ISMRM25 - Structure-Function Relations in MSK

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Structure-Function Relations in MSK

Power Pitch

Musculoskeletal

Wednesday, 14 May 2025

Power Pitch Theatre 2

13:30 - 15:30

Moderators: JeongAh Ryu & Suraj Serai

Session Number: PP-14

No CME/CE Credit

13:30		Screen Number: 26 0962. Patellar Metabolic and Compositional Markers from 18NaF PET/MRI are associated with Whole Organ Magnetic Resonance Imaging Scores and OA-status View Presentation Video R. Bhattacharjee, V. Kreutzinger, Z. Akkaya, K. Ziegeler, E. Bahroos, M. Han, V. Pedoia, R. Souza, S. Majumdar University of California, San Francisco (UCSF), San Francisco, United States Impact: Presence and extent of morphological bone-marrow-edema, subchondral-cyst, and cartilage-lesion in the patella, and their relationship with peak SUV,T_1p, and T₂ in patellar subregions in multiple OA subgroups can help elucidate bone remodeling, cartilage degradation and their manifestation in radiographic signs.
13:32		Screen Number: 27 0963. The Aging Knee: Changes in Bone Metabolic Activity & Cartilage T2 Relaxation Times Measured Using [18F] NaF PET-MRI View Presentation Video A. Goyal, Y. Vainberg, R. Shalit, J. Asay, L. Watkins, A. Gatti, Y. S. Song, B. Haddock, F. Kogan Stanford University, Stanford, United States Impact: This study demonstrates the potential of a functional [18F]NaF PET-MRI ‘stress test’ for joint health, offering region-specific joint biomarkers. This work emphasizes the role of PET-MRI in improving understanding of how aging-related changes in the joint contribute to osteoarthritis.
13:34		Screen Number: 28 0964. Entheseal bone remodeling in the anterior patella is associated with worse functional knee outcomes – new insights from [18F]NaF-PET MRI View Presentation Video K. Ziegeler, V. Kreutzinger, R. Bhattacharjee, E. Hammond, E. Bahroos, Z. Akkaya, T. Link, R. Souza, S. Majumdar University of California San Francisco, San Francisco, United States Impact: Bone remodeling at the enthesis of the patellar tendon quantified by [18F]-NaF PET-MRI is related to pain and other patient reported outcomes and may offer inroads to understanding the poor correlation between structural lesions and symptoms in OA.
13:36		Screen Number: 29 0965. T2 Texture Analysis of Knee Cartilage in Healthy Individuals: Impact of Regular Running and Demographics View Presentation Video V. Ghodrati, D. Vilimek, J. Uchytil, D. Jandacka, M. T Nieminen, V. Casula Research Unit of Health Sciences and Technology, University of Oulu, Oulu, FINLAND, Oulu, Finland Impact: These results may advance machine learning models using non-invasive T2 texture analysis to identify osteoarthritis risk, promoting research into preventive strategies and enhancing monitoring and early interventions for joint health through improved understanding of cartilage changes.
13:38		Screen Number: 30 0966. Subregion-Specific T2-Cluster Analysis Reveals Early Cartilage Changes in Anterior Cruciate Ligament Reconstructed Knees View Presentation Video V. Barriobero, M. Black, K. Young, J. Asay, S. Sherman, F. Kogan, G. Gold, B. Hargreaves, A. Chaudhari, A. Gatti, A. Pai S Harvard University, Cambridge, United States Impact: T2-clusters are better at detecting spatiotemporal variations in T2 within femoral cartilage subregions compared to bulk mean T2. T2-clusters are consistent with patterns of full-thickness defects observed in osteoarthritic cartilage, suggesting its potential application in monitoring cartilage health post-ACLR.
13:40		Screen Number: 31 0967. 3D T2* Mapping of Articular Cartilage at 7 Tesla in Patients Before and After Medial Meniscus Posterior Root Tear Repair View Presentation Video K. Knutsen, C. Steinberger, E. Hedayati, A. Lamba, S. Zbyn, L. Tollefson, T. Takahashi, G. Metzger, R. LaPrade, A. Kajabi, J. Ellermann University of Minnesota , Minneapolis , United States Impact: Post-operative monitoring of articular cartilage with 3D T2* mapping at 7T, which benefits from an enhanced signal-to-noise ratio, provides valuable insights into healing progression, guides timely treatments and potentially helps prevent osteoarthritis.
13:42		Screen Number: 32 0968. Positive Effect of Weight Loss on Knee Articular Cartilage – a Three-year Follow-up Using Texture Analysis of T2 Relaxation Time Maps View Presentation Video E. Mäkelä, V. Casula, A. Kemppainen, M. Haapea, M. Nieminen University of Oulu, Oulu, Finland Impact: The results support prior evidence for the benefits of weight loss for cartilage health and are important in the context of osteoarthritis prevention and treatment.
13:44		Screen Number: 33 0969. QSM of epiphyseal cartilage neovascularization following femoral head ischemia: a retrospective 9.4T piglet model study View Presentation Video A. Shekarabi, E. Buko, S. Parvaze Pathan, C. Johnson University of Minnesota, Minneapolis, United States Impact: This work demonstrates improved visualization and characterization of neovascularization following ischemic injury and revascularization of epiphyseal cartilage using the recently described QSM processing pipeline. This tool may be useful for studying the pathogenesis of LCPD and related developmental joint disorders.
13:46		Screen Number: 34 0970. Quantitative Assessment of Patellar Tendon Recovery and Anterior Cruciate Ligament Graft Quality using Bi-exponential UTE-T1ρ Mapping View Presentation Video H. Lise de Moura, M. Keerthivasan, P. Su, G. Koerzdoerfer, M. Alaia, R. Regatte NYU Langone Health, New York, United States Impact: The sequence demonstrates potential as a tool for assessing maturity of ACL grafts. It can help understand the recovery of PT, the quality of ACL reconstruction, and risk of post-traumatic osteoarthritis. This knowledge could improve surgical techniques and rehabilitation protocols.
13:48		Screen Number: 35 0971. Gait influences changes in T2 clusters in an ACL reconstructed population 2-3 years post-surgery View Presentation Video J. Asay, A. Pai S, J. He, A. Williams, G. Gold, A. Gatti, B. Hargreaves, C. Chu Stanford University, Stanford, United States Impact: T₂-cluster analysis combined with biomechanics may offer new insights into early cartilage focal changes in areas of loading that could otherwise be missed using the standard average regional T₂ relaxation times, potentially providing target areas for future therapeutics.
13:50		Screen Number: 36 0972. Quantitative UTE Imaging of the Meniscus Across Different Zones: A Study on Knee Osteoarthritis View Presentation Video A. Suprana, H. D. Chae, M. Daskareh, S. H. Shin, J. Athertya, R. Sah, E. Chang, J. Du, Y. Ma University of California, San Diego, La Jolla, United States Impact: This study, to our knowledge is the first to employ UTE-T1, UTE-MT modeling, UTE-AdiabT1ρ, and UTE-T2*to investigate compositional changes of each of the 3 vascular zones of the meniscus due to osteoarthritis.
13:52		Screen Number: 37 0973. Time-resolved 3D-PC MRI measurements of the upper leg muscles during dynamic knee flexion: the effect of the fatigue threshold View Presentation Video L. Vos, S. Rauh, H. Kan, A. Nederveen, G. Strijkers, M. Hooijmans Amsterdam UMC, Amsterdam, Netherlands Impact: Exercising slightly above the fatigue threshold does not impact 3D PC-MRI derived FH velocity data for the hamstring muscles compared to below-threshold levels, suggesting that muscle fatigue may have limited effect. However, further analysis of strain-rate and strain are required.
13:54		Screen Number: 38 0974. Microstructure and muscle strength in older adults: a time-dependent diffusion study View Presentation Video V. Mazzoli, S. Rao, D. Long, S. Kadam, G. Lemberskiy, T. Feiweier, G. Koerzdoerfer, D. Novikov, E. Fieremans, S. Coelho NYU Langone, New York, United States Impact: The apparent diameter a, obtained by modeling time-dependent diffusion data combined with RPBM modeling, is strongly associated to muscle strength in older adults, and is therefore a promising tool to study early signs of muscle atrophy and sarcopenia.
13:56		Screen Number: 39 0975. IDEAL-IQ and BOLD MRI Assessment of Testosterone and Resistance Training Effects on Fat Infiltration and Blood Perfusion in Sarcopenic Rats View Presentation Video X. kui, X. Huang, Y. Huang, L. Nie, B. He The First Affiliated Hospital of Kunming Medical University, Kunming, China, China Impact: This combined RT and T treatment demonstrates a potential therapeutic approach for sarcopenia, effectively enhancing muscle structure and function. IDEAL-IQ and BOLD MRI offer reliable, noninvasive methods for tracking these muscle changes in research and clinical settings.
13:58		Screen Number: 40 0976. Investigation of the feasibility of CEST MRI in early detecting diabetic muscle injuries in a rabbit model at 5 T View Presentation Video Q. Wu, Z. Huang, H. Tang, Y. Wu Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong , China Impact: The significantly increased Cr and reduced PCr/Cr occurred before structural alterations, suggesting the feasibility of CEST MRI in early detecting diabetic muscle damage at the energy metabolism level.
14:00		Screen Number: 41 0977. Hamstring Muscle Architecture and Microstructure Changes Following 9-weeks of Nordic Hamstring Exercise Training View Presentation Video A. Pai S, M. Andrews, R. Gurchiek, P. Pincheira, M. Barbieri, T. Friedrich, F. Kogan, G. Gold, G. Lichtwark, V. Mazzoli, S. Delp, A. Chaudhari Stanford University, Stanford, United States Impact: This study examines architectural and microstructural adaptations of the hamstrings following 9-weeks of Nordic hamstring exercise training. Findings reveal significant, but non-uniform hypertrophy among hamstrings accompanied by increase in length and size of the muscle fibers, advancing injury prevention strategies.
14:02		Screen Number: 42 0978. Development of an open-source, MRI-compatible grip force sensor for dynamic muscle MRI View Presentation Video S. Räuber, M. Maggioni, P. Panos, F. Santini University of Basel, Allschwil, Switzerland Impact: The low-cost, open-source grip force sensor demonstrated excellent MRI compatibility and therefore appears to be suitable for use with dynamic muscle MRI methods to characterise forearm flexors, with potential applications in the study of myotonic dystrophy.
14:04		Screen Number: 43 0979. Repeatability and sensitivity of the skeletal muscle response to in-scanner isometric exercise with vPIVOT MRI View Presentation Video E. Englund, J. Reusch, A. Barker University of Colorado, Anschutz Medical Campus, Aurora, United States Impact: Dynamic measurement of skeletal muscle perfusion in response to in-scanner exercise with vPIVOT MRI was repeatable and sensitive to varied exercise intensity in healthy adults. These results will help to facilitate comparison in future studies of patient populations.
14:06		Screen Number: 44 0980. Relationship between function and MRI biomarkers in tongue muscles View Presentation Video E. Vermeulen, P-Y Baudin, Y. Fromes, B. Matot, E. Giacomini, M. Lapert, J-Y Hogrel, B. Marty Institute of Myology, Paris, France Impact: The use of quantitative fat fraction and water T2 imaging in tongue muscles in addition to functional testing represents a promising approach for evaluating these muscles.
14:08		Screen Number: 45 0981. Multifidus muscle mitochondria function in those with non-specific chronic low back pain View Presentation Video D. Cawley, S. Adnani, A. Tickal, T. Denney, A. Bashir Edward Via College of Osteopathic Medicine, Auburn, United States Impact: We, for the first time, demonstrated the application of 31P MRS for measurement of mitochondrial function in lumbar multifidus muscle. Impaired ATP production in weak/underused multifidus muscle might be early markers of unspecified lower back pain.
14:10		Screen Number: 46 0982. 4D Time-Resolved Strain Tensor Analysis Using Spectro-Dynamic MRI Reveals Muscle Activation Patterns View Presentation Video M. van Riel, D. Heesterbeek, R. Sheombarsing, M. Froeling, T. van Leeuwen, C. van den Berg, A. Sbrizzi UMC Utrecht, Utrecht, Netherlands Impact: Time-resolved 4D strain analysis using Spectro-Dynamic MRI enables the measurement of in vivo biomechanics in a dynamic setting. This creates an opportunity for new ways to investigate the functioning and performance of active muscles.
14:12		Screen Number: 47 0983. Investigating Forearm Muscle Adaptations in Hemiparetic Cerebral Palsy Using Diffusion MRI: Structural Correlates of Grip Strength Deficits View Presentation Video D. Joshi, A. Hruby, J. Dewald, C. Ingo Northwestern University, Evanston, United States Impact: Decreased muscle volume and altered microstructure, as indicated by reduced diffusivity, contribute to functional impairments in HCP. DTI-based diffusivity metrics non-invasively reveal crucial insights into pathophysiological changes in muscle tissue, such as muscle atrophy and fibrosis.
14:14		Screen Number: 48 0984. Ultrashort Echo Time Magnetization Transfer Imaging of Lumbar Nerve Roots: A Study of Low Back Pain J. Liu, Y. Lu, Y. Ma Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Impact: UTE-MT is a promising technique for evaluating the compositional changes of compressed nerve roots in lumbar radiculopathy and their relationship with LBP.
14:16		Screen Number: 49 0985. Nested Habitat Analysis Based on MRI for Prediction of Progression-Free Survival in Aggressive Spinal Tumors View Presentation Video Y. Zhang, Q. Wang, T. Wang, Y. Chen, R. Yan, K. Liu, W. Zhao, D. Hao, M-Y Su, N. Lang University of California, Irvine, United States Impact: This study's MRI-based nested habitat radiomics model enhances prediction accuracy of progression-free survival (PFS) in aggressive spinal tumors by focusing on the most aggressive regions, outperforming traditional models and providing valuable insights for personalized surgical and post-surgical treatment strategies.
14:18		Screen Number: 50 0986. Long-term monitoring bone porosity in vivo T1DM Rabbits using UTE-MRI k. wang, W. Liu, H. Lei, R. Yang, Y. Zha Department of Radiology, Renmin Hospital of Wuhan University, wuhan, China Impact: UTE-MRI is feasible to assess cortical bone porosity and geometry in T1DM, offering a non-invasive, radiation-free method to evaluate bone health. This technique supports fracture evaluation and management guideline in diabetic patients, improving clinical outcomes.

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