ISMRM25 - Diffusion in AD, Dementia & Aging

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Diffusion in AD, Dementia & Aging

Oral

Neuro

Wednesday, 14 May 2025

310 (Lili-u Theater)

08:15 - 10:15

Moderators: Jennifer McNab & Trong-Kha Truong

Session Number: O-60

No CME/CE Credit

08:15		Introduction Jennifer McNab
08:27		0753. Age-Related Alterations in Tissue Microstructure along perforant pathway of Hippocampus and the Tract Template Development View Presentation Video Y. Ma, H. Lee, K-S Chan, S. Y. Huang, H-H Lee Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, United States Impact: We observed age-related alterations in tissue microstructure along the perforant pathway of hippocampus using high-gradient performance diffusion MRI. We built a hippocampal tract template using data of young subjects, offering a practical tool to investigate neurodegenerative diseases affecting hippocampal tracts.
08:39		0754. Spatiotemporal Characteristics of BBB Functional Changes in Healthy Aging: Imaging Evidence Based on Vascular Water Exchange Imaging (VEXI) View Presentation Video S. Tan, L. Chai, Z. Wang, F. Jiang, D. Shi, Y-C Hsu, X. Zhang, Y. Liu, R. Bai Zhejiang University, Hangzhou, China Impact: Our neuroimaging study reveals the BBB permeability's spatiotemporal patterns in healthy human aging, which is important for understanding the aging processes and provides with potential diagnosis biomarker for many brain diseases.
08:51		0755. The relationship between tau protein and white matter structural changes in Alzheimer's disease using fixel-based analysis View Presentation Video T. Kitagawa, K. Kamagata, W. Uchida, K. Takabayashi, C. Andica, R. Zou, T. Ozawa, A. Hagiwara, T. Akashi, K. Sano, A. Wada, S. Aoki Juntendo University Graduate School of Medicine, Tokyo, Japan Impact: Our findings suggest the possibility that neurons were degenerated through the propagation of tau along the WM and may shed light on future research on the mechanisms of cognitive decline in Alzheimer's disease.
09:03		0756. Classification of subjective cognitive decline, mild cognitive decline and Alzheimer’s’ disease using superficial white matter imaging marker View Presentation Video Y. Liu, Y. Cheng Fudan University, shanghai, China Impact: This study identifies specific SWM markers that distinguish the prodromic states of AD. By enhancing diagnostic precision for SCD, it enables targeted early interventions and opens pathways for more effective AD prevention strategies.
09:15		0757. Mapping age-related cortical laminar-specific microstructural alterations across the lifespan using high-gradient diffusion MRI View Presentation Video H. Lee, Y. Ma, K-S Chan, E. Krijnen, L. Eskandarian, A. Bhatt, J. Gerold, G. Ramos-Llordén, E. Klawiter, H-H Lee, S. Huang Massachusetts General Hospital, Charlestown, United States Impact: This research proposes a novel approach to investigate laminar-specific cortical changes, enabling a better understanding of normal aging and identifying potential early markers of neurodegeneration. The established methodology can be applied to various neurological conditions affecting cortical microstructure.
09:27		0758. Longitudinal DTI Changes are Associated with Centiloids in Adults with Down Syndrome: an Alzheimer’s Study View Presentation Video L. LeMerise, J. Guerrero-Gonzalez, A. McVea, S. Hartley, A. Alexander, B. Christian Unviersity of Wisconsin - Madison, Madison, United States Impact: Widespread bilateral regions showed direct significant diffusivity changes with CL changes. This suggests that changing white matter microstructure over time correlates with higher Aβ burden in adults with DS, indicating potential neurodegeneration and DTI as a means to assess it.
09:39		0759. Age-related Changes in Structural Connectivity in the HCP-Aging Data View Presentation Video Z. Liang, H. Pang, C. Li, J. Liu, Y. Ge, J. Zhang Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA. , New York, United States Impact: We have established a robust pipeline for reconstructing structural connectivity in the HCP-Aging dataset, and our findings suggest that aging increases the vulnerability of brain networks, potentially due to the high metabolic cost of maintaining an extensive network.
09:51		0760. Multimodal MRI Insights into Glymphatic Clearance and Blood-Brain Barrier Integrity in Healthy Aging View Presentation Video A. Bhattarai, Y. Zhu, B. Albuhwailah, P. Maillard, C. DeCarli, A. Fan University of California, Davis, Davis, United States Impact: This study provides novel multimodal MRI insights into how BBB integrity and glymphatic function are altered in healthy aging. These findings could pave the way for advancing MRI biomarkers aimed at preserving cognitive health in aging populations.
10:03		0761. DTI-ALPS associates with AD-signature region volumes, plasma biomarkers, and white matter hyperintensity progression View Presentation Video Q. Chen, B. Zhang Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China Impact: Worse glymphatic function indicates decreased AD-signature region volumes, severe WMH lesions, higher plasma ptau, and accelerated WMH progression. Therapies targeting the glymphatic system may prevent cognitive decline through the clearance of AD pathological proteins and the deceleration of WMH lesions.

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