ISMRM25 - Multimodal Imaging Approaches to Psychiatric Disorders

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Multimodal Imaging Approaches to Psychiatric Disorders

Oral

Neuro

Thursday, 15 May 2025

311

08:15 - 10:15

Moderators: Khin Tha & Geon-Ho Jahng

Session Number: O-70

No CME/CE Credit

08:15		1124. Edge-centric connectome representation reveal altered brain functional diversity in patients with major depressive disorder View Presentation Video K. Qin, L. Zhang, N. Pan, W. Liu, W. Chen Taihe Hospital, Shiyan, China Impact: This study demonstrated that edge-centric connectome could serve as a valuable complement to node-centric approaches, offering deeper insights into the neurobiological mechanisms related to functional diversity abnormalities in MDD and highlighting its promising clinical application value for diagnosis.
08:27		1125. Structural-functional coupling subtypes of major depressive disorder and their associations with genetic and neurotransmitter profiles View Presentation Video H. Gao, R. Qian, Y. Ma, B. Gu, T. Jin, D. Wu, Z. Zhao Zhejiang University, Hangzhou, China Impact: Our study identified two neurophysiological subtypes of MDD, characterized by unique SFC alteration patterns, along with specific associations with genetic and neurotransmitter profiles. These subtypes may offer promising implications for personalized diagnosis and targeted treatment of MDD.
08:39		1126. Direct and Quantitative Assessment of Brain Bioenergetics in Young Adults with Depression View Presentation Video X-H Zhu, H. Wiesner, B. Klimes-Dougan, W. Chen, K. Cullen Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, United States Impact: We demonstrate that the ³¹P MRS-MT imaging technique is able to quantitatively evaluate key bioenergetic parameters in the human brain, revealing new insights into the cerebral energetic alterations underlying fatigue in young adults with depression.
08:51		1127. Quantitative Susceptibility Mapping of Subcortical Regions in Major Depression Using Susceptibility Separation Technique View Presentation Video S. Shibukawa, H. Kan, S. Nakajima, Y. Noda, S. Koike The University of Tokyo, Tokyo, Japan Impact: QSM-ARCS revealed iron and myelin changes in the subcortical structures of MDD, deepening understanding of MDD pathophysiology and highlighting its potential to advance future diagnostic and therapeutic strategies.
09:03		1128. Depression and somatic improvement following rTMS therapy may be predicted by Glx/tCr ratio – preliminary findings View Presentation Video P. Bhattacharyya, A. Anand, J. Lin, M. Altinay Cleveland Clinic Foundation, CLEVELAND, United States Impact: Hamilton depression (HAMD) scale is a composite measure. Findings from this study identified specific symptom-based components of HAMD that are specifically changed depending on dorsolateral prefrontal cortex (glutamate+glutamine)/creatine ratio. This may help in mechanistic understanding of rTMS therapy.
09:15		1129. Cortical macro- and microstructure dependence as a potential biomarker in psychiatric disorders with excitatory symptoms L. Wei, X. Fang, S. Hu, H. Wang Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, ShangHai City, China Impact: Our findings highlight CMD as a promising biomarker for bipolar disorder, offering insights into its neurobiological mechanisms. This research paves the way for new inquiries into the relationship between cortical structure and psychiatric symptoms, potentially guiding future therapeutic interventions and patient management.
09:27		1130. Laminar-specific topological alterations in schizophrenia and their association with clinical features: a submillimeter DTI study View Presentation Video N. Liu, K. Prasad, X. Li, H. Sun, H. Liang, W. Zhang, S. Lui West China Hospital of Sichuan University, Chengdu, China Impact: This study revealed that topological alterations in schizophrenia exhibit laminar-specific characteristics and their associations with clinical features, which might enhance our understanding of the pathophysiology of schizophrenia from a mesoscopic perspective.
09:39		1131. Thalamic GABA and Glutamate Imbalance Associates with Cortical Degeneration in Early Psychosis: A 7T MRI Study View Presentation Video Z. Wang, Y. Gómez, M. Cleusix, R. Jenni, L. Alameda, P. Conus, M. Cuadra, P. Hagmann, K. Do, L. Xin Animal imaging and technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland Impact: This study enhances understanding of early psychosis by linking altered GABA and glutamate levels in the thalamus to cortical structural changes, supporting the role of excitation and inhibition imbalance in thalamocortical dysfunction in psychosis and highlighting the potential for targeted interventions.
09:51		1132. Cross-species quantification of the effect of ketamine on gray matter microstructure in obsessive-compulsive disorder View Presentation Video S. Ewbank, A. Hart, E. Dai, D. Gopal, R. St. Laurent, I. Vo, O. Magana, P. Mukunda, J. McNab, C. Rodriguez, R. Airan Stanford University, Stanford, United States Impact: Gold standard approaches for preclinically quantifying drug-induced structural neuroplasticity involve histology and therefore cannot be applied for clinical purposes. We investigated across species whether gray matter microstructure quantification could bridge this gap in the context of ketamine’s rapid anti-obsessional effects.
10:03		1133. Exploring Functional and Structural Connectivity as Markers of Atherosclerotic Burden in Chronic Stress View Presentation Video D. O'Connor, M. van Leent, P. Robson, A. Kaufman, M. G. Trivieri, L. Shin, A. Tawakol, Z. Fayad Icahn School of Medicine Mount Sinai, New York, United States Impact: Sensorimotor cortices, and their connectivity with the amygdala, proved surprisingly relevant for distinguishing individuals with high atherosclerotic burden from those with low burden. While the prefrontal cortex is crucial to understanding stress-CVD relationships, sensorimotor contributions should not be disregarded.

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