Oral
Neurofluids & Choroid Plexus
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
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Introduction
Jun Hua
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0996. Relaxation-selective
IVIM imaging of Microvascular Perfusion and Fluid Compartments
in the Human Choroid Plexus
C. Li, Z. Sun, J. Zhang, Y. Ge
New York University Grossman School of Medicine, New York, United States
Impact: This study demonstrates a novel IVIM approach
with T1 and
T2 selection.
It can assess the ChP structure and perfusion, which can
potentially be used to evaluate age-related changes in its
fluid compartments, such as microvascular perfusion and ISF
volume.
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| 16:09 |
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0997. Linear
Fusion-Based Dual-MR Contrast Enhancement for Improved Choroid
Plexus Segmentation
K. Oh, D. Lee, I. Shin, S-M Gho
DEEPNOID, Seoul, Korea, Republic of
Impact: The proposed technique is a simple yet effective
contrast enhancement strategy for accurate choroid plexus
segmentation, which could play a crucial role in clinical
diagnostics and contribute to advancements in neuroimaging
applications for neurodegenerative diseases.
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| 16:21 |
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0998. A
Deep Learning MRI Investigation of Choroid Plexus Hypertrophy
and Alzheimer’s Disease Proteinopathy
A. Dubois, K. Hett, A. Song, M. Leguizamon, M. Curtin,
M. Garza, C. McKnight, C. Considine, M. Donahue
Vanderbilt University Medical Center, Nashville, United States
Impact: Understanding the role of the ChP in neurotoxin
clearance from the brains of healthy and AD individuals will
provide pathways for future research to target dysfunction
with disease progression, motivating clinical intervention
for efficient CSF flow and egress.
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| 16:33 |
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0999. Investigating
Choroid Plexus Subcompartments in Aging and Premanifest
Synucleinopathy Using 7 Tesla MRI
F. F. Hannanu, K. Singh, G. Garcia-Gomar, S. Grimaldi, S.
Koley, A. Stefani, A. Videnovic, M. Bianciardi
Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States
Impact: Findings reveal age-related ChP sub-compartment
volume and signal changes, with increased heterogeneity in
iRBD indicating disrupted structural integrity. ChP
sub-compartment analysis enhances understanding of ChP's
role in aging and synucleinopathies, potentially aiding
biomarker development.
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1000. Choroid
Plexus Enlargement Mediates Cognitive Decline in Traumatic Brain
Injury: UK Biobank Study
Y. Morita, K. Kamagata, M. Nakaya, K. Takabayashi, C.
Andica, J. Kikuta, T. Akashi, A. Wada, O. Abe, S. Aoki
Juntendo university, Tokyo, Japan
Impact: Our findings suggest that choroid plexus volume
could be a sensitive biomarker for TBI-related cognitive
decline. This may contribute to developing novel therapeutic
strategies targeting the choroid plexus and enable better
prediction for TBI-related cognitive dysfunction.
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1001. Investigation
of the Association Between Choroid Plexus Volume Alterations and
Cognitive Impairment in Type 2 Diabetes Mellitus
F. Zhang, Z. Cheng, Y. Wang, N. Wang, X. Zhang, P. Liang, Y.
Chen, X. Huo, B. Chen, J. Xin, M. Li, C. Liang, L. Guo
School of Medical Imaging, Binzhou Medical University , Yantai, China
Impact: This study highlights the essential role of HDL
in regulating choroid plexus volume and cognitive function,
offering new avenues for future research.
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1003. The
relationship between the choroid plexus volume and cerebral
microbleeds in the lobar locations: A large cohort study
K. Saito, K. Watanabe, S. Kasai, Y. Ishimoto, T. Shintaku,
A. Ozawa, M. Imura, T. Koshiishi, T. Mikami, Y. Tamada, S.
Kakeda
Department of Radiology, Hirosaki University School of Medicine, Hirosakicity, Japan
Impact: This study found a significant association
between lobar CMBs and CPV in a large elderly population,
including healthy individuals and those with mild cognitive
impairment (MCI), suggesting the potential clinical
relevance of lobar CMBs in MCI and asymptomatic groups.
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1004. Association
between choroid plexus features, AD pathology, and cognitive
impairment in non-demented participants: a longitudinal study
M. Lin, L. Liu, H. Hong, P. Huang
The 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Impact: Our findings provide a detailed description of
ChP structural alterations due to AD pathology, potentially
leading to cognitive impairment over time in patients with
AD.
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| 17:33 | 1002. WITHDRAWN |
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