ISMRM25 - Liver & Pancreas Health

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Liver & Pancreas Health

Oral

Body

Tuesday, 13 May 2025

316B

08:15 - 10:15

Moderators: Mary-Louise Greer, Scott Reeder & Wen-Chau Wu

Session Number: O-22

No CME/CE Credit

08:15		0412. Flip-angle modulated 2D-CSE-MRI for motion-robust free-breathing liver PDFF and R2* mapping in a clinical setting View Presentation Video J. Heidenreich, R. do Vale Souza, A. Anagnostopoulos, J-P Grunz, L. Müller, J. Tang, D. Tamada, A. Pirasteh, S. Reeder, D. Hernando University Madison Wisconsin, Madison, United States Impact: The motion robustness and short acquisition time of free-breathing 2D-FAM-CSE-MRI offers significant advantages, enabling reliable quantification of liver fat and iron. This is essential for diagnosis and treatment monitoring of diffuse liver disease, and with potential to improve clinical outcomes.
08:27		0413. Evaluation of Low-Field MRI for R2* and Fat Fraction Quantification in the Concomitant Presence of Hepatic Iron Overload and Steatosis View Presentation Video U. Shrestha, M. Bolding, Z. Abramson, A. Tipirneni-Sajja University of Memphis, Memphis, United States Impact: Low-field 0.55T MRI is a viable approach to improve the measurable range of R2* and FF estimation compared to 1.5T in coexisting conditions of hepatic iron overload and steatosis.
08:39		0414. MR-derived Hepatic Fat Fraction and Stiffness in Chronic Liver Disease Patients: Comparing Different Vendors and Field Strengths View Presentation Video N. Metwalli, A. Ghanem, J. Rivera, J. Matta, K. Abd-Elmoniem, A. Hamimi, A. Gharib, R. Ouwerkerk National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institutes of Health (NIH), Bethesda, United States Impact: MRE measurement differences between both scanners were significant but small within clinically acceptable range (concordance correlation, CC>0.9). However, for PDFF and MRS on 1.5T and 3T PDFF and 1.5T PDFF, the differences were significantly large and not clinically acceptable (CC<0.9).
08:51		0415. Impact of Iron Particle Size on R2* and Fat Fraction Estimation for Accurate Assessment of Hepatic Iron Overload and Steatosis Using MRI View Presentation Video U. Shrestha, S. Brasher, Z. Abramson, C. Morin, A. Tipirneni-Sajja University of Memphis, Memphis, United States Impact: In the concomitant presence of fat and iron, the size of iron particles can affect the accuracy of fat fraction and R2* estimations, and hence may cause bias in the assessment of hepatic iron overload and steatosis using MRI.
09:03		0416. PNPLA3 Gene Polymorphisms Affect MASLD Progression Severity Assessed by MRE in a Large Cohort of Clinical Patients View Presentation Video P. Xu, S. Tian, C. Qiu, H. Wu, J. Li, E. Klee, A. Allen, R. Ehman, M. Yin Mayo Clinic, Rochester, United States Impact: Genotype impacts liver stiffness, thus understanding their association is essential for improving MASLD prevention, prognosis, and treatment. Integrating genetic risk and LS assessment could enhance risk prediction for liver complications.
09:15		0417. 31P-MRS saturation transfer to assess hepatic ATP synthesis at 3T in individuals with type-1-diabetes and control volunteers View Presentation Video M. Jonuscheit, B. Korzekwa, M. Schär, J. Mevenkamp, S. Wierichs, P. Bobrov, S. Kahl, M. Roden, V. Schrauwen-Hinderling Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany Impact: To make the ³¹P-MRS ST technique more broadly available for metabolic research, the method is established on a clinical scanner, allowing investigation of ATP synthesis in the liver with good localization and is sensitive to changes occurring with T1D.
09:27		0418. Quantification of Pancreatic Fat as a Predictor of Impaired Glucose Tolerance and Type 2 Diabetes M. Wang, X. Zhao, B. Xu, L. Li, Z. Dong Department of Radiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Impact: This study presents a non-invasive method to quantify pancreatic fat, enhancing early detection and risk prediction for impaired glucose tolerance and type 2 diabetes, and offering new insights into pancreatic fat’s role in insulin resistance and diabetes progression.
09:39		0419. Hepatic artery and portal vein selective non-contrast MR perfusion in the liver View Presentation Video Y. Kuwatsuru, V. Malis, Y. Kassai, C. Sirlin, M. Miyazaki University of California, San Diego, La Jolla, United States Impact: Current methods like dynamic contrast-enhancement require the use of contrast agents to measure arterial and portal blood flow. We propose a novel non-invasive non-contrast alternative, enabling separate assessments of HA and PV perfusion, making liver diagnostics safer and more accessible.
09:51		0420. Multiparametric 3D Vector Magnetic Resonance Elastography Reveals Hepatic Biphasic Mechanical Properties in Rat Models of Portal Hypertension View Presentation Video C. Qiu, P. xu, H. Wu, J. Li, N. Owusu, K. Glaser, U. Yaqoob, V. Shah, A. Manduca, R. Ehman, M. Yin Mayo Clinic, Rochester, United States Impact: Advanced MRE assessment of tissue mechanical properties offer novel imaging biomarkers for fluid pressure-related pathological processes. This approach promising approach for evaluating new therapeutic interventions for portal hypertension.
10:03		0421. Complete Perilesional Ring on MRI as the indicator of pathological complete response after transarterial therapy for hepatocellular carcinoma View Presentation Video M. Duan, Q. Yang, R. Zhang, Y. Yuan, J. Zhang, C. Xie Sun Yat-sen University Cancer Center, Guangzhou, China Impact: The ring classification provides a more specific pCR probability on the basis of mRECIST, guiding 46.1% nodules with 85.4% pCR possibility to Watch & Wait strategy, and 27.4% nodules with 56.1% pCR possibility to comprehensive treatment by liver surgeon.

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