ISMRM25 - X-Men: Deuterium & Other Non-Proton MR

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

X-Men: Deuterium & Other Non-Proton MR

Oral

Contrast Mechanisms

Monday, 12 May 2025

313A

08:15 - 10:15

Moderators: Wei Chen & Arvin Forghanian-Arani

Session Number: O-34

CME Credit

08:15		0036. In vivo 2H-MR spectroscopy of trimethylamine metabolism in the liver by the hepatic enzyme FMO3 H. Dessau, T. Harris, H. Allouche-Arnon, A. Bar-Shir Weizmann Institute of Science, Rehovot, Israel Impact: The ability to monitor the TMA-d9-to-TMAO-d9 metabolism will allow us to follow, for the first time longitudinally and non-invasively, the role of TMAO in the onset and progression of multiple diseases ranging from cancer to cardiovascular disease.
08:27		0037. Metabolic modeling using Deuterium Metabolic Imaging data in healthy, epileptogenic and glioblastoma brain tissue R. Buijs, N. Ahmadian, K. Tesselaar, S. Otto, M. Gosselink, H. Hoogduin, N. Van Klink, P. Van Eijsden, D. Klomp, E. Wiegers University Medical Center Utrecht, Utrecht, Netherlands Impact: This study demonstrates the potential of deuterium metabolic imaging with metabolic modeling to estimate the tricarboxylic acid cycle rate in brain tissue, providing insights into epilepsy and glioblastoma. Findings could enhance non-invasive diagnostics and individualized treatment strategies.
08:39		0038. Parallel Detection of Lactate-Edited 1H MRSI and DMI to Differentiate Total and Active Lactate Pools in Brain Tumors Y. Liu, C. Kumaragamage, T. Nixon, S. McIntyre, H. De Feyter, R. de Graaf United Imaging Healthcare North America, Houston, United States Impact: The interleaved edited ¹H MRSI and DMI offers an opportunity to study and compare the static and active metabolism in parallel with robust ¹H-Lac detection providing novel and complementary insights to the wide range of clinical MRI scans.
08:51		0039. Oral administration of 2H9-choline at human dose for deuterium metabolic imaging of brain tumors V. Osoliniec, M. Thomas, R. de Graaf, H. De Feyter Yale University, New Haven, United States Impact: Our results indicate that a lower dose of orally provided deuterated choline generated comparable tumor-to-brain contrast to IV administration, facilitating the potential clinical translation of DMI of deuterated choline.
09:03		0040. Deuterium-labeled α-ketoglutarate enables metabolic imaging of the isocitrate dehydrogenase mutation in brain tumors. C. Taglang, G. Batsios, A-M Gillespie, P. Viswanath UCSF , San Francisco, United States Impact: Our studies provide proof-of-concept evidence that diethyl-[3,3’-²H]-α-ketoglutarate informs on tumor burden and treatment response in IDHm gliomas. Clinical translation of diethyl-[3,3’-²H]-a-ketoglutarate will provide clinicians with a tool to monitor disease progression in IDHm glioma patients, which is currently challenging.
09:15		0041. High resolution 3D Deuterium Metabolic Imaging of the human brain using bSSFP with concentric ring trajectory readout at 7T S. Frese, B. Strasser, L. Hingerl, E. Montrazi, L. Frydman, V. Bader, A. Duguid, A. Osburg, S. Motyka, M. Krssak, T. Scherer, R. Lanzenberger, W. Bogner, F. Niess Medical University of Vienna, Vienna, Austria Impact: Improving SNR and consequently spatial resolution of deuterium metabolic imaging (DMI) data is crucial to push DMI towards clinical application. bSSFP-CRT sequences combined with appropriate reconstruction and metabolite separation can facilitate this transition.
09:27		0042. Deuterium metabolic imaging reveals altered glucose metabolism in a multiple sclerosis mouse model N. Vidas-Guscic, M. Heady, X. Ge, J. Garbow, C. Guglielmetti Washington University School of Medicine, Saint Louis, United States Impact: DMI can assess Glx levels non-invasively in MS and could serve as a novel marker of neuronal damage following demyelination. DMI is clinically translatable and holds potential for future MS clinical trials and other disorders presenting Glx imbalance.
09:39		0043. Respiratory motion corrected interleaved 23Na/1H pTx MRI of the human heart at 7 Tesla L. Ruck, N. Egger, C. Kopp, T. Wilferth, S. Konstandin, M. Uder, A. Nagel Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany Impact: Interleaved ²³Na/¹H pTx MRI allows to perform respiratory motion correction of the ²³Na MR data based on the additional ¹H MR data. This could enhance the accuracy of myocardial Na⁺ quantification and improve inter-subject comparability.
09:51		0044. Ionic and Microstructural Alterations in the Corticospinal Tract in SPG4: Insights from Sodium Imaging G. Venturi, E. Cantoni, M. J. Rochat, G. Vornetti, A. Quinzi, G. Rizzo, V. Vacchiano, G. Sighinolfi, F. Zaccagna, D. N. Manners, R. Lodi, C. Tonon IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy Impact: This study demonstrates the potential of sodium MRI as a non-invasive biomarker for early detection of ionic disturbances in HSP-SPG4, enabling improved monitoring of disease progression. It opens avenues for exploring targeted therapies and differentiating HSP-SPG4 from other neurodegenerative disorders.
10:03		0045. Sodium signal evolution in kidney imaging at 7T after water intake applying an interleaved sequence scheme for 23Na/1H(pTx) imaging J. Schirmer, L. Ruck, N. Egger, J. Herrler, S. Nagelstraßer, T. Wilferth, T. Platt, S. Wildenberg, A. K. Bitz, C. Kopp, M. Uder, A. M. Nagel Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany Impact: This study demonstrates the feasibility of interleaved ²³Na/¹H(pTx) MRI at 7T to assess renal sodium dynamics non-invasively, allowing exploration of hydration effects on renal sodium balance. Improved B₁-correction and respiratory motion correction could enhance early detection of kidney function changes.

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