Oral
Hyperpolarization
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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0293. Median-anchored
Generalized Linear Binning vs Conventional Methods to Quantify
129Xe Lung Ventilation MRI
R. Hussain, J. Plummer, A. Bdaiwi, M. Willmering, L. Walkup,
Z. Cleveland
Cincinnati Children's Hospital Medical Center, Cincinnati, United States
Impact: Median-anchored generalized linear binning
analysis of HP-129Xe
ventilation images enabled improved detection of subtle
ventilation impairments in people with cystic fibrosis. This
method shows promise for broader applications across
obstructive diseases, advancing early diagnosis and disease
monitoring.
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| 16:12 |
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0294. Mapping
the Chemical Shift of 129Xe in Red Blood Cells as a Biomarker
for Pulmonary Hypertension
A. Costelle, S. Leewiwatwong, J. Mugler III, S. Rajagopal,
D. Mummy, B. Driehuys
Duke University, Durham, United States
Impact: This work offers a proof-of-concept that mapping
the 129Xe
RBC chemical shift could be valuable in assessing PH.
Compared to current gold standard diagnostic techniques, 129Xe
CSI is less invasive and, with further optimization, may
permit localization of vascular occlusion.
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| 16:24 |
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0295. A
Comparison of the 1-Point Dixon, Multiple Echo IDEAL, and
Chemical Shift Imaging methods for Hyperpolarized 129Xe
Spectroscopic Imaging
R. Meyer, M. McIntosh, K. Staab, J. Percy, O. Aboderin, S.
Khodaei, A. Kizhakke Puliyakote, R. Schulte, C. Wharff, S.
Fain, A. Hahn
University of Iowa, Iowa City, United States
Impact: These results on a small cohort of participants
provide preliminary support for equivalence between 1-Point
Dixon, ME IDEAL, and CSI methods in the same healthy
participant. This work shows promise for the standardization
of hyperpolarized 129Xe
gas-exchange imaging measures.
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| 16:36 |
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0296. Evaluating
the acute response to oxygen using hyperpolarized 129-xenon
dissolved-phase MRSI interleaved with global MRS in a porcine
model
M. Vaeggemose, M. Andersen, M. Kristensen, E. Hansen, C.
Laustsen, R. Schulte
Aarhus University, Aarhus, Denmark
Impact:
The study implements and validates a dissolved-phase MRSI with interleaved MRS to image gas transfer and RBC oscillations during vasoactive interventions. Alveolar-capillary modulation effects on blood oscillations are crucial for the methods application in detection of pulmonary arterial hypertension detection. |
| 16:48 |
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0297. Assessment
of differential activation of TCA cycle activity and PDH flux by
DCA in skeletal muscle using hyperpolarized
[2-13C,3-2H3]pyruvate
S-H Lin, M. Huynh, Z. Erfani, S. N. G. Wathukara Dewage,
B. Kucejova, T. Jue, Z. Kovacs, S. Burgess, J. M. Park
UT Southwestern Medical Center, Dallas, United States
Impact: The dichloroacetate-induced PDH activation was
detected with a smaller activation of glutamate, suggesting
that the TCA cycle activity was not proportional to the PDH
flux in the skeletal muscle. This highlights that ALCAR may
play a significant role.
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| 17:00 |
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0298. Measuring
extracellular pH in 3D using an iterative least squares
frequency decomposition and hyperpolarized 13C-labelled Z-OMPD
J. Gaubatz, A. Wendlinger, N. Setzer, F. Gaksch, M. Grashei,
F. Schilling
TUM School of Medicine and Health, Department of Nuclear Medicine, TUM University Hospital, Munich, Germany
Impact: The proposed iterative least squares frequency
decomposition method enables fast 3D pH measurement using
hyperpolarized [1,5-13C2]Z-OMPD,
providing an alternative to the previously used 2D
spectroscopic sequences. The acquisition of 3D pH maps
enhances the ability to investigate tumor acidification.
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| 17:12 |
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0299. Hyperpolarized
[13C]Bicarbonate Selective CINE: Correlation of Myocardial
Metabolism with Rate-Pressure Product During Cardiac Stress
M. Redda, N. Bøgh, E. Hansen, U. Kjærgaard, R. Schulte, C.
Laustsen
Aarhus University, Aarhus, Denmark
Impact: BicarbCINE provides high temporal resolution and
specificity in cardiac metabolic imaging, significantly
advancing the assessment of myocardial metabolism. This
technique could enhance diagnostic accuracy for cardiac
diseases, improve patient management, and guide treatment
decisions, especially in stress-induced cardiac dysfunction.
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| 17:24 |
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0300. Dynamic
Hyperpolarized MRI for Imaging ¹³C-Ketoisocaproate Metabolism in
an Alzheimer’s Disease model
I. Skre, D. Christensen, A. Fredriksen, M. Karlsson, R.
Olin, M. Lerche
Technical University of Denmark (DTU), Kongens Lyngby, Denmark
Impact: We introduce a dynamic method to measure BCAT
activity in vivo,
with initial results indicating increased activity in a
preclinical Alzheimer's model. By enabling real-time
tracking of KIC metabolism, we provide a tool for
investigating metabolic alterations in neurological
disorders.
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| 17:36 |
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0301. Visualization
of long-lasting metabolic change in the brain of
pseud-infectious model mice using hyperpolarized 13C MRI with
PHIP-SAH.
M. Yamasaki, H. Tomiyama, H. Hirata, S. Matsumoto
Information Science and Technology, Hokkaido University, Sapporo, Japan
Impact: Brain metabolic alterations measured by
hyperpolarized 13C pyruvate MRI
may reflect neurological dysfunction associated with
serotonin abnormalities, suggesting its potential as a
diagnostic tool for identifying brain impairments linked to
RNA virus infections and related neuropsychiatric
conditions.
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| 17:48 |
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0302. Imaging
Brain Perfusion Using Time-encoded PCASL and Hyperpolarized
[13C,15N2]Urea MRI in Healthy Volunteers
P. Joshi, D. Shin, R. Bok, D. Vigneron, J. Gordon, Y. Kim
University of California, San Francisco, San Francisco, United States
Impact: The
combined hyperpolarized [13C,15N2]urea
and ASL MRI can provide a multifaceted assessment of brain
arterial flow, venous drainage, and tissue perfusion that
may enhance diagnostic capabilities and evaluation in
clinical settings.
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