ISMRM25 - Imaging the Epileptic Brain

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

ISMRM & ISMRT 2025 Annual Meeting & Exhibition

Oral

Imaging the Epileptic Brain

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Imaging the Epileptic Brain

Oral

Neuro

Monday, 12 May 2025

311

13:45 - 15:45

Moderators: Vishal Patel & Victoria Morgan

Session Number: O-67

CME Credit

13:45		Introduction Vishal Patel
13:57		0136. First observation in a human of real-time BOLD-fMRI response to epileptic seizure View Presentation Video G. Sighinolfi, G. Vornetti, E. Pasini, E. Cantoni, L. Ferri, D. N. Manners, M. Martinoni, R. Michelucci, R. Lodi, C. Tonon IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Impact: This is the first description of real-time BOLD response to an in-scanner epileptic seizure in a human and improves our knowledge on the mechanisms of brain function following such events.
14:09		0137. Advanced Deep Learning Models Enhance Piriform Cortex Segmentation for Epilepsy Surgery View Presentation Video J. Urriola Yaksic, L. Lebrat, H. Min, A. Pagnozzi, Y. Xia, I. Vati, C. X. Li, S. Weeratunga, M. Courney, J. Fripp, M. Gutman, A. Neal, B. Sinclair, T. J. O'Brien, D. Bradford Australian E-Health Research Centre, CSIRO, Brisbane, Australia Impact: Advanced DL models with attention mechanisms, such as MedNeXtL and SwinUNETR, significantly enhance piriform cortex segmentation accuracy. This improvement holds promise for refining surgical margins for patients with drug-resistant temporal lobe epilepsy, potentially leading to better postsurgical outcomes.
14:21		0138. Automated Whole-brain Focal Cortical Dysplasia Detection using MR Fingerprinting with Deep Learning View Presentation Video Z. Ding, S. Morris, S. Hu, T-Y Su, J. Y. Choi, I. Blümcke, X. Wang, K. Sakaie, H. Murakami, A. Alexopoulos, S. Jones, I. Najm, D. Ma, Z. Wang Cleveland Clinic, Cleveland, United States Impact: Multiparametric MRF features from a single scan provide promising inputs for developing an AI tool to detect subtle epileptic lesions, enhancing noninvasive presurgical evaluation for patients with pharmacoresistant epilepsy.
14:33		0139. Collaborative Multi-Task Radiomics Models to Identify IDH Mutation Status and Epilepsy in Patients with Gliomas View Presentation Video Y. Wang, A. Gao, H. Yang, J. Bai, G. Zhao, H. Zhang, Y. Song, C. Wang, Y. Zhang, J. Cheng, G. Yang East China Normal University, Shanghai, China Impact: The collaborative radiomics models exploited the underlying connections between IDH status and epilepsy identification tasks with fewer features, improved the model performance, and can potentially been used to find valuable generalized biomarkers for multiple clinical problems.
14:45		0140. Hippocampal myo-inositol correlates with worse cognitive measures in temporal lobe epilepsy View Presentation Video M. Uberti, B. Sajja, A. Mullane, K. Greenman, Y. Zhang, M. White, O. Taraschenko University of Nebraska Medical Center, Omaha, United States Impact: This study could significantly impact public health by revealing how brain inflammation contributes to cognitive loss in TLE. It may open doors to new treatments focused on preserving cognitive health in other epilepsy patients, potentially improving their quality of life.
14:57		0142. Deuterium MR with a glucose-transporter-1 deficiency syndrome mouse model: ketogenic diet-modulated brain energy metabolism View Presentation Video J. Garbow, X. Ge, N. Rensing, J. Engelbach, L. L. Thio, J. Neil, J. Ackerman Washington University School of Medicine, Saint Louis, United States Impact: DMI is directly clinically translatable. These results suggest it holds promise for quantification of the metabolic changes in GLUT1-DS patients, thereby relating these changes to the underlying pathophysiology, clinical symptoms and treatment efficacy in individual patients.
15:09		0143. A Graph Theory based Pipeline for Intraoperative Resting-State fMRI Analysis View Presentation Video N. Weilguny, R. Licandro, M. Tomschik, G. Kasprian, K. Rössler, C. Dorfer, G. Hangel Medical University of Vienna, Vienna, Austria Impact: We demonstrated the feasibility of pre- and post-surgery data preprocessing, which enables intraoperative fMRI analysis using graph theory, allowing investigation of functional changes during brain surgery. This approach may lead to future improvements in neurosurgical outcomes.
15:21		0144. Human functional network modulated by focused ultrasonic stimulation of the hippocampus View Presentation Video H-J Lee, J-H Hsieh, H-Y Yu, C-J Lee, C-C Chou, Y-C Shih, P-T Lin, W-J Kuo, F-H Lin Sunnybrook Research Institute, Toronto, Canada Impact: We presented neuroplastic evidence of functional connectivity change induced by FUS at the human hippocampus. Our results show the re-organization of the functional connectivity with changes within (precunues and medial prefrontal cortex) and beyond typical nodes in the hippocampal network.
15:33		0145. Universal Pulses Enable a One-Hour Clinical Neuroimaging Protocol at Submillimeter Resolution on the NextGen 7T View Presentation Video E. Walker, A. Vu, P. Mukherjee, N. Boulant, V. Gras, F. Mauconduit, A. Massire, P. Krahn, C. Liu, A. Beckett, D. Feinberg University of California, Berkeley, Berkeley, United States Impact: Universal Pulses provide a seamless solution to mitigate the RF field inhomogeneity problem for neuro MRI at 7T, enabling clinical populations to benefit from fast, high-resolution anatomical imaging without the need for dielectric pads.
15:45		0141. WITHDRAWN

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