Oral
Preclinical Brain Imaging: Emerging Technologies & Applications
ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i
Oral
Preclinical Brain Imaging: Emerging Technologies & Applications
| 13:15 |
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1234. Simultaneously
imaging protein aggregation and iron in patients with
synucleinopathies using sub-voxel magnetic susceptibility
imaging
Z. Li, H. Wei
Shanghai Jiao Tong Unverisity, Shanghai, China
Impact: This study confirms that diamagnetic signals
reconstructed through sub-voxel QSM can measure α-synuclein
aggregation in the brains of synucleinopathy patients. Our
preliminary findings indicate that sub-voxel QSM holds
significant promise as an MRI technique for monitoring
neurodegeneration in synucleinopathies.
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| 13:27 |
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1235. SWI
Study on α-Synuclein Monkey Model of Parkinson's Disease and
Patients with Parkinson's Disease
G. Xie, K. Wu, Y. Wu
The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang CIty, China
Impact: This study establishes the α-syn monkey model as
a valuable tool for investigating the pathophysiologic
mechanism behind the brain imaging changes in PD, enhancing
the understanding of iron deposition and aiding in the
search for early diagnostic markers.
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| 13:39 |
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1236. Sex-specific
brain patterns of pain with comorbidities in mice
L. Degiorgis, M. Sourty, M. Rame, M. Mondino, V. Noblet, X.
Yi Kong, A. Rodriguez-Lopez, B. Alvarez-Perez, C. Sivert
Nielsen, R. Maldonado, B. Halvorsen, L-A Harsan
Laboratory of Engineering, Informatics and Imaging (ICube), University of Strasbourg-CNRS, Strasbourg, France
Impact: We studied a unique cohort of 300 outbred male
and female mice to model human-like chronic pain and
atherosclerosis, and our findings revealed sex-dependent
brain architecture changes in mice with pain and
comorbidities.
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| 13:51 |
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1237. Longitudinal
assessment of changes in the BBB water permeability in a mouse
model of Huntington's Disease using multi-TE ASL MRI
J. van Rijswijk, J. Van Audekerke, I. Van Spilbeeck, Y.
Ohene, J. Wells, T. Vasilkovska, H. Tang, R. Cachope, D.
Pustina, M. Adhikari, D. Bertoglio, M. Verhoye
Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium
Impact: This study indicates that using the non-invasive
multi-TE ASL MRI technique, alterations in water exchange
time can be detected in the zQ175DN mouse model of
Huntington’s Disease at 9 months of age.
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| 14:03 |
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1238. Influence
of Infusion Location, Rate, and Anesthesia on CSF Tracer
Dynamics in Mouse Brain
Y. Zhu, J. Zhu, C. Ni, A. Chen, L. Li, Y. Gao, A.
Shoffstall, X. Yu
Case Western Reserve University, Cleveland, United States
Impact:
This study investigated the impact of infusion location, rate, and anesthesia on Gd-DTPA transport dynamics and distribution patterns across the whole brain, providing insights into CSF transport pathways and regulation in the brain. |
| 14:15 |
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1239. Imaging
the Ischemic Penumbra with IVIM
M. Liu, N. Saadat, S. Roth, M. Shazeeb, M. Giurcanu, T.
Carroll, G. Christoforidis
University of Chicago, Chicago, United States
Impact: As IVIM is a non-contrast method that includes
compensatory collateral supply, it poses itself to be a
viable candidate for longitudinal measurement of
simultaneous perfusion and diffusion in pre-clinical stroke
research.
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| 14:27 |
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1241. Linking
neuron-axon-synapse architecture to white matter vasculature
using high-resolution multimodal MRI in primate brain
I. Kimura, T. Hayashi, J. Autio
DRCMR, Copenhagen, Denmark
Impact: Submillimeter ferumoxytol-weighted MRI shows
considerable potential to chart vascularity in white matter.
The blood volume in white matter is linked to
neuron-axon-synapse architecture.
|
| 14:39 |
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1242. A
porcine model of realistic closed-head impacts with
multiple-timepoint MRI
M. Georgiadis, X. Zhan, H. Moein Taghavi, K. Heng, J.
Nirschl, J. Towns, V. Tac, Y. Wang, W. Ho, S. Margulies, M.
Hajiaghamemar, G. Grant, K. Setsompop, C. Liao, D.
Camarillo, M. Zeineh
Stanford University School of Medicine, Stanford, United States
Impact: Our novel large-animal linear-impact head impact
model can detect injury with pre- and post-impact in vivo
and ex vivo MRI, pathology, and finite-element modeling.
This paradigm can uncover the microstructural,
biomechanical, and molecular mechanism of head
impact-induced brain injury.
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| 14:51 |
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1243. Hubness
of Paraventricular Thalamic Nucleus Predicts Thalamocortical
Connectivity Changes Driven by Locus Coeruleus Activity
L. Hsu, C. Meng, G. Cui, P. Jensen, Y-Y Shih
University of North Carolina at Chapel Hill, Chapel Hill, United States
Impact: This work reveals how the hubness of specific
thalamic nuclei modulates thalamocortical circuits, offering
insights into individual variability in LC-related behavior
and potential implications for treating neuropsychiatric
disorders.
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| 15:03 | 1240. WITHDRAWN |
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