically across arousal states, as sleep and
anesthesia alter physiology and fluid flow in the brain. Sleep and
anesthesia modulate brain waste clearance, and have been implicated in
the development of neurodegenerative disorders. This is a new and
rapidly emerging field with many open questions in how arousal modulates
physiology, and how to interpret this in the context of disease.
Moreover, many practical challenges are faced when studying sleeping
subjects inside an MRI scanner; similarly it is challenging to scan
rodents in states reflecting sleep and awakeness. There is now wide
interest in developing and using imaging techniques that can track brain
physiology across states and yield insight into neurological
dysfunction. This symposium will provide the key information needed to
accelerate MRI work in this field. Speakers will provide an overview of
biological concepts for how brain fluids are regulated, and preclinical
data demonstrating effects of sedation on brain clearance. Speakers will
discuss in-depth practical guidance on how to perform these types of MRI
studies, and integrate multimodal information to image sleep and
sedation states. Multiple cutting-edge MRI techniques for imaging these
processes will be presented, including diffusion, fast fMRI, MREG, and
tracer infusions. Finally, we will discuss the clinical relevance of
these emerging methods, particularly in the context of neurodegenerative
disorders.
Target Audience:
MR physicists developing neurofluids methods; MR application users
seeking to understand neurofluid dynamics and/or conduct studies of
different brain
Learning Objectives:
Upon completion of this activity, participants should be able to:
• Learn how to conduct MRI studies across arousal states;
• Learn the current state-of-the-art MRI methods for tracking brain
physiology across arousal states; and
• Learn recent updates on how neurological disorders are linked to
sleep-related brain physiology measured with MRI.
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13:30 |
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Introduction to Cerebral Waste Clearance & Diffusion MR
Techniques for Imaging Neurofluids
Merel van der Thiel
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13:54 |
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Emerging Methodological Development From Single-Vessel
Hemodynamic fMRI to Perivascular & CSF Dynamic Mapping With the
14T Preclinical Scanner
Xin Yu
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14:18 |
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A Practical Guide to Multimodal Brain Imaging in Sleep & Across
Brain States
Laura Lewis
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14:42 |
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Sleep-Dependent Global Brain/Physiological Dynamics & Its
Clinical Relevance
Xiao Liu
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15:06 |
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Ultra-Fast MRI by MREG to Study the Sleeping & Diseased Brain
Vesa Kiviniemi
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