Oral
Mapping Tissue Stiffness: Emerging Frontiers in MRI Elastography
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
Oral
Mapping Tissue Stiffness: Emerging Frontiers in MRI Elastography
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0790. Simultaneous
Tamper-less MR Elastography and Diffusion Tensor Imaging of the
Human Brain
K. N. Magdoom, J. Sarlls, A. Avram, P. Basser
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States
Impact: This study could facilitate the use of intrinsic
brain tissue motion induced by cardiac pulsations to
diagnose subtle neurological diseases.
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| 08:27 |
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0791. MR
Elastography Reveals Lower Hippocampal Stiffness in Middle-Aged
APOE ε4 Carriers Without Cognitive Impairment
L. Hiscox, B. Karat, L. Wood, R. Davis, A. Corbett, C.
Metzler-Baddeley, C. Johnson, D. Jones
Cardiff University, Cardiff, United Kingdom
Impact: MR elastography is a valuable tool for studying
at-risk populations. Future research should determine if
preclinical changes in tissue mechanics influence
Alzheimer’s disease pathogenesis. Findings also have broader
implications for precision medicine and risk stratification
in dementia research.
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| 08:39 |
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0792. Tissue
remodeling after ischemic stroke influences brain biomechanics
and can be captured with MR Elastography
R. Zierold, R. Zerelles, P. Kilic, M. Harlacher, N.
Heselmaier, T. Poth, A. Barbier, M. Fischer, G. Annio, S.
Amin, V. Sturm, S. Heiland, M. Bendszus, R. Sinkus, H.
Marti, R. Kunze, K. Schregel
University Hospital Heidelberg, Heidelberg, Germany
Impact: MR Elastography reveals dynamic biomechanical
changes of infarcted and normal appearing brain tissue
following transient ischemia. Thus, MRE can support the
characterization of post-ischemic tissue reorganization,
providing information occult to clinically established
imaging techniques.
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| 08:51 |
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0793. Fat-Water
MR Elastography with Distributed Encoding for Accelerated
Imaging of Brain and Skull Displacement
A. Diano, A. Cerjanic, O. Bailey, M. Kramer, J.
Mojumder, D. Pham, C. Johnson
University of Delaware, Newark, United States
Impact: Quantifying relative skull-brain motion with the
proposed sequence will help researchers define the transfer
of skull-to-brain force transmission for ultimately
determining regional variation in tissue displacement
throughout the brain and the influence of different
directions and frequencies of applied motion.
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| 09:03 |
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0794. Free
Running Asynchronous Magnetic Resonance Elastography
P. Rossman, R. Grimm, R. Ehman
Mayo Clinic, Rochester, United States
Impact: Currently external vibration hardware used in
MRE requires a physical connection to the MRI system.
Removing this requirement would simplify and facilitate the
deployment of MRE on some lower cost MRI systems,
contributing to wider adoption.
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| 09:15 |
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0795. Repeatability
of an MR elastography biomarker for quantitatively assessing
myofascial interface mobility in chronic lower back pain
E. Hojo, Y. Sui, X. Shan, K. Zheng, P. Rossman, T. Waters,
A. Manduca, G. Powell, K-N An, K. Zhao, B. Bauer, R. Ehman,
Z. Yin
Mayo Clinic College of Medicine, Rochester, United States
Impact: The study demonstrated a non-invasive imaging
technique for quantifying myofascial mobility in the lower
back, with promising repeatability metrics suggesting SII
could serve as a reliable biomarker for assessing myofascial
adhesion in MPS patients with chronic low back pain.
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| 09:27 |
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0796. Mechanically
anisotropic phantoms for magnetic resonance elastography
K. Eckstein, D. Yoon, M. Ruding, R. Balouchzadeh, A.
Thompson-Mazzeo, R. Okamoto, C. Johnson, M. McGarry, P.
Bayly
Washington University in St. Louis, Saint Louis, United States
Impact: The accurate detection of mechanical anisotropy
within our phantom builds the credibility of anisotropic MRE
techniques, which could have future clinical use to detect
pathological changes to fibrous tissues like brain white
matter.
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| 09:39 |
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0797. 3D
MR Elastography-Based Stiffness for Assessment of Expression
Level of Piezo1 Protein in Hepatocellular Carcinoma
S. Ouyang, J. Zhou, Y. Zeng, Y. Wang, Z. Fang, J. Chen, M.
Yin, K. Glaser, R. Ehman, J. Wang
The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
Impact: MRE-based tumor stiffness may be promising for
noninvasively predicting Piezo1 protein expression in HCC
patients. It provides valuable quantitative biomarker for
assessing tumor aggressiveness in HCC.
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| 09:51 |
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0798. Implementing
Magnetic Resonance Elastography in the MAGNUS for Evaluation of
High-Performance Gradient Coil Effects
H. Morris, E. Long, C. Wisdom, G. Klarmann, D. Pham, V. Ho
Uniformed Services University, Bethesda, United States
Impact: This study clarifies the advantages and
limitations of high-performance gradient systems for brain
MRE, guiding protocol optimization, inversion and signal
processing methods, and acquisition techniques while
furthering our understanding of applications best suited for
high-performance gradients.
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| 10:03 |
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0799. Feasibility
of Liver MR Elastography at 0.55 T
M. Ohliger, C. Hong, K. Pepin, K. Wang, W. Majeed, P. Su, S.
Kannengiesser, J. Heilman, R. Ehman, Y. Yang
University of California, San Francisco, San Francisco, United States
Impact: High-quality MRE acquisitions have been shown to
be possible at 0.55T. MRE at lower fields and larger bore
size is feasible, which will help make this technology
accessible to a larger range of patients who need it.
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