ISMRM25 - Stroke & Blood Vessels: Novel Techniques & Applications

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Stroke & Blood Vessels: Novel Techniques & Applications

Power Pitch

Neuro

Thursday, 15 May 2025

Power Pitch Theatre 2

08:15 - 10:15

Moderators: Zhaoyang Fan & Masahiro Ida

Session Number: PP-16

No CME/CE Credit

08:15		Screen Number: 26 1209. Quantitative characteristics of carotid perivascular adipose tissue measured by MR imaging: Potential indicators for ischemic stroke risk View Presentation Video S. Yu, R. Huo, X. Chen, X. Lin, X. Song, H. Qiao, Z. Ning, D. Meng, N. Xu, Z. Lin, Y. Liu, X. Zhao Tsinghua University, Beijing, China Impact: Our study demonstrated that the amount of PVAT in carotid artery with vulnerable plaques is independently associated with cerebral infarction, suggesting that greater PVAT amount may indicate higher risk of ischemic stroke.
08:15		Screen Number: 27 1210. Simultaneous Gadolinium-free MR Angiography, Venography and Relaxometry using a fast 3D MR-STAT protocol View Presentation Video M. Schilder, S. Mandija, H. Liu, E. Versteeg, M. Fuderer, O. van der Heide, M. Haacke, T. Meerbothe, T. Snijders, P. Robe, C. van den Berg, A. Sbrizzi University Medical Center Utrecht, Utrecht, Netherlands Impact: In addition to fast, high-resolution multiparametric mapping, MR-STAT offers gadolinium-free MRA and MRV without the need of additional scan time, reducing the burden of contrast injections and dispensing with environmentally harmful and expensive gadolinium-based contrast agents.
08:15		Screen Number: 28 1211. SNAPFLOW: A Novel Integrated MRI Sequence for Simultaneous Cerebral MRA and Blood Flow Assessment View Presentation Video Z. Han, Z. Li, P. Wu, X. Liu, Z. Chen, X. Zhao Tsinghua University, Beijing, China Impact: The novel sequence SNAPFLOW enables simultaneous acquisition of MRA and blood flow data within a single scan, offering an efficient and comprehensive cerebrovascular assessment. In addition, this proposed sequence has potential in evaluating intraplaque hemorrhage.
08:15		Screen Number: 29 1212. Highly Accelerated 3D TOF MRA using Deep Learning Reconstruction with Raw K-space Simulation View Presentation Video H. Li, M. Chiew, I. Dragonu, P. Jezzard, T. Okell University of Oxford, Oxford, United Kingdom Impact: The proposed method shows promise for highly accelerating 3D-TOF-MRA due to its superior performance. Overcoming data scarcity, this approach holds the potential for advancing research and clinical applications of high-resolution whole-head 3D-TOF-MRA imaging, enhancing cerebrovascular diagnostics.
08:15		Screen Number: 30 1213. Sex-Based Differences in Vasodilatory Flow Capacity Measured with 4D Flow MRI and White Matter Disease Burden Among PWH: A Preliminary Study View Presentation Video N. Konovalova, B. Fong, E. Kao, J. Schollenberger, M. Wilson, J. Liu, S. Wang, Y. Yu, F. Chow, J. Narvid, D. Saloner University of California, San Francisco, San Francisco, United States Impact: Our findings underscore the need for sex-specific studies in cerebrovascular health for PWH, potentially guiding targeted interventions for neurovascular and cognitive health. Further research in larger cohorts could validate these preliminary observations and clarify their clinical implications.
08:15		Screen Number: 31 1214. A multi-software and multi-vendor cross-comparison study of intracranial 4D flow MRI data analysis View Presentation Video Y. Wang, M. Luo, R. Li, B. Sui, J. Tang Sichuan Provincial People's Hospital, Chengdu, China Impact: It reveals that flow measurements of intracranial arteries from different scanners showed better agreement than that processed by different software. This may set a reference to compare results by different pipelines and guide the multi-center study design of 4D flow.
08:15		Screen Number: 32 1215. Fully Automated Segmentation and Hemodynamic Quantification of Carotid Artery 4D Flow MRI View Presentation Video E. Johnson, H. Berhane, J. Andrae, C. Strecker, H. Mast, H. Urbach, M. Markl, A. Harloff Northwestern University, Chicago, United States Impact: This study demonstrated a method for automatically generating segmentations of the carotid vessels in 4D flow MR images and quantifying hemodynamics. It can inform efforts to reproducibly study carotid hemodynamics in large cohorts of subjects.
08:15		Screen Number: 33 1216. Evaluating Segmentation Techniques for Circle of Willis in 4D Flow MRI: A Comparative Study View Presentation Video J. Zhang, A. Verschuur, E. Schrauben, M. Bakker, P. Ooij, K. M. Nam, I. Schaaf, C. Tax University Medical Center Utrecht, Utrecht, Netherlands Impact: Accurate automatic intracranial vessel segmentation methods decrease the need for manual intervention and facilitate the measurement of flow in smaller arteries.
08:15		Screen Number: 34 1217. Associations of lenticulostriate artery geometry and hemodynamics with age, vascular risks, and cognitive decline: A high-resolution 7T study. View Presentation Video J. Tang, T. Tanji, M. Anukwu, T. Zhao, E. Joe, H. Chui, L. Yan Northwestern University, Chicago, United States Impact: 7T high-resolution MRI including dual-VENC PC-MRI and 3D TOF provide comprehensive assessment of LSA geometry and flow dynamics, offering a class of sensitive imaging biomarkers for small vessel disease and cognitive impairment, and providing valuable insights into SVD pathology.
08:15		Screen Number: 35 1218. Utilizing Blood Clots as Intrinsic Contrast Agents in Postmortem Vascular MRI at 7T View Presentation Video C. Li, H. Pang, Z. Sun, M. Zhang, L. Jiang, A. Li, D. Leitner, T. Wisniewski, A. Faustin, O. Devinsky, M. Bruno, Y. Wadghiri, J. Zhang, Y. Ge New York University Grossman School of Medicine, New York, United States Impact: The imaging characteristics of postmortem blood clots on T2*-W MRI enable detailed mapping of brain small vessel architecture, with contrast similar to in vivo Ferumoxytol-enhanced imaging, offering a novel method to study postmortem vasculature and imaging correlates to vascular pathology.
08:15		Screen Number: 36 1219. The reactivity penumbra as a novel metric of ischemic symptomatology in patients with intracranial cerebrovascular disease View Presentation Video C. Han, W. Richerson, M. Garza, M. Leguizamon, M. Mishra, L. Davis, M. Fusco, R. Chitale, L. Jordan, M. Donahue Vanderbilt University Medical Center, Nashville, United States Impact: Cerebrovascular reactivity (CVR) metrics, assessed from fixed-inspired hypercapnic stimuli, differ in brain hemispheres with versus without recent ischemic symptoms; furthermore, the volume of CVR impairment, relative to asymptomatic hemispheres, and the CVR measurements themselves are related to recent ischemic symptomatology.
08:15		Screen Number: 37 1220. Cerebrovascular Reactivity Response Times Following Revascularization Surgery in Patients with Moyamoya View Presentation Video W. Richerson, A. Bhogal, C. Han, M. Garza, A. Song, M. Fusco, R. Chitale, L. Jordan, M. Donahue Vanderbilt University Medical Center, Nashville, United States Impact: Cerebrovascular reactivity (CVR) response times in both time-shifted and exponential models were significantly decreased in response to revascularization surgery in moyamoya patients, motivating the utilization of CVR response times as a biomarker to evaluate treatment in moyamoya disease.
08:15		Screen Number: 38 1221. Comparison of CNR in vessel wall imaging using compressed sensing in vertebral arteries View Presentation Video T. Hiraka, Y. Sugai, T. Ogasawara, K. Haga, M. Kanoto Yamagata University Faculty of Medicine, Yamagata, Japan Impact: CS may lead to a deterioration in the visibility of vertebral arteries for VWI in the posterior fossa. Although CS has potential benefits, careful adjustment of imaging parameters is necessary to mitigate the negative effects, especially when evaluating vertebral arteries.
08:15		Screen Number: 39 1222. Reliable and repeatable derived cerebrovascular metrics using 2Hz DSC MRI at 3T and 7T View Presentation Video D. Schwartz, E. Baker, B. Moloney, X. Li, O. Huerta, F. Lesage, A. Linninger, W. Rooney Oregon Health & Science University, Portland, United States Impact: This high temporal and spatial resolution method is easily accessible and precludes the necessity of using commonly derived "relative" metrics; absolute metrics make effortless the translation and comparison of derived cerebrovascular qualities across diseases, studies, individuals, and the brain.
08:15		Screen Number: 40 1223. Combined Luminal and Hemodynamic Nonenhanced Neck MR Angiography Using an Efficient Tilted Multiple Thin-Overlapping-Slab Strategy View Presentation Video I. Koktzoglou, O. Ozturk, Z. Bulwa, F. Gil, W. Ares, E. Azizi, N. Leloudas, R. Edelman Endeavor Health, Evanston, United States Impact: The provision of high-quality luminal and hemodynamic data in a single and efficient nonenhanced MRA protocol may help to reduce costs, enhance our ability to evaluate the hemodynamic impact of cervical arterial disease, and inform clinical decision-making.
08:15		Screen Number: 41 1224. Whole-cerebrum three-dimensional pseudo-continuous arterial spin labeling at 5T: reproducibility and preliminary application in moyamoya View Presentation Video Z. Li, X. Fan, G. Han, H. You, J. Ni, M. Li, F. Feng Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing, China Impact: Whole-Cerebrum PCASL imaging at 5T ultra-high field offers a promising tool in the assessment of hemodynamic conditions in cerebrovascular diseases.
08:15		Screen Number: 42 1225. Aneurysm Wall Permeability Measured by DCE-MRI as a Predictor of Growth in Non-Saccular Intracranial Aneurysms at Follow-up View Presentation Video Y. Li, Z. Xu, L. Dong, Y. Wang, P. Liu, M. Lv, H. Chen Center for Biomedical Imaging Research, Tsinghua University , Beijing, China Impact: This study demonstrates that baseline K^trans, derived from DCE-MRI, is an effective predictor of non-saccular intracranial aneurysm growth. It offers a valuable tool for predicting aneurysm growth and enhancing rupture risk prediction in clinical practice.
08:15		Screen Number: 43 1226. Artificial Intelligence to Eliminate the Need for Gadolinium-Based Contrast Agents in Brain Perfusion Weighted Imaging A. Cao, Y. Zhang, Y. Kang, J. Guo Shenzhen University, Shenzhen, China Impact: AI-generated hemodynamic parameters from non-contrast imaging offer significant clinical benefits, including reduced costs, faster acquisition, and improved patient safety. This approach could streamline stroke diagnosis and improve healthcare accessibility.
08:15		Screen Number: 44 1227. Assessment of Longitudinal Neurometabolic and Neurotransmitter Changes in Ischemic Stroke with Ultrafast J-Resolved MRSI View Presentation Video T. Wang, B. Bo, Z. Meng, C. Xu, Y. Zhao, Y. Li, W. Jin, J. Wang, Z. Chen, Z-P Liang, Y. Li Renji Hospital, Shanghai Jiao Tong University of Medicine, shanghai, China Impact: Ultrafast J-resolved MRSI enables high-resolution mapping of metabolites and neurotransmitters within 11 minutes, offering valuable insights into tissue viability in ischemic stroke patients during longitudinal assessments.
08:15		Screen Number: 45 1228. Microstructural Brain Changes and Their Impact on Motor and Cognitive Functions After Hemorrhagic Stroke: A NODDI-Based Study View Presentation Video H. Li, S. Wang, Y. Zhang, X. Wang, X. Zhao, L. Chen, M. Yuan, Z. Chen, H. Wang, Y. Ju, S. Sun Fudan University, Shanghai, China Impact: Early stage of ICH may result in the disruption of microstructural integrity within brain tissue.
08:15		Screen Number: 46 1229. Prediction of Long-term Motor Function Based on integrity of corticospinal tract in Ischemic Stroke after Intra-arterial Thrombectomy View Presentation Video B-F Lin, W. Yang, Y-J Lai, T-Y Lu, S-L Peng, C-F Lu China Medical University, Taichung, Taiwan Impact: Early white matter integrity after IAT treatment can predict long-term motor function in ischemic stroke patients.
08:15		Screen Number: 47 1230. Application of DTI and Resting State fMRI in Clinical Trial of Neural Stem Cells (NR1) Intracerebral Transplantation for Chronic Ischemic Stroke View Presentation Video B. Jiang, D. Kim, T. Liang, G. Zaharchuk, M. Zeineh, G. Steinberg Stanford University, Stanford, United States Impact: Monitoring neuroimaging changes may facilitate patient selection and predict both short- and long-term responses to cell therapy. Further data collection and molecular analysis are necessary to deepen our understanding of brain changes following stem cell therapy.
08:15		Screen Number: 48 1231. Quality control algorithm for resting-state BOLD based cerebrovascular reactivity mapping View Presentation Video Y. Wang, P. Liu, H. Lu, D. Wu, Z. Lin Zhejiang University, Hangzhou, China Impact: This work proposed an automatic, objective and quantitative method for quality control of resting-state CVR mapping.
08:15		Screen Number: 49 1232. Evaluation of Cerebrovascular Reactivity Damage Using Resting-State BOLD in Symptomatic Patients with Unilateral MCA/ICA Occlusion View Presentation Video Y. Shan, Y. Yin, B. Cui, B. Xu, J. Lu Xuanwu Hospital, Capital Medical University, Beijing, China Impact: This study proposes a new hemodynamic marker (CVR-AI) for risk stratification in patients with unilateral intracranial arterial occlusion and promotes the feasibility of measuring CVR using RS BOLD.
08:15		Screen Number: 50 1233. Magnetic resonance angiography for the prediction of carotid atherosclerotic plaque formation N. Han, J. Zhang, K. Ai Lanzhou University Second Hospital, Lanzhou, China Impact: Ischemic stroke has high incidence, disability and mortality rate that is often caused by carotid plaques. Variations in carotid geometry impact local hemodynamics, influencing atherosclerotic plaque formation. 4D flow MRI and 3D TOF-MRA provide a non-invasive, quantitative assessment of these characteristics.

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