ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Oral

Mesoscale fMRI

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Mesoscale fMRI
Oral
fMRI
Thursday, 15 May 2025
313A
13:15 -  15:15
Moderators: SoHyun Han & Benedikt Poser
Session Number: O-46
CME Credit
13:15   Introduction
Benedikt Poser
13:27 1254. Depth-dependent dynamics of negative BOLD response in the human primary visual cortex
N. J. Fesharaki, A. Vinogradov, J. Kim
UTHealth Houston, Houston, United States
Impact: This study demonstrated a linear increase in NBR from deep to superficial gray matter, paralleling the depth trend of PBR, and revealed distinct nHRF types with consistent depth trends across both contralateral and ipsilateral side.
13:39 1255. Delayed layer-specific CBV fMRI response is driven by somatostatin neuron-astrocyte-vasodilation pathway
T. Vo, W. Jung, T. Jin, G. H. Im, S. Lee, S-G Kim
Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon 16419, Rep, Suwon, Korea, Republic of
Impact: Our findings have significant implications for the neurovascular coupling field by revealing a novel contribution of interneurons and astrocytes. They also offer important insights for human fMRI, the interpretation of laminar-specific fMRI data and the design of laminar-specific fMRI paradigms.
13:51 1256. Developmental differences in haemodynamics drives temporal features of the cortical-depth-dependent BOLD response in neonates at 7T
J. Willers Moore, E. Pickles, P. Bridgen, P. Di Cio, L. Billimoria, I. Tomazinho, C. Da Costa, D. Gallo, G. Hartung, A. D. Edwards, J. Hajnal, S. Malik, K. Uludag, J. Polimeni, T. Arichi
King's College London, London, United Kingdom
Impact: Developmental differences in haemodynamics and cerebral physiology significantly alter temporal and amplitude features of the cortical-depth-dependent BOLD response in neonates. This has clear implications for using fMRI to study the emergence of brain activity across this critical period.
14:03 1257. Ultra-high resolution Functional and Anatomical imaging in humans at 10.5T .
L. Vizioli, S. Moeller, L. Dowdle, K. Ugurbil, E. Yacoub
CMRR, University of Minnesota, Minneapolis, United States
Impact: Imaging with the highest spatial resolution at 10.5T, while moving towards the 0.01µL voxel volume goal (Brain Initiative 2.0), reduces single voxels to a few thousand neurons, heralding new avenues in human neuroscience with fMRI
14:15 1258. Development of GRASE Pulse Sequence with larger field of view for Mesoscale functional MRI on the Next Generation (NexGen) 7T scanner
A. Beckett, S. Park, S. Häkkinen, E. Walker, A. Vu, D. Feinberg
University of California, Berkeley, Berkeley, United States
Impact: The advanced hardware of the NexGen 7T combined with accelerated 3D GRASE incorporating random sampling allows for increases in coverage and resolution to enable mesoscale imaging. GRASE images show decreased pial vein and brain surface layer bias than GE-EPI
14:27 1259. Blood-nulling versus tissue-suppression: Enhancing integrated VASO and perfusion (VAPER) contrast for laminar fMRI
Y. Chai, L. Li, R. Stirnberg, L. Huber, T. Stöcker, P. Bandettini, B. Sutton
UIUC, Urbana, United States
Impact: We proposed an innovative MT-enhanced VAPER imaging sequence for layer fMRI that enhances sensitivity by 30% compared to traditional VAPER without MT, while maintaining superior laminar specificity without increasing acquisition time.
14:39 1260. Magnetization-Transfer 2D Echo Planar Imaging for 7T Laminar fMRI
B. Qin, X. Ma, Y. Chai, J. Qu, J-H Gao
Center for MRI Research, Peking University, Beijing, China
Impact:

The MT-EPI method enhances the spatial specificity in laminar fMRI. It is time-efficient and allows flexible adjustment of MT parameters to optimize the sequence under SAR constraints.
14:51 1261. Mesoscale fMRI at ultra-high spatiotemporal resolutions using 3D Echo Planar TIme- and DYnamic-resolved Imaging (TIDY)
Z. Dong, D. Haenelt, S. Nasr, B. Rosen, L. Wald, J. Polimeni, F. Wang
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, United States
Impact: We introduce a novel acquisition/reconstruction technique, named 3D echo planar TIme- and Dynamic-resolved imaging (TIDY), to achieve distortion-free mesoscale fMRI at ultra-high spatiotemporal resolutions (e.g., whole-brain 500-um-iso at 885-ms volume-TR; partial-brain 340-um-iso at 1.2-s volume-TR). 
15:03 1262. Advanced Echo-planar Parallel Imaging with Gradient Harmonization (AEPIG): an optimization strategy for fast high resolution fMRI
R. Huber, M. Koehler, R. Stirnberg, J. Evans, L. Knudsen, A. T. Morgan, D. Feinberg, D. Handwerker, M. Rubin, B. Akin, S. Swegle, P. Bandettini
NIH, Bethesda, United States
Impact: The proposed optimization approach AEPIG (Advanced Echo-planar Parallel Imaging with Gradient Harmonization) allows layer-fMRI protocols with GRAPPA acceleration factors up to R=20. This enabled researchers to perform whole brain layer-fMRI while maintaining common TRs (<3s). 
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