ISMRM25 - Functional Connectivity in Psychiatric Disease

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Functional Connectivity in Psychiatric Disease

Oral

Neuro

Tuesday, 13 May 2025

310 (Lili-u Theater)

13:30 - 15:30

Moderators: Lijing Xin & Yunhong Shu

Session Number: O-55

No CME/CE Credit

13:30		Introduction Ligin Xin
13:42		0499. Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression PDF Poster View Presentation Video X. Sun, G. Chen, P. Chen, X. Bu, Z. Qi, S. Zhang, C. Chen, Z. Guo, X. Tang, R. Chen, X. Wang, D. Wei, Y. Chen, B. Liu, C-C Huang, Y. Zheng, Y. Wu, T. Chen, Y. Cheng, X. Xu, Q. Gong, T. Si, S. Qiu, C-P Lin, J. Cheng, Y. Tang, F. Wang, J. Qiu, P. Xie, L. Li, Y. He, Q. Tao, M. Xia, Y. Wang Beijing Normal University, Beijing, China Impact: The findings provide valuable insights into the understanding of heterogeneous clinical forms of StD and offer promising implications for future precise diagnosis and treatment of this condition.
13:54		0500. Functional Connectivity Subtypes in Major Depressive Disorder: Insights Into Connection Patterns and Neurobiological Mechanisms View Presentation Video H. Li, Q. Li, F. Long, Y. Chen, Y. Wang, B. Yang, Q. Gong, F. Li Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China Impact: The present study suggested the presence of two distinct FC-based subtypes in MDD characterized by shared and different epicenters and biological basis, and enhanced the understanding of MDD heterogeneity.
14:06		0501. Revealing Dynamic Brain Networks in ADHD using Hyperband Resting-State fMRI View Presentation Video R. J. Ombid, P. Condron, G. Newburn, A. Wang, H. Jahanian, K. Waldie, S. Holdsworth, J. Fernandez University of Auckland, Auckland, New Zealand Impact: Hyperband fMRI with shorter TR demonstrated significant differences in dFC in ADHD. ADHD participants exhibited prolonged engagement, compared with NT, in integrated brain states across two brain atlases, demonstrating efficacy in detecting dynamic neural alterations.
14:18		0502. Disruption of the gut microbiota-inflammation-brain axis in unmedicated bipolar disorder II depression Z. Guo, W. Cui, Y. Wang First Affiliated Hospital of Jinan University, Guangzhou, China Impact: The findings bridged a gap in the underlying pathophysiological mechanism of the gut microbiota-inflammation-brain axis in BD II depression.
14:30		0503. Acute ketamine connectivity changes in patients with major depression View Presentation Video J. Evans, C. Zarate NIH, Bethesda, United States Impact: This approach could be used to evaluate the effects of novel therapeutics in the brain.
14:42		0504. Distance-Dependent Functional Dysconnectivity and Neurotransmitter Correlates in Major Depressive Disorder View Presentation Video R. Qian, H. Gao, B. Qiu, B. Gu, Z. Li, D. Wu, Z. Zhao Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Hangzhou, China Impact: Functional dysconnectivity in MDD subtypes shows distinct distance-dependent patterns and specific correlations with neurotransmitter systems. These findings advance our understanding of subtype-specific pathophysiology and may guide the development of more precise therapeutic strategies for MDD.
14:54		0505. Replication of biological subgroups using resting-state functional connectivity normative modeling in patients with PSD View Presentation Video R. Thukral, J. Maximo, A. Lahti, C. de la Fuente Sandoval, L. F. Rivera Chavez, S. Rutherford, A. Marquand, J. Larson, J. Lee, N. Kraguljac The University of Alabama at Birmingham, Birmingham, United States Impact: Biological subgroupings using normative modeling is a promising and robust method to define patient subgroups at a biological, rather than clinical, level.
15:06		0506. Feasibility of personalized rTMS targeting using rs-fMRI on a 0.5T head-only MRI scanner: initial assessment of target reproducibility View Presentation Video S. Chavez, C. Harris, J. Stainsby Synaptive Medical, Toronto, Canada Impact: This work may enable greater access to MRI-based personalized treatment planning for rTMS treatment of depression. We show that the required information is reliably obtained on a mid-field, head-only scanner which could be placed close to rTMS treatment sites.
15:18		0507. Severe Brain Network Hierarchy Disorganization in Treatment-Naïve Deficit vs. Non-Deficit Schizophrenia and Neurotransmitter Associations View Presentation Video C. Yang, L. Yao, H. Liang, S. Lui West China Hospital of Sichuan University, Chengdu, China Impact: This study found that DS showed more severe cortical hierarchy compression linked to serotonergic dysfunction, while NDS was primarily associated with dopaminergic abnormalities, highlighting distinct neurochemical pathways in each subtype.

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