ISMRM25 - Dementia & Other Neurodegeneration

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Dementia & Other Neurodegeneration

Oral

Neuro

Wednesday, 14 May 2025

323AB

15:45 - 17:45

Moderators: Yongxian Qian & Danny Wang

Session Number: O-64

No CME/CE Credit

15:45		1055. Impact of Frontotemporal Dementia on the Coupling of Cerebral Energy Metabolism to Neuronal Activity: A hybrid PET/MR study View Presentation Video M. Joshy, P. Dassanayake, L. Liu, M. Aiello, U. Anazodo, E. Finger, K. St. Lawrence University of Western Ontario, London, Canada Impact: Decoupling of cerebral glucose metabolism and functional connectivity is not limited to Alzheimer's, but evident in other neurodegenerative conditions. This dissociation is most associated with resting state networks impacted by the specific condition.
15:57		1056. Exploring the Link between Cerebral Small Vessel Disease and Alzheimer’s Disease with [11C]CS1P1, a Novel PET Tracer of Neuroinflammation View Presentation Video I. Orukari, Y. Wang, Y. Chen, B. Wang, K. Friedrichsen, M. Brier, Y. H. Nai, L. Jones, F. Rahmani, J-P Okafor, J. Rajamanickam, S. Flores, J-M Lee, A. Ford, Z. Tu, T. Benzinger, H. An Washington University in St Louis, St Louis, United States Impact: [¹¹C]CS1P1 PET could be a biomarker of early AD and cSVD. This imaging approach could guide the timely application of disease-modifying therapies and possibly enhancing treatment outcomes.
16:09		1057. DCE-MRI reveals elevated blood-brain barrier leakage of heterogeneous white matter in cerebral small vessel disease View Presentation Video D. Verstappen, J. de Jong, P. Voorter, M. van Dinther, M. Gidding, R. van Oostenbrugge, J. Staals, J. Jansen, W. Backes Maastricht University Medical Centre, Maastricht, Netherlands Impact: A more regionally targeted analysis is required to determine the subtle BBB leakage in the NAWM of patients with cSVD and to assess differences with controls.
16:21		1058. The role of venous hemodynamics in cerebral small vessel disease View Presentation Video W. Shi, D. Jiang, J. Song, Y. Gou, Z. Hu, K. Hazel, G. Pottanat, E. Jones, J. Suconic, C. Xu, V. Yedavalli, P. Rosenberg, R. Kalyani, A. Moghekar, S. Yasar, D. Lin, M. Albert, H. Lu Johns Hopkins University School of Medicine, Baltimore, United States Impact: Venous hemodynamics such as transit time and blood volume are associated with white matter hyperintensity and vascular risks. These measures may be useful as imaging markers to characterize venous abnormalities in cerebral small vessel disease.
16:33		1059. Choroid Plexus Enlargement related to tau deposition in progressive supranuclear palsy N. Wang, L. Liu, Y. Wu Fudan university, HuaShan hospital, Shanghai, China Impact: CP volume expansion may serve as a promising imaging biomarker of tau accumulation in PSP patients and could potentially be used to differentiate PSP from PD.
16:45		1060. Mapping Subjective Cognitive Decline to a Common Brain Network and Linking to Gene Expression Profiles View Presentation Video H. Lan, W. Liu, X. Suo, Q. Gong West China Hospital, Sichuan University, Chengdu, China Impact: Heterogeneous neuroimaging findings of SCD converge on common brain networks, which is linked to specific biological processes and neurotransmitters. This comprehensive understanding of the neural substrates underlying SCD may inform more targeted strategies to prevent dementia.
16:57		1061. Assessing regional brain magnetic susceptibility in Wilson’s disease using sub-voxel quantitative susceptibility mapping View Presentation Video Z. Huang, H. Wei, J. Chu First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Impact: The APART-QSM could precisely quantify the paramagnetic and diamagnetic properties in the brain in Wison’s disease. The present study offers significant insights into magnetic susceptibility perturbation of the deep brain nucleus in Wilson’s disease.
17:09		1062. Along-Tract Diffusion Alterations in the Dentato-Rubro-Thalamic Tract Correlate with Motor and Cognitive Decline in Huntington's Disease View Presentation Video Z. Wang, A. Solomon, G. Shao, J. Lupo, J. Yao University of California, Los Angeles, Los Angeles , United States Impact: This study reveals the DRTT's involvement in HD progression and underscores the importance of examining regional changes along the tract, providing valuable insights into white matter alterations and potential new biomarkers of motor and cognitive impairments in HD.
17:21		1063. Which Came First: Ventricular Enlargement or Abnormal CSF Circulation? View Presentation Video P. LIU, J. Xie, Y. Attekeble, K. Owashi, O. Balédent CHU Amiens-Picardie, University Hospital, Amiens, France Impact: The findings provide insights into the pathogenesis of hydrocephalus, offering potential markers for early diagnosis. Understanding the relationship between aqueduct resistance, Ratio-SV, and Ratio-Area may guide clinical practice and help identify early indicators of CSF dynamic disorders.
17:33		1064. Brain connectome gradient dysfunction in patients with ESRD and its association with clinical phenotype and cognitive deficits P. Li, L. Ren, Y. Yang, X. Zhu, H. Yuan, Z. Luo, J. Mu, W. Wang, M. Zhang The Second Affiliated Hospital of Air Force Medical University, Xi'an, China Impact: This is the first study to reveal the brain connectome hierarchical dysfunction in ESRD patients and its association with clinical phenotype and cognitive deficits, which might be used as an potential neuroimaging marker for clinical symptoms in ESRD patients.

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