ISMRM25 - fMRI: Rethink Everything

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

fMRI: Rethink Everything

Power Pitch

fMRI

Monday, 12 May 2025

Power Pitch Theatre 1

13:45 - 15:45

Moderators: Renzo Huber & Jonathan Polimeni

Session Number: PP-13

No CME/CE Credit

13:45		Screen Number: 1 0195. Cerebrovascular reactivity mapping without gas inhalation: signal characterization with multi-echo BOLD View Presentation Video O. Akinwale, Z. Hu, E. Yacoub, P. Liu, H. Lu Johns Hopkins University School of Medicine, Baltimore, United States Impact: Breath-modulation resulted in an EtCO2 reduction by ~2.5mmHg. In terms of the BOLD acquisition sequences, ME-BOLD T2* CVR yielded a similar precision as the SG-BOLD, but with higher accuracy. Breath-modulation MRI can also yield reliable bolus arrival time maps.
13:47		Screen Number: 2 0196. Metabolic response in deactivated areas using fMRS at 3T View Presentation Video L. Cairone, M. Guidi, A. Napolitano, S. Mangia, F. Giove 'La Sapienza' University of Rome, Rome, Italy Impact: Neurometabolic profiling during deactivation can help elucidating the neural origin of NBR, offering information about brain metabolic diseases through assessment of dissociation between neurovascular and neurometabolic coupling. Lactate and glutamate decreases are coherent with reduced excitation within the deactivated area.
13:49		Screen Number: 3 0197. Decoupling of Global Brain Activity and Cerebrospinal Fluid Dynamics in Obstructive Sleep Apnea: Links to Disease Severity and Hypoxemia View Presentation Video Z. Xiong, Y. Yang, Y. Zhou, Z. Wang, J. He, L. Nie, R. Wang, X. Zeng Guizhou Provincial People’s Hospital, Guiyang, China Impact: This study reveals how OSA disrupts brain-CSF interactions and suggests that gBOLD-CSF coupling may serve as a biomarker for diagnosis and treatment. Future research should explore whether improving oxygenation or sleep quality can restore coupling and enhance cognitive function.
13:51		Screen Number: 4 0198. Myelination selectively modulates BOLD signal characteristics in white matter: from myelin content to gene expression View Presentation Video Y. Gao, L. Xu, K. Schilling, S. Choi, R. Chen, Y. Li, M. Li, Z. Zu, Z. Ding, A. Anderson, J. Gore Vanderbilt University, Nashville, United States Impact: This study demonstrates a heterogeneous dependence of white matter functional signals on myelin, supported by both in-vivo MRI evidence and gene expression data, while confirming a strong effect of vascular density on BOLD effects
13:53		Screen Number: 5 0199. WITHDRAWN
13:55		Screen Number: 6 0200. Repeated functional magnetic resonance imaging of the lumbosacral cord during electrical stimulation of the tibial nerve View Presentation Video C. Kündig, S. Büeler, M. Liechti, T. Kessler, P. Freund, G. David Balgrist University Hospital, University of Zurich , Zurich, Switzerland Impact: BOLD fMRI of the lumbosacral cord during transcutaneous electrical tibial nerve stimulation is feasible, and the required scan times of 24 minutes are clinically achievable. The differences between sessions suggest an impact of habituation, warranting further investigation.
13:57		Screen Number: 7 0201. Neural correlates of aberrant pain processing and modulation in fibromyalgia: a simultaneous spinal cord-brain fMRI study View Presentation Video D. Pfyffer, M. Kaptan, C. Law, K. Weber II, V. Oliva, S. Bédard, T. Indriolo, T. Maronesy, G. Glover, S. Mackey Stanford University School of Medicine, Palo Alto, United States Impact: Identification of dysfunctional networks involved in pain modulation along the neuroaxis might present promising neural targets for more efficient treatment of chronic pain (e.g., non-invasive brain or spinal cord stimulation) and advance the development of pain biomarkers and precision medicine.
13:59		Screen Number: 8 0202. Investigation of sustained blood flow and metabolic changes in the healthy brain following motor learning View Presentation Video D. Di Censo, S. Censi, F. Graziano, E. Patitucci, M. Carriero, S. Pomante, F. Procida, F. Tomaiuolo, M. G. Tullo, M. Germuska, E. Biondetti, A. Caporale, A. Chiarelli, V. Tomassini, R. Wise University 'G. D'annunzio' of Chieti-Pescara, Chieti, Italy Impact: These results provide a framework for investigating learning-related brain blood flow and metabolic changes that may sustain long-term plasticity relevant for mitigating neurological conditions.
14:01		Screen Number: 9 0203. Mapping inter-brain synchrony in awake, socially interacting mice using SORDINO hyperscanning PDF Poster View Presentation Video T-H Chao, S. Song, M. MacKinnon, S-H Lee, L-M Hsu, R. Nonneman, Y-Y Shih The University of North Carolina at Chapel Hill, Chapel Hill, United States Impact: We demonstrated a robust large-scale inter-brain synchronization in socially interacting mice using a novel, silent, motion-insensitive SORDINO-fMRI hyperscanning method, enabling future exploration of neural circuit- and network-level mechanisms behind inter-brain synchronization that are challenging to investigate with conventional approaches.
14:03		Screen Number: 10 0204. Resolving T2 and T2' contributions to BOLD response speed and nonlinearity using 7T EPTI View Presentation Video D. Gomez, B. Ashenegar, Z. Hu, H. Fisher, Z. Dong, F. Wang, J. Polimeni, L. Lewis Massachusetts General Hospital, Charlestown, United States Impact: We tested whether pure-T2 signals BOLD can enable more specific BOLD responses by simultaneously measuring pure-T2 and T2’ contributions using spin-echo echo-planar time-resolved imaging. Pure-T2 weighting decreased the non-linearity of BOLD responses and reduced response time-to-peak by hundreds of milliseconds.
14:05		Screen Number: 11 0205. Multiecho Cardiac-Gated fMRI Enhances Activation Detection in Simultaneous Brain-Spinal Cord Imaging View Presentation Video C. Law, M. Kaptan, D. Pfyffer, Y. Wang, K. Weber II, S. Mackey, G. Glover Stanford University, Stanford, United States Impact: This study demonstrates that multiecho cardiac-gated fMRI enhances spinal cord activation detection, enabling more precise brain-spinal cord connectivity mapping. This advancement could refine clinical assessments of pain and motor disorders, driving further exploration of physiological noise reduction techniques in neuroimaging.
14:07		Screen Number: 12 0206. In vivo Detection of Mouse Visual Sensory Pathways using Multi-Slice DIANA fMRI View Presentation Video J-Y Keum, P. T. Toi, J. Park, J-Y Park Sungkyunkwan University, Suwon, Korea, Republic of Impact: The implementation of multi-slice DIANA fMRI with millisecond temporal resolution is expected to enhance our understanding of mouse visual pathways, revealing new insights into brain circuitry and supporting the development of dynamic brain network models.
14:09		Screen Number: 13 0207. Zero echo time fMRI enables artifact-free whole-brain functional imaging at 16.4T View Presentation Video J. Valjakka, S. Ponticorvo, L. Wu, D. Koski, R. Salo, D. Idiyatullin, J. Paasonen, O. Gröhn, S. Michaeli, S. Mangia University of Eastern Finland, Kuopio, Finland Impact: This work demonstrates that zero echo time fMRI can overcome the limitations that T2/T2*-weighted EPI faces at ultra-high field, having the potential to facilitate the advancement of ultra-high field whole-brain functional imaging.
14:11		Screen Number: 14 0208. Mapping Hand Function in the Brain and Spinal Cord with Simultaneous Brain-Spinal Cord Functional MRI View Presentation Video V. Oliva, S. Bédard, A. Smith, M. Kaptan, D. Pfyffer, B. Chy, S. Aufrichtig, N. Berhe, J. Ratliff, S. Hu, Z. Smith, T. Hastie, S. Delp, S. Mackey, G. Glover, A. Chaudhari, C. Law, K. Weber II Italian National Institute of Health, Rome, Italy Impact: We mapped brain and SC neural correlates of hand function showing activations and deactivations in sensory and motor regions, providing a more complete picture of motor control.
14:13		Screen Number: 15 0209. Zero echo time MB-SWIFT fMRI in rat spinal cord during hind paw stimulation - correlation with electrical activity View Presentation Video P. Stenroos, I. Gureviciene, H. Laakso, R. Salo, E. Paasonen, J. Paasonen, S. Michaeli, S. Mangia, H. Tanila, O. Gröhn A.I. Virtanen Institute, Kuopio, Finland Impact: MB-SWIFT fMRI provides a valuable experimental tool for assessing stimulation evoked response in the spinal cord, validated here to have good agreement with electrical activity.
14:15		Screen Number: 16 0210. Early Cortical Reorganization in the Sensorimotor Network Following FES Cycling Intervention in Individuals with Chronic SCI. View Presentation Video L. Ismaila, C. Sadowsky, A. Choe Johns Hopkins University School of Medicine, Baltimore, United States Impact: Our findings reveal FES-induced reorganization within the sensorimotor network of the SCI group at the post-FES stage. This could guide clinicians, researchers, and rehabilitation specialists in using rs-fMRI to observe early cortical changes, even when measurable motor improvements are absent.
14:17		Screen Number: 17 0211. Emerging Patterns of Thalamocortical Connectivity in Early Brain Development View Presentation Video W. Lyu, K-H Thung, K. Huynh, S. Ahmad, P-T Yap University of North Carolina at Chapel Hill, CHAPEL HILL, United States Impact: We present the first map of thalamocortical connectivity across early childhood, showing its dynamic changes over this period. Our findings suggest a developmental gradient in thalamic function, traversing from posterior to anterior and from lateral to medial regions.
14:19		Screen Number: 18 0212. Individualized Functionnectome for the detection of white matter circuits underlying task-fMRI activations in glioma patients View Presentation Video G. Sighinolfi, A. De Luca, D. N. Manners, R. Lodi, C. Tonon, A. Leemans IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy Impact: The individualized Functionnectome framework applies the precision medicine paradigm to radiomics, by using brain connectivity maps conformant to each patient’s unique anatomy, thereby ensuring accurate projection in cases with disrupted structures, e.g., due to tumors.
14:21		Screen Number: 19 0213. Spatiotemporal Activation Mapping for Enhanced Neural Activity Detection in Direct Imaging of Neuronal Activity (DIANA) fMRI View Presentation Video J-Y Keum, P. T. Toi, S. Park, H. Chun, J-Y Park Sungkyunkwan University, Suwon, Korea, Republic of Impact: Spatiotemporal activation mapping is expected to enhance our understanding of sensory information processing across the brain, by enabling DIANA fMRI to detect specific brain activation areas, ultimately contributing to realistic modeling of dynamic brain networks at the neural circuit level.
14:23		Screen Number: 20 0214. Heterogeneous lifespan development of functional networks in major depression and its association with clinical and gene expression profiles View Presentation Video C. Pang, X. Sun, X. Wang, D. Wei, Y. Chen, B. Liu, C-C Huang, Y. Zheng, Y. Wu, T. Chen, Y. Cheng, X. Xu, Q. Gong, T. Si, S. Qiu, C-P Lin, J. Cheng, Y. Tang, F. Wang, J. Qiu, P. Xie, L. Li, Y. He, M. Xia Beijing Normal University, Beijing, China Impact: Our results highlight the heterogeneity of neurodevelopment in depression and suggest potential underlying molecular mechanisms, providing deeper insights into the disorder’s progression and supporting the identification of biomarkers for precise diagnosis and treatment.
14:25		Screen Number: 21 0215. Progression of visual-stimulus-evoked blood velocity response timing across individual arteries and veins measured with phase-contrast fMRA View Presentation Video Z. Hu, S. Proulx, D. Varadarajan, D. Gomez, S. Bollmann, J. Polimeni Massachusetts General Hospital, Charlestown, United States Impact: We measured neuronal activity-induced blood velocity responses across several stages of the macrovasculature. The mismatches in arterial and venous hemodynamic response timing can provide insight into tissue/microvascular hemodynamics, such as microvascular blood volume changes with activation.
14:27		Screen Number: 22 0216. Linking Brain Functional Connectivity of Older Adults to Maximum Voluntary Contraction: Towards a Neural Marker of Motor Strength View Presentation Video A. Ghaffari, V. Masjedizadeh, X. Chen, J. Langley, A. Seitz, M. Peters, W. Zhang, I. Bennett, X. Hu University of California, Riverside, Riverside, United States Impact: Older adults tend to experience impaired motor functions due to aging or certain diseases. Here, we determined the most crucial functional connections assessing the motor abilities of older adults which could be used as the targets for their rehabilitation programs.
14:29		Screen Number: 23 0217. The Role of Neuroplasticity in Pain and Fear of Re-Injury Following ACL Reconstruction View Presentation Video Y. Zhang, G. Yang, X. Zeng, S. Pan, C. Li, C. Qian, H. Wang Fudan University, Shanghai, China Impact: The study reveals that peripheral nociceptive input alters brain structure and function in ACLR patients, emphasizing the critical need for targeted neuropsychological interventions alongside comprehensive physical rehabilitation to improve pain management and return-to-sport success.
14:31		Screen Number: 24 0218. State-transition fMRI between anesthetized and awake mice View Presentation Video D. Hike, X. Liu, X. Zhou, A. Smith, N. Pasupathy, C. Lin, Y. Jiang, A. Devor, X. Yu Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, United States Impact: Distinct brain regions along reticular ascending pathways can be directly identified by analyzing the spectral-specific rs-fMRI signal changes that occur as animals transition into and out of anesthetized states. This work opens a new avenue for consciousness studies in rodents.
14:33		Screen Number: 25 0219. Resting-State Functional Electrical Properties Tomography (rsfEPT) View Presentation Video J. Luo, K. Shmueli University College London, London, United Kingdom Impact: We demonstrated rsfEPT for the first time using ICA. In addition to elucidating potential contributions to task-based fEPT, both neurophysiological and noisy or artifactual, this rsfEPT technique opens the possibility to reveal new conductivity-based resting-state networks in the human brain.

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