ISMRM25 - Advances in White Matter Imaging

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Advances in White Matter Imaging

Oral

Neuro

Tuesday, 13 May 2025

311

15:45 - 17:45

Moderators: Cornelia Laule & Fanny Munsch

Session Number: O-65

No CME/CE Credit

15:45		0625. Automatic Multiple Sclerosis Lesion Segmentation in the Spinal Cord on 3T and 7T MP2RAGE images View Presentation Video N. Laines Medina, S. Mchinda, B. Testud, S. Demortière, M. Chen, G. Nair, D. Reich, C. Granziera, C. Tsagkas, V. Callot, J. Cohen-Adad Aix Marseille Univ, CNRS, CRMBM, Marseille, France Impact: This study presents a deep-learning-based method for MS lesion segmentation in the SC, which enhances diagnostic accuracy, reduces segmentation time, and offers lower variability compared to manual approaches, demonstrating significant potential to impact clinical practice and improve routine MS diagnosis
15:57		0626. Discriminating White/Gray matter in Cervical Spinal Cord by Myelin-Sensitive Inversion Recovery with Deep Learning Reconstruction at 1.5T MRI View Presentation Video K. Nitta, H. Yokota, T. Sada, R. Kurosawa, I. Nakanishi, H. Sato, K. Matsumoto, T. Namiki, M. Yoneyama, T. Iimori, T. Uno Chiba University Hospital, Chiba, Japan Impact: This research advances the field of myelin-specific MR imaging by demonstrating the feasibility of MySIR at 1.5T MRI with deep learning-based reconstruction. This technique provides an efficient way to visualize myelin, potentially improving the diagnosis of neurological diseases.
16:09		0627. Myelin water imaging in adolescent and young adult cancer patients and cognitive impairment: A feasibility longitudinal case-control study View Presentation Video E. J. Lim, C. Y. J. Goh, C. J. Tan, W. Lee, P. H. Chai, M. F. B. Harunal Rashid, A. Chan, S. Hartono, L. L. Chan Duke-NUS Medical School, Singapore, Singapore Impact: Myelin water fraction is a complementary quantitative marker to fractional anisotropy, detecting white matter dysmyelination in post-chemotherapy adolescent and young adult cancer patients.
16:21		0628. A Comparative Analysis of Different QSM Reconstruction Approaches for the Characterization of Multiple Sclerosis Pathology View Presentation Video A. Cagol, D. Gkotsoulias, M. Ocampo-Pineda, P-J Lu, X. Chen, M. Weigel, J. Kuhle, L. Kappos, M. P. Sormani, C. Granziera Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital and University of Basel, Basel, Switzerland Impact: QSM demonstrated substantial agreement across various acquisition and reconstruction methods and correlated with MS severity. The different QSM implementations exhibited small variations in sensitivity to pathological changes, underscoring the necessity for standardized protocols to enhance clinical application.
16:33		0629. Periventricular Gradient of Tissue Microstructure in Patients with MS, NMOSD, and MOGAD View Presentation Video M. Nakaya, A. Hagiwara, Y. Hoshino, Y. Tomizawa, W. Uchida, T. Sekine, N. Hara, Y. Tsukamoto, J. Kikuta, S. Kamio, C. Andica, K. Kamagata, M. Hori, A. Wada, O. Abe, N. Hattori, S. Aoki Juntendo University, Tokyo, Japan Impact: Periventricular gradient of myelin content in MS is distinct from NMOSD and MOGAD. The correlation between myelin gradients and clinical measures in MS provides insights into disease progression and may guide personalized treatment strategies.
16:45		0630. Accelerated mI/tNAA Increase in Normal-Appearing WM of RRMS with Paramagnetic Rim Lesions: A 7T MR Spectroscopic Imaging 2-year Follow-Up Study View Presentation Video A. Zöchner, W. Bogner, A. Dal-Bianco, B. Strasser, G. Hangel, P. Rommer, E. Niess Medical University of Vienna, Vienna, Austria Impact: Results revealed faster increase in mI/tNAA in the NAWM of patients with >1 PRL, which may indicate elevated inflammation. This could explain the transition from relapsing-remitting MS to progressive forms and identify mI/tNAA as potential biomarker for MS progression.
16:57		0631. Uncovering fibrin(ogen) deposition in multiple sclerosis brain by in vivo 64Cu-FBP8 MR-PET imaging View Presentation Video C. Treaba, C. Catana, E. Klawiter, S. Huang, R. Bakshi, A. Misscioscia, E. Barbuti, R. Bomprezzi, J. Sloane, S. Tauhid, G. Arabasz, P. Caravan, C. Mainero Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, United States Impact: ⁶⁴Cu-FBP8 MR-PET imaging allows in vivo quantification of fibrin(ogen) levels and could aid in predicting MS disease outcomes and improve patient management strategies. Further research is needed to validate its use as a reliable biomarker in clinical practice.
17:09		0632. Alterations in white matter tract myelination in carriers of copy number variations at the 16p11.2 locus View Presentation Video W. D. Lu, C-O Martin, K. Jizi, M. Nelson, S. Jacquemont, C. Tardif McGill University, Montreal, Canada Impact: This quantitative MRI study demonstrates for the first time that 16p11.2 CNV carriers exhibit altered myelination of their white matter tracts. Future work will investigate the association between network myelination and brain function.
17:21		0633. Microstructure fingerprints of white matter hyperintensities in the aging brain View Presentation Video A. Bussy, C. Cathala, F. Kherif, A. Lutti, B. Draganski Inselspital, Bern, Switzerland Impact: This study offers unique insights into white matter hyperintensities (WMH), demonstrating characteristic patterns of myelin and axonal loss. Our findings highlight the importance of advanced imaging techniques to better understand the complexities of WMH and their impact on brain health.
17:33		0634. Microstructural and susceptibility alterations in white matter and cerebellum are linked to fatigue and cognitive dysfunction in long COVID View Presentation Video E. Grosso, N. Kozhanova, M. Gaviraghi, E. Lupi, A. Monteverdi, M. Yiannakas, A. Ricciardi, M. Battiston, F. Grussu, R. Samson, F. Prados, B. Kanber, M. Shatila, M. Zandi, C. Tur, E. D'Angelo, F. Palesi, C. Gandini Wheeler-Kingshott University of Pavia, Pavia, Italy Impact: This work impacts on our understanding of fatigue and cognitive impairment, impactful symptoms of the long-COVID syndrome, emphasizing the role of diffusion MRI and susceptibility mapping models in detecting microstructural and susceptibility alterations voxel-wise.

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