ISMRM25 - Emerging Contrasts in Neurofluids

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Emerging Contrasts in Neurofluids

Oral

Neuro

Monday, 12 May 2025

310 (Lili-u Theater)

16:00 - 18:00

Moderators: Laura Lewis & Minako Azuma

Session Number: O-66

No CME/CE Credit

16:00		Introduction Laura Lewis
16:12		0245. Bidirectional BOLD-CSF coupling using sagittal BOLD imaging with additional saturation slab for glymphatic function assessment PDF Poster View Presentation Video E. Roefs, I. Eiling, N. Fultz, L. Hirschler, M. van Osch Leiden UMC, Leiden, Netherlands Impact: Interest in BOLD-CSF coupling is increasing in clinical studies as a measure of brain clearance efficiency. We propose a new bi-directional sagittal approach that could give more robust BOLD-CSF coupling and later potentially quantitative bi‑directional CSF-flow extending on modelling approaches.
16:24		0246. Anesthetics Modulate Cerebrospinal Fluid Efflux Pathways in Mice by Changing the Perineural and Perivascular Spaces View Presentation Video H. Ge, X. Gu, S. Tan, B. Jiao, Q. He, L. Zhang, R. Bai Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China Impact: Different anesthesia protocols could affect the CSF outflow pathways, and the CSF volume changes under different anesthesia protocols are the potential mechanism.
16:36		0247. Three-dimensional T1 measurement in the cerebrospinal fluid using the SPACE-FLAIR sequence View Presentation Video E. Biondetti, S. Pomante, S. Censi, D. Di Censo, E. Bliakharskaia, M. Carriero, F. Graziano, A. Caporale, A. Chiarelli, R. Wise University "G. D'Annunzio" of Chieti-Pescara, Italy, Chieti, Italy Impact: We propose a high-resolution 3D protocol for investigating relative differences in T1 across the cerebral CSF due to tissue-CSF water exchange. This methodology may help characterise processes of waste removal from the brain to which CSF is thought to contribute.
16:48		0248. SORDINO for mapping glymphatic dynamics and choroid plexus efflux View Presentation Video S. Lee, T-W Wang, M. MacKinnon, S. Song, S. Ozarkar, M. Shen, B. Philpot, Y-Y Shih The University of North Carolina at Chapel Hill, Chapel Hill, United States Impact: This study pioneers the use of SORDINO MRI, a silent, distortion-free, motion-insensitive, and efficient T1-sensing sequence, to map glymphatic dynamics or choroid plexus efflux, enabling functional segmentation of brain ventricular spaces and the choroid plexus for studying brain fluid dynamics.
17:00		0249. Assessing cerebral microvascular pulsatility using dynamic pseudo-continuous arterial spin labeling MRI View Presentation Video T. Zhao, J. Tang, M. Gamez, L. Yan Northwestern University, Chicago, United States Impact: We proposed a non-invasive MRI technique to reliably measure cerebral microvascular pulsatility, which fills a significant research gap in research related to brain waste clearance.
17:12		0250. Increased vasomotor waves inverts electro-hydrodynamic drive over blood-brain-barrier in sleep. View Presentation Video V. Kiviniemi, T. Väyrynen, H. Helakari, V. Korhonen OFNI, Univeristy of Oulu, Oulu, Finland Impact: Sleep induces vasomotor waves that start to drive both brain water and BBB signals in the same posterior/middline areas in sleep adding further proof to the previous findings of increased solute transport in parasagital areas.
17:24		0251. Probing Glymphatic Exchange Between CSF and Tissue Using Long-TE Arterial Spin Labeling: Simplified Model and Shorter Scan Time View Presentation Video Z. Wang, Z. Hu, D. Jiang, D. Sankaralayam, H. Fan, J. Song, Y. Gou, W. Shi, Y. Ge, H. Lu Johns Hopkins University, Baltimore, United States Impact: In this study, we developed a framework to measure CSF signal fraction in ASL MRI, which may provide a physiological index to evaluate tissue CSF dynamics and brain waste clearance system.
17:36		0252. 3-Tesla Parasagittal dural space (PSD) T2 relates to PSD volume and correlates with diurnal circadian oscillation during wakefulness View Presentation Video K. Hett, M. Leguizamon, C. McKnight, A. Song, C. Han, A. Dubois, M. Curtin, M. Garza, P. Trujillo, C. Considine, D. Claassen, M. Donahue Vanderbilt University Medical Center, Nashville, United States Impact: The T₂ relaxation times of water in the parasagittal dural (PSD) space were quantified over the circadian cycle of wakefulness at using a long-TE multi-echo turbo-spin-echo sequence. PSD T₂ was 240.6±57.2 ms on average and increased from morning to evening.
17:48		0253. Visualization of Glymphatic Route on the Rat Cerebral Surface Using Direct Injection of 17O-Labeled Water and Proton MRI View Presentation Video H. Kameda, T. Fujii, N. Kinota, D. Kato, Y. Bito, M. Tang, K. Kudo Hokkaido University Hospital, Sapporo, Japan Impact: Using the technique of local subarachnoid injection of ¹⁷O-labeled water and an optimiszd proton MRI method, we were the first to visualize CSF inflow pathways in the cerebral cortex as distinct signal changes.

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