Kevin Chan

S. Swegle, R. Huber, R. Stirnberg, P. Molfese, L. Li, C. Walsh, A. T. Morgan, P. Bandettini
NIH, Bethesda, United States

Impact: We present a method to capture dynamic CSF volume changes independent of CBV and BOLD during different states of neural activity and drowsiness. This could aid research on CSF’s role in waste removal from the brain in diseases like Alzheimer’s.
 

Impact: This study highlights robust, respiration-driven hydrodynamics in the parenchyma, with inhalation slowing and exhalation accelerating fluid motion.

Impact: This work solves the problem of low inter-observer and scan-rescan repeatability in DTI-ALPS by semi-automatically selecting voxels having medullary veins perpendicular to fiber orientation (DTI-ALPS-Plus), which also enhances this method’s sensitivity to ISF dynamics.

F. Wang, T. Reese, B. Rosen, L. Wald, L. Lewis, J. Polimeni, Z. Dong
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, United States

Impact: We demonstrate that neural-activation-related hemodynamic responses induce significant directional subarachnoid-CSF flow. Test-retest experiments showed that the spatial patterns and flow pathways are reproducible across runs and subjects. These findings suggest that brain activity can effectively modulate subarachnoid-CSF flow.

N. Fultz, E. Roefs, M. Nagtegaal, M. van Osch, L. Hirschler
Leiden University Medical Center, Leiden, Netherlands

Impact: The reduced T2 values observed in the PVS suggest the presence of 'dirty' CSF, supporting the idea that MR-visible PVS, primarily associated with arteries, may serve not only as channels for fresh CSF inflow but as mixing-sites of waste products.

J. Jang, J. Lee, H. Kim, W-J Moon, K. S. Choi
Seoul National University, Seoul, Korea, Republic of

Impact: Our proposed method may enable automatic segmentation of the PSD and mLVs in cases of highly limited spatial resolution, where manual segmentation may be impractical.

Impact: We used CO₂ modulation to highlight the involvement of slow-wave heart-rate and respiratory variability in modulating neurofluid flow, implicating the autonomic nervous system. This demonstrates that it is possible to modulate neurofluid flow through other means than sleep.

J-H Kim, R-E Yoo, S-H Park, S. H. Choi
Seoul National University, Seoul, Korea, Republic of

Impact: The results demonstrate that long-term exercise can enhance glymphatic and mLV flow, which may underlie the neuroprotective effects of exercise. These findings could lead to new interventions for preventing neurodegenerative diseases by enhancing brain waste clearance mechanisms.

Impact:

BCSFB permeability metrics derived from our novel tracer kinetic model, demonstrated significant correlations with BBB permeability and cognitive function. These findings suggest that BCSFB permeability could serve as a valuable imaging biomarker for comprehensive diagnostic metric together with BBB permeability.