ISMRM25 - Biomarkers in Musculoskeletal Disease

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Biomarkers in Musculoskeletal Disease

Oral

Musculoskeletal

Tuesday, 13 May 2025

316C

13:30 - 15:30

Moderators: Rupsa Bhattacharjee & Jung-Ah Choi

Session Number: O-51

No CME/CE Credit

13:30		0557. Multi-Scanner harmonized 8-year longitudinal hip cartilage T1ρ and T2 View Presentation Video Y. Qian, R. Thahakoya, R. Bhattacharjee, M. Han, Z. Zhu, Y. Yang, V. Pedoia, R. Souza, S. Majumdar University of California San Francisco, San Francisco, United States Impact: The harmonized longitudinal T1ρ and T2 data provides insights into hip cartilage degeneration, aiding in understanding osteoarthritis progression.
13:42		0558. Multi-component 3D-T1ρ Mapping of Early Knee Osteoarthritis View Presentation Video H. Lise de Moura, A. Monga, D. Singh, M. Zibetti, J. Samuels, R. Regatte NYU Grossman School of Medicine, New York, United States Impact: The study shows that combining multi-component MRI parameters into a single composite biomarker can enhance diagnostic performance and outperform mono-exponential T1ρ analysis. Our proposed approach has broader potential for improving early OA detection and assessment of other diseases.
13:54		0559. Patellar Cartilage Evolution is Linked to Intra-Limb Baseline Hip Femoral Cartilage: Longitudinal Compositional Multi-Joint Study View Presentation Video R. Bhattacharjee, R. Thahakoya, Y. Qian, M. Han, F. Jiang, R. Souza, V. Pedoia, S. Majumdar University of California, San Francisco (UCSF), San Francisco, United States Impact: Relationship between longitudinal changes in patellar T1p and baseline T1p of intra-limb hip-femoral load-bearing cartilage, might be useful for the prevention of polyarticular OA development and lead to a better understanding of the propagation of OA from hip to knee.
14:06		0560. Simultaneous Bilateral T1, T2, and T1ρ Relaxation Mapping of Hip Osteoarthritis with 3D-MRI Fingerprinting View Presentation Video A. Monga, H. Moura, M. Zibetti, T. Youm, J. Samuels, R. Regatte NYU Grossman School of Medicine, New York, United States Impact: Our preliminary study demonstrates that T1, T2, and T1ρ values from 3D-MRF can potentially be used to detect early OA in the hip joint.
14:18		0561. Longitudinal Changes to Patellar Cartilage UTE-T2* After Anterior Cruciate Ligament Reconstruction Associate with Improved Knee Pain View Presentation Video A. Williams, C. Chu Stanford University, Redwood City, United States Impact: UTE-T2* qMRI evaluation shows that longitudinal changes to deep knee cartilage composition associate with concurrent clinically meaningful improvements in patient reported knee pain following ACL reconstruction.
14:30		0562. Assessment of lower limb lesions in diabetic patients utilizing BOLD-MRI at 7T: a feasibility study H. Pang, X. Zhang, J. Chen, Z. Zhen, S. Zhou, W. Chen, W. Chen 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, China Impact: BOLD-MRI could enhance the precision in assessing lower limb perfusion in diabetes, thereby aiding accurate classification and diagnosis at early stages while overcoming current diagnostic limitations through non-invasive quantitative analysis of peripheral lesions associated with diabetes.
14:42		0563. Multi-parametric quantitative MRI of the lower limb muscles in a longitudinal study of limb-girdle muscular dystrophy R9 PDF Poster View Presentation Video S. Rauh, P-Y Baudin, T. Stojkovic, S. Birnbaum, V. Decostre, R-L Zanfongnon, Y. Fromes, M. Hooijmans, G. Strijkers, J-Y Hogrel, S. Olivier, B. Marty, H. Reyngoudt Institute of Myology, Paris, France Impact: QMRI parameters in LGMD-R9 patients were significantly different from controls, with water-T2 and water-T1 correlating with the increase in FF. These findings may be valuable for identifying biomarkers in clinical trials or selecting eligible LGMD-R9 patients for therapeutic treatment studies.
14:54		0564. Reduced muscular carnosine levels in patients with Proximal Myotonic Myopathy (PROMM) - an 1H-MR spectroscopy study View Presentation Video A. Gussew, A. Deistung, M. Rothe, D. Stoevesandt, W. Wohlgemuth, A. Kölsch, M. Heuschen, A. Mensch University Hospital Halle, Halle (Saale), Germany Impact: This study demonstrates¹H-MR spectroscopy’s potential for non-invasive monitoring of PROMM-related metabolic changes by tracking carnosine concentration declines in skeletal muscle. This approach allows early detection of atrophy, supporting personalized disease management and guiding therapeutic interventions.
15:06		0565. CEST Z-spectra fitting via Bloch-McConnell equations for pH mapping: in vitro validation and application in healthy and pathological leg muscles View Presentation Video V. Henriet, P-Y Baudin, C. Slioussarenko, B. Marty, M. Lapert, H. Reyngoudt Institute of Myology, Paris, France Impact: This work advances high-resolution pH mapping for neuromuscular disease assessment, offering non-invasive insights into muscle homeostasis. By enhancing sensitivity and spatial resolution in pH measurement, it could improve the monitoring of muscle disorders, benefiting clinical research.
15:18		0566. Monitoring glycogen levels and treatment effect in a mouse model of Pompe disease View Presentation Video Q. Zeng, Y. Li, D. Timm, T. Johnson, N. Mehta, B. Fox, P. van Zijl, N. Yadav Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States Impact: Monitoring of glycogen levels is essential for assessing Pompe disease load and treatment efficacy. GlycoNOE MRI offers the possibility to non-invasively map glycogen levels in tissue using standard MRI scanners.

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