ISMRM25 - Clinical Neuroimaging in Alzheimer’s Disease: Current Trends & Future Directions

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Clinical Neuroimaging in Alzheimer’s Disease: Current Trends & Future Directions

Oral

Neuro

Monday, 12 May 2025

320

13:45 - 15:45

Moderators: Yuhei Takado & Liangdong Zhou

Session Number: O-57

No CME/CE Credit

13:45		0185. Modeling structural and functional connectomics with cognitive deficits and spatial transcriptomics in a mouse model of tauopathy View Presentation Video E. Hipskind, L. Fadel, S. Pedersen, C. Ortiz, J. Romero, S. Fox, T. Manirambona, M. A. H. Samee, R. Pautler Baylor College of Medicine, Houston, United States Impact: We use machine learning to understand the relationships between structural and functional connectivity with cognitive deficits in a mouse model of tauopathy, as well as identify underlying spatial transcriptomic changes to enhance our understanding of the progression of tau pathology.
13:57		0186. Impaired cerebrovascular reactivity is associated with vascular smooth muscle cell loss in a mouse model of Alzheimer’s disease View Presentation Video X. Yang, M. Yao, Y. Li, H. Lu, W. Duan, Z. Wei The Johns Hopkins University School of Medicine, Baltimore, United States Impact: Impaired cerebral vascular reactivity (CVR) is associated with the loss of vascular smooth muscle cells in the hippocampus of 5xFAD model at 9 months of age.
14:09		0187. CEST Imaging Combined with 1H-MRS Reveal the Neuroprotective Effects of Riluzole by Improving Neurotransmitter Imbalances in 3xTg AD Mice View Presentation Video Y. Shen, S. Liu, X. Zhang, W. Xuan, C. Zhuang, Y. Chen, B. Chen, X. Zheng, Y. Lin Second Affiliated Hospital of Shantou University Medical College, Shantou, China Impact: This study highlights the potential of combining CEST imaging and 1H-MRS as a non-invasive approach to evaluate riluzole’s effects on Glu/GABA metabolism and cognitive function in AD mice, providing a promising neuroimaging tool for assessing AD therapies.
14:21		0188. Multimodal Postmortem MRI and Histopathological Analysis Reveal Complex Signal Origins of White Matter Hyperintensity in Alzheimer's Disease View Presentation Video C. Li, D. Leitner, H. Pang, M. Bruno, A. Faustin, T. Wisniewski, H. Scholtzova, Y. Wadghiri, J. Zhang, Y. Ge New York University Grossman School of Medicine, New York, United States Impact: Direct comparisons between multimodal MRI and histopathological findings revealed the complex pathological underpinnings of WMHs in Alzheimer's Disease. These insights advance our understanding of MRI signal changes with WMHs development and progression in vivo.
14:33		0189. Volumetric Histology via High-Fidelity Coregistration with MRI View Presentation Video Y. Wang, W. Ho, I. Huszar, H. Moein Taghavi, J. Nirschl, L. Tao, N. Nguyen, S. Leventis, D. Camarillo, P. Schlömer, M. Axer, W. Shao, M. Rusu, P. DiGiacomo, I. Cobos, M. Georgiadis, M. Zeineh Stanford University, Palo Alto, United States Impact: This study introduces an advanced correlative MRI-histology pipeline to reconstruct volumetric histology, promising to enhance our understanding of neurodegenerative diseases and contribute to the evolution of MRI-based disease biomarkers.
14:45		0190. Influence of microglial activation on neuronal metabolism in Alzheimer’s disease: A hybrid 3D-MRSI/PET study PDF Poster View Presentation Video Y. Zhang, J. Hu, X-H Qian, M. Zhang, Y. Zhao, Y. Li, W. Jin, C. Xu, H. Zhuang, Z. Meng, W. Li, S. Chen, X-F Jiang, Z-P Liang, B. Li, H. Tang, Y. Li Shanghai Jiao Tong University, Shanghai, China Impact: Using a hybrid 3D-MRSI/PET approach, we identified a biphasic effect of microglial activation on neuronal metabolism across healthy, prodromal AD and AD dementia stages. This approach provides a valuable tool for evaluating neuroinflammation and neuronal integrity throughout AD progression.
14:57		0191. Brain tissue electrical conductivity as a promising biomarker for dementia assessment using MRI View Presentation Video J. Chu, Z. Li, J. Li, Y. Zhang, H. He, B. Li, H. Wei Shanghai Jiao Tong University, Shanghai, China Impact: Our findings reveal a significant relationship between increased brain tissue conductivity and protein aggregation in dementia, suggesting that conductivity may be a non-invasive biomarker for monitoring AD and neurodegeneration mechanisms.
15:09		0192. DeepVBM: Implementing and Integrating Deep-Learning Models for Time-Efficient and Accurate Voxel-Based Morphology in an Open-Source Toolbox View Presentation Video P-M Sun, T-Y Huang, T-C Chuang, Y-R Lin, H-W Chung Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan Impact: Applied DeepVBM to Alzheimer’s research, it demonstrates accuracy comparable to FSL with reduced computing time. The open-source toolbox is compatible with major operating systems, accelerating neuroimaging studies and enabling more efficient, large-scale analyses.
15:21		0193. Mapping the Influence of Amyloid, Tau, and APOE Variants on White Matter Tracts in Alzheimer’s Disease View Presentation Video B. Chandio, J. Villalon-Reina, T. Nir, S. Thomopoulos, Y. Feng, S. Benavidez, N. ahanshad, J. Harezlak, E. Garyfallidis, P. Thompson University of Southern California, Marina del Rey, United States Impact: Our findings highlight the role of tau, amyloid, and APOE variants in disrupting brain connectivity, shedding light on Alzheimer's disease pathology and localized white matter tract changes.
15:33		0194. Deuterium Metabolic Imagining as an alternative to FDG-PET for the diagnosis of Alzheimer’s Disease View Presentation Video K. Trosborg, N. Christensen, N. Boegh, M. Aastrup, M. Kristensen, E. Hansen, H. Gottrup, J. Mortensen, P. Borghammer, J. Blicher, R. Schulte, J. Miller, M. Vaeggemose, C. Laustsen Aarhus University, Aarhus, Denmark Impact: This study suggests that DMI can aid the diagnosis of Alzheimer’s disease, but the low spatial resolution of DMI should be addressed in future studies. As total DMI signal correlates with FDG-PET, reducing spectral resolution could be the way forward.

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