ISMRM25 - Diffusion: Microstructure

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Diffusion: Microstructure

Oral

Diffusion

Monday, 12 May 2025

323AB

13:45 - 15:45

Moderators: Elda Fischi-Gomez & Lipeng Ning

Session Number: O-40

No CME/CE Credit

13:45		0126. DR-CSI for In Vivo Tumor Heterogeneity and Lymph Node Metastasis Prediction in Oral Tongue Squamous Cell Carcinoma Y. Dai, S. Li, W. Hu, D. Wu, P. Hu, Y. Wu ShanghaiTech University, Shanghai, China Impact: DR-CSI enables detailed in vivo mapping of tumor microstructure in OTSCC, facilitating precise lymph node metastasis prediction and offering a powerful tool for non-invasive risk stratification. Its use could improve staging accuracy and optimize treatment planning for OTSCC.
13:57		0127. Experimental investigation of a simple estimate of axon size View Presentation Video H. Alderson, M. Does, K. Harkins Vanderbilt, Nashville, United States Impact: Diffusion time difference in radial diffusivity is shown in this work to correlate well with histology derived axon diameter. Importantly, it is straightforward to measure and therefore provides a simple estimate of axon diameter.
14:09		0128. Combination of MR Cell Size Imaging and Magnetization Transfer Imaging to Predict Intestinal Disease Progression in Crohn’s Disease X. Wang, L. Huang, R. Mao, Z-w Zhang, X. Shen, Q. Zheng, R. Zhang, Y. Wang, L. Wu, Y. Ke, C. Zhao, M. Wang, Z. li, Z. Peng, C. h. Sun, S-t Feng, X. Li The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Impact: TD-dMRI-derived d effectively characterizes fibrosis-associated cellular microstructures in patients with CD, and combined with normalized MT ratio enables a comprehensive assessment of intestinal fibrosis and thus accurate prediction of disease progression.
14:21		0129. Reducing the NEXI acquisition time for the quantification of human gray matter microstructure on the CONNECTOM 2.0 scanner View Presentation Video Q. Uhl, T. Pavan, J. Gerold, K-S Chan, Y. Jun, A. Bhatt, Y. Ma, H-H Lee, S. Huang, B. Bilgic, I. Jelescu CHUV, Lausanne, Switzerland Impact: We demonstrate an effective method for reducing Neurite Exchange Imaging acquisition time on the CONNECTOM 2.0 scanner. This approach has potential for broader application on clinical scanners in routine neuroimaging, facilitating gray matter microstructure insights in patient populations.
14:33		0130. Disentangling microscopic anisotropy and diffusion time dependence in the brain using oscillating gradients with spherical b-tensor encoding PDF Poster View Presentation Video M. Aggarwal, L. Jantzie Johns Hopkins University School of Medicine, Baltimore, United States Impact: We demonstrate that oscillating spherical and linear b-tensor encoding waveforms allow mapping of frequency-dependent isotropic diffusivity, diffusional variances, and μFA in the brain. The results are important to understand the effects of spectral content of the waveforms in tensor-valued dMRI.
14:45		0131. Inversion Recovery-Prepared Q-Space Trajectory Imaging of the Human Brain View Presentation Video O. Goedicke, J. Yu, F. B. Laun, M. E. Ladd, T. A. Kuder German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany Impact: Partial volume effects substantially impact the value distribution of QTI-derived microparameters in the human brain. Inversion recovery preparation could improve the accuracy and interpretability of such parameters. IR-QTI may therefore advance the microstructural characterization of healthy and diseased tissue.
14:57		0132. Virtual histology of Alzheimer’s disease pathology in the ex vivo human brain using diffusion-T2 relaxation correlation multidimensional MRI View Presentation Video E. Manninen, C. Comrie, E. Hutchinson, G. Serrano, D. Benjamini National Institute on Aging, Baltimore, United States Impact: Ex vivo diffusion-T₂ relaxation correlation MRI can be used to detect multiple Alzheimer’s disease pathologies. This approach could lead the way for advanced in vivo characterization of pathologies related to aging and dementia.
15:09		0133. SANDI-Based Analysis of White Matter Hyperintensity Penumbras in Post-Stroke Patients at 5.0T MRI View Presentation Video Y. Li, H. Zhang, L. Wang, S. Xu, H. Wang, H. Li Institute of Science and Technology for Brain-inspired Intelligence,Fudan University, Shanghai, China Impact: This study demonstrates SANDI’s capability on 5T MRI for detecting white matter hyperintensity penumbras in post-stroke patients, offering a promising biomarker for early white matter damage and advancing clinical stroke assessments through microstructural insights.
15:21		0134. MR hydrophysiology reveals multiple exchange pathways in neural tissue View Presentation Video N. Williamson, R. Ravin, T. Cai, J. Rey, P. Basser Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, United States Impact: A multisite exchange mechanism involving passive transmembrane and geometric pathways can explain connections to activity. Most of the transmembrane water exchange occurs through lipid bilayers in gray matter. This knowledge should inform the development of novel quantitative MRI biomarkers.
15:33		0135. Revealing membrane integrity in human brain using oscillating-gradient diffusion sequence in two frequency-varying regimes PDF Poster View Presentation Video D. Sung, W. Zhong, J. Zheng, Q. Tian, S. Huang, H-H Lee Massachusetts General Hospital and Harvard Medical School, Charlestown, United States Impact: We measured frequency-dependent kurtosis in human brains using oscillating-gradient-spin-echo sequence with either a fixed number of oscillations or a fixed total waveform time. The observed kurtosis frequency-dependence in two approaches were orthogonal, providing a novel way to evaluate water exchange.

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