ISMRM25 - Biomarkers of Neurodegeneration

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Biomarkers of Neurodegeneration

Power Pitch

Neuro

Tuesday, 13 May 2025

Power Pitch Theatre 1

13:30 - 15:30

Moderators: Quy Cao & Yun Jiang

Session Number: PP-17

No CME/CE Credit

13:30		Screen Number: 1 0567. Neurometabolic Signatures of Cognitive Resilience in Alzheimer's Disease: A Hybrid 3D-MRSI/PET Study View Presentation Video W. Li, M. Zhang, Y. Zhao, Y. Li, W. Jin, Y. Zhang, J. Hu, Z-P Liang, Y. Li Shanghai Jiao Tong University, Shanghai, China Impact: Higher NAA/Cr and lower mI/Cr levels in the parietal and temporal lobes may serve as promising markers of CR in AD. These neurometabolic signatures may provide insights into intervention strategies aimed at slowing cognitive decline in AD.
13:32		Screen Number: 2 0568. Clinical validation of a multi-modal ultra-fast MRI protocol for dementia diagnosis View Presentation Video H. Chughtai, D. Thomas, M. Rosa-Grilo, C. Sudre, B. Solanky, E. Lim, D. Mallon, H. R. Jäger, L. Prosser, I. Malone, D. Alexander, F. Barkhof, N. Fox, C. Mummery, G. Parker University College London, London, United Kingdom Impact: By significantly decreasing scan time, our validated ultra-fast protocol enables wider access to MRI for patients with dementia, whilst maintaining diagnostic utility, reducing healthcare costs and improving the patient experience.
13:34		Screen Number: 3 0569. Mapping the Progressive Degeneration of the Olfactory Cortex from Normal Cognition to Alzheimer's Disease View Presentation Video C. GUO, S. YANG, Y. CAO, B. XIE, Z. SHEN, N. ZHENG, Y. YANG, H. ZHANG The First Hospital of Jilin University, Changchun, China Impact: These findings advance our understanding of hemispheric vulnerability in early neurodegeneration, offering potential insights for therapeutic intervention before widespread impairment occurs. The identified progression pattern may contribute to developing more sensitive early detection strategies in AD.
13:36		Screen Number: 4 0570. Impaired mitochondrial energy metabolism related to astrocyte in the brain of Alzheimer’s disease View Presentation Video M. Ono, K. Hirata, R. Kono, K. Saito, Y. Maeda, Y. Abe, M. Kawami, H. Shimizu, Y. Uchida, Y. Takado National Institutes for Quantum Science and Technology, Chiba, Japan Impact: This study provides insights into impaired mitochondrial energy metabolism associated with AD. Hyperpolarized [1-¹³C]pyruvate MRS detected hippocampal metabolic changes in AD mouse model at early pathological stages, and is expected to be applied to pathological studies of AD.
13:38		Screen Number: 5 0571. Altered Functional Connectivity of Cortical Networks and Hippocampus by Transcranial Alternating Current Stimulation in Alzheimer's Disease View Presentation Video T. Wang, S. Yan, H. Xue, J. Lu Xuanwu Hospital, Capital Medical University, Beijing, China Impact: fMRI has furnished a precise neuroimaging substrate for the efficacy assessment after tACS, helpful for neurologists to capture neuronal activity modifications. fMRI can elucidate the therapeutic variances and facilitate the refinement of individualized and targeted stimulation protocols for AD patients.
13:40		Screen Number: 6 0572. Characterization of cerebrovascular reactivity in aging, Alzheimer’s disease, and vascular dementia using multi-echo, multi-contrast MRI View Presentation Video E. Keeling, M. Bergamino, L. Ott, M. McElvogue, A. Burke, M. Sabbagh, N. Bakkar, A. Stokes Barrow Neurological Institute, Phoenix, United States Impact: Complementary assessments of CVR on total and microvascular scales may comprehensively inform on differences in vascular integrity between populations. The microvascular-weighted analysis was sensitive to changes in CVR between groups and may be specific to dementia-related pathology in the microvasculature.
13:42		Screen Number: 7 0573. Integrating Event-Based and Biophysical Models to Predict Individual Tau Progression in Alzheimer's Disease View Presentation Video R. Sandell, J. Torok, D. Ma, A. Raj UCSF, San Francisco, United States Impact: Our method can be applied to explore inter-subject heterogeneity of protein spread patterns across a range of neurodegenerative conditions, enabling the development of precision therapeutic treatments that target individuals’ unique pathology.
13:44		Screen Number: 8 0574. Perfusion Velocity in Temporal Lobe Decreases Prior to Its Change in Other Brain Regions in Alzheimer’s Disease View Presentation Video Y. Guo, T. Liu, Y. Li, G. C. Chiang, W. Huang, M. J. d. Leon, Y. Wang, F. Chen, L. Zhou Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China Impact: These findings suggest that the perfusion velocity in temporal lobe supplied by MCA has the earliest change among the whole brain regions, which may be an early biomarker for AD diagnosis and offer a therapeutical target.
13:46		Screen Number: 9 0575. Impact of Defacement on Deep Learning-based Amyloid Prediction with Multi-contrast MRI View Presentation Video D. Kim, J. A. Ottessen, A. Kumar, B. Ho, C. Young, E. Mormino, G. Zaharchuk Stanford University, Stanford, United States Impact: Defacing MRI scans for privacy inadvertently removes information that may aid amyloid PET positivity prediction, as shown by decreased model performance on defaced images compared to non-defaced ones.
13:48		Screen Number: 10 0576. Functional Relationship with MR Elastography Measures of Basal Ganglia Stiffness in Mild Cognitive Impairment View Presentation Video M. Kramer, A. Diano, K. Twohy, O. Bailey, L. Hiscox, M. Cohen, A. Lanzi, C. Martens, C. Johnson University of Delaware, Newark, United States Impact: Basal ganglia stiffness correlates with function in people with MCI. MCI subjects with higher stiffness than controls experience improved mechanical and functional measures following exercise intervention. The MCI diagnosis may have specific subtypes that have different potential for intervention success.
13:50		Screen Number: 11 0577. Clinical Validation of Motion-Informed 3D Deep Learning Reconstruction in Patients with Cognitive Impairment at 3T View Presentation Video S. Fujita, D. Polak, D. Nickel, D. Splitthoff, Y. Huang, N. Gil, S. Buathong, C-H Chiang, W-C Lo, B. Clifford, S. Cauley, J. Conklin, S. Huang Athinoula A. Martinos Center for Biomedical Imaging Center, Boston, United States Impact: Deep learning-based reconstruction with integrated retrospective motion correction produced high-quality 3D MPRAGE in patients with cognitive decline. With clinically feasible processing times and robust performance, this technique shows promise for a wide range of neuroimaging protocols.
13:52		Screen Number: 12 0578. Pathological Insights into Dementia with Lewy Bodies: The Role of Quantitative Susceptibility Mapping View Presentation Video G. Venturi, E. Capogna, L. Motta, L. Guidi, D. Braghittoni, L. Sambati, M. Mitolo, E. Cantoni, G. Sighinolfi, R. Lodi, C. Tonon IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy Impact: This study demonstrates the potential of quantitative QSM as a biomarker for DLB monitoring disease progression. By linking brain iron deposition to cognitive deficits, it paves the way for further research into the underlying mechanisms of DLB.
13:54		Screen Number: 13 0579. Enhancing Diagnostic Accuracy in Parkinson’s Disease: The Impact of Deep Learning- Based AI on Nigrosome 1 Imaging in Brain MRI View Presentation Video J. Park, B. Sohn Samsung Medical Center , Seoul , Korea, Republic of Impact: Deep learning-based AI improves the diagnostic accuracy of nigrosome 1 abnormalities on Susceptibility map-weighted imaging (SMwI) for Parkinson’s disease across all radiological experience levels, which may extend its role in clinical decision-making for PD diagnosis.
13:56		Screen Number: 14 0580. Exploring Neuromelanin's Significance: Comparative Insights from Advanced MRI Techniques for Diagnosing Early-Stage Parkinson's Disease View Presentation Video C. Y. Lim, Y. H. Roh, B. Sohn Samsung medical center, Seoul, Korea, Republic of Impact: Our study highlights NM imaging in the SN as a superior biomarker for early Parkinson’s disease diagnosis compared to other imaging methods, offering clinicians a more reliable diagnostic tool.
13:58		Screen Number: 15 0581. Assessing Neurometabolic Alterations, Glutathione Depletion and Iron Deposition in the Mesostriatal Pathway of Parkinson's Disease S. Yan, B. Duan, X. Zhang, N. Zheng, W. Zhu Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Impact: These findings offer valuable insights into the pathophysiology of PD and may inform future therapeutic strategies targeting metabolic and oxidative stress pathways.
14:00		Screen Number: 16 0582. Disrupted Excitatory-Inhibitory Balance in the Motor Cortex of Parkinson’s Disease: A 7T MRS Study at Rest and Motor Tasks View Presentation Video N. Wei, D. Su, Z. Zhang, Y. Park, D. Deelchand, G. Genovese, M. Marjanska, T. Feng, J. Jing, Z. Zhang Beijing Tiantan Hospital, Capital Medical University, Beijing, China Impact: This study highlights disrupted inhibitory-excitatory balance in PD, providing insights for targeted therapies to improve motor function. It also prompts further investigation into neurotransmitter regulation, potentially benefiting clinicians and researchers in PD treatment development.
14:02		Screen Number: 17 0583. Post-levodopa reduction of cerebellar Glx in Parkinson’s disease: Effect on tremor severity View Presentation Video S. Prasad, D. Deelchand, M. Kumar, R. Yadav, P. Pal, J. Saini National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India Impact: Cerebellar Glx drives tremor severity in PD, and dopaminergic medication mediated reduction leads to an improvement in tremor severity. These results provide the first evidence of cerebellar Glx involvement in PD, and open avenues for new therapeutic interventions.
14:04		Screen Number: 18 0584. Macromolecular Proton Fraction Mapping of Subcortical Nuclei in Patients with Parkinson's Disease View Presentation Video Y. Fujiwara, N. Sakae, Y. Hirakawa, H. Kumazoe, K. Miyamoto, H. Kan, M. Kitajima Kumamoto University, Kumamoto, Japan Impact: Decreased MPF may reflect neurodegeneration, while increased magnetic susceptibility suggests iron accumulation. Combining MPF and QSM measurements in subcortical nuclei could aid in diagnosing Parkinson's disease.
14:06		Screen Number: 19 0585. A Novel Approach in Parkinson’s Disease Assessment using Quantitative MRI for Neuromelanin, QSM and χ-Separation View Presentation Video M. Dittrich, A. Moussavi, R. Dadarwal, C. Riedel, S. Boretius DPZ, Göttingen, Germany Impact: Multiple studies have explored novel imaging approaches for Parkinson’s disease. Our MR protocol provides an effective, comprehensive multi-parametric approach to quantify neuromelanin loss, increased susceptibility, and changes in magnetization transfer, offering more precise quantitative biomarkers.
14:08		Screen Number: 20 0586. Whole Brain Rapid Eye Movement Sleep Behavior Disorder Susceptibility Atlas and Enabled Longitudinal Analysis View Presentation Video A. Roberts, C. Skudin, J. Li, T. Crewes, R. Gregory, P. Spincemaille, A. Dimov, T. Nguyen, A. Shtilbans, Y. Wang Cornell University, New York, United States Impact: A whole brain multi-contrast rapid eye movement sleep behavior disorder atlas is presented to facilitate automatic segmentation. Such segmentations are helpful for cross-sectional comparisons and longitudinal analysis in healthy volunteer, REM sleep behavior disorder and early-stage Parkinson’s disease populations.
14:10		Screen Number: 21 0587. Decreased iron deposition in ventral pallidum associated with analgesic dependence and relapse in medication-overuse headache View Presentation Video X. Xu, J. He, M. Zhou, X. Wu, K. Yang, M. Zhang, K. Liu Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China Impact: Our findings show excessive iron accumulation in subcortical areas correlates with increased migraine burden. VeP iron levels are linked to analgesic dependence and MOH relapse, emphasizing disrupted iron homeostasis in migraine pathology and its implications for treatment strategies.
14:12		Screen Number: 22 0588. Time-Dependent Diffusion MRI Reveals Smaller Cell Size with Stable Volume in Hippocampus and Amygdala during Chemotherapy X. Zhou, D. Shi, Y. Huang, T. Yin, D. Wu, H. Guo, J. Xu, D. Liu, J. Zhang Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China Impact: By combining Time-Dependent Diffusion MRI and 3D T1WI MRI, a decrease in cell sizes with unchanged volume of hippocampus and amygdala among breast cancer patients was identified with repeated measurements during neoadjuvant chemotherapy, aiding early diagnosis and treatment of chemo-brain.
14:14		Screen Number: 23 0589. Aqueduct pressure gradient quantified by MRI in hydrocephalus populations. View Presentation Video O. BALEDENT, P. LIU, Y. ATTEKEBLE, J. XIE, H. MONNIER, S. METANBOU, K. OWASHI, C. CAPEL University Hospital CHU Amiens, Amiens, France Impact: Studying aging healthy individuals, hydrocephalus patients without improvement after shunt, Alzheimer’s populations may reveal new biomarkers to improve diagnosis and patient selection for shunt surgery. Such investigations will deepen our knowledge of the physiopathology of ventricle dilation and CSF clearance.
14:16		Screen Number: 24 0590. Arterial spin labelling-based evaluation of cerebrovascular reserve impairment using a mathematical convolution model View Presentation Video M. Fahlström, J. Sousa, T. Svedung Wettervik, J. Berglund, P. Enblad, A. Lewén, J. Wikström Uppsala University, Uppsala, Sweden Impact: Flow dampening functions in conjunction with modelling of the cerebrovascular response after acetazolamide injection may be used as a clinical surrogate in patients with moyamoya disease. Further studies are warranted analysing longitudinal datasets and normal material.

Similar Session(s)