ISMRM25 - Novel Insights in MRI Through Multi- & Micro-Contrast Advances

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Novel Insights in MRI Through Multi- & Micro-Contrast Advances

Oral

Contrast Mechanisms

Monday, 12 May 2025

313A

13:45 - 15:45

Moderators: Alex MacKay & Kwok-Shing Chan

Session Number: O-36

CME Credit

13:45		0146. Detecting Phosphorous in Myelin via Water: A Proof-of-Principle Breakthrough Towards a New Contrast Technique View Presentation Video A. Ensworth, C-A Knight, C. Laule, A. MacKay, C. Michal The University of British Columbia, Vancouver, Canada Impact: This breakthrough enables specific detection of myelin phospholipids with MRI, potentially leading to earlier diagnoses and better tracking of myelin-based conditions. It opens new avenues for research and development of more precise imaging techniques for neurological disorders.
13:57		0147. Molecular basis of diffusion MRI in human hippocampus revealed by ultrahigh resolution diffusion at 14.1 Tesla and spatial transcriptome View Presentation Video Y. Shen, P. Wang, Z. Zhao, Z. Cao, Q. Zhu, J. Zhang, D. Wu Zhejiang University, Hangzhou, China Impact: This study combined dMRI data with transcriptomic data, and revealed the molecular basis of dMRI phenotypes from a microscale perspective. This paradigm could be extended to other imaging modalities and applications in clinical disorders.
14:09		0148. Linking the cerebellar morphology with cytoarchitecture using motion-corrected, RF-shimmed, 7T MRI View Presentation Video N. Priovoulos, P. Bazin, E. Brouwer, J. Mejias, M. de Buck, A. Alkemade, W. van der Zwaag, M. Caan Wellcome Centre for Intergrative Neuroimaging, Oxford, United Kingdom Impact: The detailed human cerebellar morphology is unexplored. Here, we combine motion-corrected, RF-shimmed 7T-MRI with a novel segmentation approach to demonstrate links between in-vivo/post-mortem cerebellar morphology, vasculature and cytoarchitecture. This may provide insights into the pathology of several neurological disorders.
14:21		0149. Early detection of cell death using transmembrane water exchange MRI View Presentation Video A. Kaika, L. Nagel, B. Xie, G. Topping, M. Schillmaier, F. Heijster, J. Rauch, T. Kuder, S. Sühnel, S. Ballke, K. Steiger, P. Paprottka, J. Nadjiri, K. Brindle, W. Weber, F. Schilling Technical University of Munich, Munich, Germany Impact: Transmembrane water permeability measured by AXR is a sensitive marker for cell death during cancer progression or therapy. FEXI is a contrast agent-free technique that can be easily included in clinical MR protocols.
14:33		0150. Quantum Dipole Interactions Within Transient Hydrogen Bonds (THB) Define T1 Signal and Anisotropy in Neuronal Tissue. Theory and Validation. PDF Poster View Presentation Video D. Yablonskiy, A. Sukstanskii, J. Quirk Washington University in St. Louis, St. Louis, United States Impact: The proposed and validated Transient Hydrogen Bond (THB) model provides a novel framework linking experimental T1 relaxation measurements to the underlying structure of cellular and myelin membranes. This approach offers a new avenue for investigating the microstructure of biological tissues.
14:45		0151. Modeling lactate diffusion in gray matter in the context of the astrocyte-neuron lactate-shuttle View Presentation Video E. Mougel, J. Valette Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France Impact: Three-compartment modeling of lactate diffusion is a promising tool for assessing lactate compartmentation in gray matter. It yields lactate fraction in astrocyte, neurons and extracellular space compatible with ANLS, but its use remains difficult when noise is large.
14:57		0152. Vessel Distribution Imaging (VDI) enables the exploration of vessel size distribution within a voxel View Presentation Video S. Han, D. Lee, H. Cho Korea Basic Science Institute (KBSI), Ochang, Korea, Republic of Impact: VDI not only validate the effectiveness of the DDIF approach for assessing microvascular dynamics but also highlight its potential application in early disease diagnosis and monitoring.
15:09		0153. Brain Tissue Differentiation Using Diffusion-Relaxation Correlation Spectrum Imaging with a Spectral Weighting-Based Clustering Method View Presentation Video G. Shao, F. Sanvito, Z. Wang, W. Kim, H. Wu, B. Ellingson, D. Ruan, J. Yao University of California, Los Angeles, Los Angeles, United States Impact: The integration of DR-CSI spectra with spectral weighting-based clustering enables automated and precise differentiation of tissue components and sub-voxel tissue characterization. This approach shows promise in distinguishing challenging tumor types, potentially transforming brain tumor diagnostics and treatment planning.
15:21		0154. Water excitation may induce signal asymmetries in the bSSFP profile which affects parametric mapping View Presentation Video G. Cheng, B. Acikgoz, N. Plaehn, J. Bastiaansen Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland Impact: Using advanced water excitation pulses enabled fat-free multiparametric mapping with phase-cycled bSSFP. This benefits relaxometry that may be confounded by fat, which is particularly interesting for quantitative imaging in pathologies such as metabolic dysfunction-associated steatotic liver disease, where fat accumulates.
15:33		0155. Effect of extracellular space preservation and partial delipidation on ex vivo brain MRI tissue contrast and microstructure View Presentation Video J. Yao, H. Lee, K-S Chan, X. Lu, W. Wang, Z. Wu, J. Ackerman, H-H Lee, S. Huang Massachusetts General Hospital, Charlestown, United States Impact: Incorporating advanced tissue preparation methods in ex vivo MRI studies will improve accuracy of histopathologic correlations and translational relevance to in vivo imaging interpretation.

Similar Session(s)