ISMRM25 - Imaging Neurofluids: From CSF to Lymphatics

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Imaging Neurofluids: From CSF to Lymphatics

Power Pitch

Neuro

Tuesday, 13 May 2025

Power Pitch Theatre 1

08:15 - 10:15

Moderators: Junko Kikuta & Zhiliang Wei

Session Number: PP-18

No CME/CE Credit

08:15		Screen Number: 1 0449. Diurnal regulation of cerebrospinal fluid flow dynamics assessed using cardiac-corrected phase-contrast magnetic resonance imaging View Presentation Video M. Leguizamon, K. Hett, M. Curtin, A. DuBois, A. Song, C. Han, M. Garza, P. Trujillo, C. McKnight, C. Considine, M. Donahue Vanderbilt University Medical Center, Nashville, United States Impact: This works provides new evidence in humans that CSF flow dynamics at the level of the cerebral aqueduct become more dynamic over the circadian rhythm of wakefulness, with a directionality similar to that observed with increasing age and neurodegeneration.
08:17		Screen Number: 2 0450. Neurofluid fluctuation analysis using dynamical network biomarker (DNB) MRI in idiopathic normal pressure hydrocephalus View Presentation Video M. Sakai, T. Miyati, N. Ohno, S. Saito, H. Kasai, M. Mase Kanazawa University, Kanazawa, Japan Impact: We establish the basis of DNB-MRI and its clinical application to iNPH. The dMRI-DNB index enables to assess fluctuation of the water molecule in the brain.
08:19		Screen Number: 3 0451. Formulation and Simulation of Low b-value DTI of Pseudorandom Flow in CSF View Presentation Video Y. Bito, H. Kameda, N. Fujima, N. Kinota, D. Kato, T. Fujii, H. Ochi, K. Ishizaka, K. Hirata, K. Kudo Hokkaido University, Sapporo, Japan Impact: Formulation of low-b DT map in relation to flow-velocity vector-field was derived, and simulation using the formula and computational fluid dynamics revealed remarkable features of pseudorandom flows, suggesting that it could help in understanding pseudorandom flow measured with low-b DTI.
08:21		Screen Number: 4 0452. Multi-delay 2D interslice saturation MRI for non-invasive flow mapping of CSF in optic nerve subarachnoid space View Presentation Video M. Kim, J-G Im, S. Baete, S-H Park Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of Impact: This study introduces a non-invasive MRI technique to measure CSF flow in the ONSAS for the first time, offering potential for early NTG diagnosis. Its compatibility with clinical settings could make it a safer, more accessible alternative to invasive methods.
08:23		Screen Number: 5 0453. Diffusion-weighted 2D cortical slice mapping to spatially resolve distinct neurofluid flow regimes View Presentation Video R. Carlson, J-P Galons, C. Howison, N. Williamson, M. Komlosh, A. Avram, P. Basser, E. Hutchinson University of Arizona, Tucson, United States Impact: The measurement of spatially resolved flow regimes using the novel technique of 2D cortical slice diffusion-weighted MRI has the potential to improve clinical assessments of CSF neurofluid dynamics in the glymphatic-lymphatic system.
08:25		Screen Number: 6 0454. Neurofluid dynamics along the optic nerve: Application of 3D interleaved stack-of-stars (iSoS) with Time-SLIP Spin Labeling View Presentation Video H. N. Jung, V. Malis, M. McDonald, M. Miyazaki Korea Univeristy Guro Hospital, Seoul, Korea, Republic of Impact: Proof of neurofluid dynamics along the optic nerve provides new insights into understanding the pathophysiology and treatment of neuro-ophthalmic disease, particularly those related to the glymphatic system.
08:27		Screen Number: 7 0455. The water exchange across the blood-CSF barrier in human choroid plexus detected by relaxation-exchange MRI (REXI) View Presentation Video X. Wu, S. Tan, Y. Zhang, B. Jiao, F. Jiang, Y. Han, Y-C Hsu, R. Xue, R. Bai State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Impact: Considering the growing importance of neurofluids and CP, REXI provides with a new and contrast-agent-free technique to measure the water exchange across BCSFB and serves as a promising neuroimaging tool for evaluating CP function in future clinical studies.
08:29		Screen Number: 8 0456. Modulating cerebrospinal fluid dynamics using pulsed photobiomodulation: the dose and skin-colour dependence View Presentation Video A. Motsenyat, X. Zhong, H. Lankveld, J. Chen, J. Chen Baycrest, Toronto, Canada Impact: Photobiomodulation (PBM) has shown to enhance glymphatic drainage by modulating CSF flow, but in a delivery and dose-dependent manner. The significant wavelength-frequency interactions and melanin effects demonstrate the need to optimize PBM delivery in different settings.
08:31		Screen Number: 9 0457. Simultaneous assessment of cerebral arterial, venous, and CSF flow dynamics using multiband dual-VENC phase-contrast MRI View Presentation Video J. Tang, Z. Li, T. Zhao, S. Chung, L. Yan Northwestern University, Chicago, United States Impact: MD-DV PC-MRI enables simultaneously assessing CSF, arterial, and venous dynamics at multiple segments in the brain within a short scan time, which could be a potentially useful MRI technique to study blood-neurofluid coupling in both cerebrovascular and neurodegenerative diseases.
08:33		Screen Number: 10 0458. Assessing Glymphatic Flow Modulation by Vasopressin and Relcovaptan Using Glymph-FIT: a Novel Approach with DCE-MRI View Presentation Video M. Zhang, E. Hamed, S. Majumdar, J. Mitchell, M. Gillette, B. Sutton University of Illinois at Urbana-Champaign, Urbana, United States Impact: This study introduces Glymph-FIT, a novel tool for accurately measuring very slow glymphatic flow dynamics. Findings suggest V1A antagonism with relcovaptan enhances glymphatic flow, potentially offering new therapeutic strategies to improve brain waste clearance and potentially mitigate neurodegenerative disease progression.
08:35		Screen Number: 11 0459. Age-related and sex-specific reduction in cerebral arterial-venous cardiac pulse delay in functional magnetic resonance imaging View Presentation Video A. Wright, T. Xu, J. Koo, Y. Zhao, Y. Tong, Q. Wen Indiana University School of Medicine, Indianapolis, United States Impact: This work introduces a novel fMRI-based measure of cerebral arterial-venous pulse delay, providing an alternative tool sensitive to changes in vascular compliance. With the widespread accessibility of fMRI, this approach has applications for researching biomechanical changes in neurological conditions.
08:37		Screen Number: 12 0460. Cholinergic basal forebrain deficit impairs BOLD-CSF coupling and glymphatic flux View Presentation Video K-H Chuang, Y. Xia, X. Zhou, Z. Li, L. Qian, E. Eeles, G. Ngiam, J. Fripp, E. Coulson University of Queensland, Brisbane, Australia Impact: As cholinergic neurodegeneration is an early feature of Alzheimer's disease, the cholinergic pathway could be a new diagnostic and treatment target for improving glymphatic function in aging and dementia.
08:39		Screen Number: 13 0461. Glymphatic Dysfunction Correlate with Spatial Navigation Deficits in Subjective Cognitive Decline: Insights from 5.0T MRI View Presentation Video f. chen, L. zou, X. Fan, G. Cheng, Y. Li, B. Zhang The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China Impact: Our study is the first successful attempt in DTI-ALPS on 5T MRI datasets. The study found impaired glymphatic function in SCD may underlie early spatial navigation deficits, indicating a preclinical stage of AD.
08:41		Screen Number: 14 0462. Coupling between CSF inflow and ventricle volume change View Presentation Video H. Cheng, D. Kennedy Indiana University, Bloomington, United States Impact: This discovery not only provides an alternative method for characterizing CSF dynamics but also offers new insights into the origin of the global BOLD signal change and the complex and dynamic properties of components of the glymphatic system.
08:43		Screen Number: 15 0463. Comparison of Water Exchange Rate in Young and Elderly Adults with Diffusion Prepared and Multi-Echo Arterial Spin Labeling MRI View Presentation Video Y. Zhu, A. Bhattarai, B. Albuhwailah, X. Shao, J. Petr, K. Eickel, M. Günther, D. Wang, A. Fan University of California, Davis, Davis, United States Impact: Our study provides novel biological information about water exchange rate (Kw) in different brain regions to understand aging-related changes in blood-brain barrier physiology and advances the understanding of how Kw imaging measures differ between arterial spin labeling methods.
08:45		Screen Number: 16 0464. Assessing Glymphatic Dynamics in the Human Brain Using Cardiac-Gated diffusion MRI at Ultra-High Field View Presentation Video I. Aslam, T. Pavan, A. Spencer, R. Martuzzi, F. Ribaldi, G. Frisoni, I. Jelescu Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) Lausanne, Lausanne , Switzerland Impact: This study shows how glymphatic flow quantification using diffusion MRI in the human brain is influenced by the cardiac cycle, echo time and b-value, paving the way for the non-invasive assessment of glymphatic flow in clinical practice.
08:47		Screen Number: 17 0465. Neurovascular decoupling is associated with glymphatic system dysfunction in patients on dialysis W. Yang, L. Song, M. Li, X. Bai, B. Xu, H. Wang, Z. Wang Department of Radiology, Beijing Friendship Hospital, Capital Medical University , Beijing, China Impact: This research highlights critical interactions between neurovascular coupling and glymphatic system function, providing insights that could inform therapeutic strategies for cognitive impairment in dialysis patients.
08:49		Screen Number: 18 0466. First in human evaluation of non-invasive cranial nerve stimulation: DTI measures change in arterial perivascular space and nearby parenchyma View Presentation Video R. Moskwa, K. Cheng, W. Block, C. Minar, J. Williams, K. Ludwig University of Wisconsin-Madison, Madison, United States Impact: Using DTI, external neuromodulation designed to induce changes in cerebrovascular pulsations in humans was shown to cause changes in perivascular spaces near brain arteries and nearby parenchyma, suggesting possibility for neuromodulation devices to serve therapeutic purpose for augmenting glymphatic clearance.
08:51		Screen Number: 19 0467. Investigation of Glymphatic Biomarkers and Structural Gray Matter Integrity in Cognitive Impairment Using DTI Metrics, DTI-ALPS, and gBOLD-CSF View Presentation Video H. Lee, J-H Kim, Y. Lee, S. Park, K. Yuk, S. H. Choi Seoul National University Graduate School, Seoul, Korea, Republic of Impact: These findings highlight the link between glymphatic dysfunction, CSF circulation, and neurodegeneration, offering clinicians and scientists potential biomarkers for early detection. This study paves the way for further research into therapeutic strategies targeting brain clearance systems to mitigate cognitive decline.
08:53		Screen Number: 20 0468. Synthesis of CSF fraction map using deep neural networks and exploration of its potential application in assessing glymphatic dysfunction View Presentation Video G. Lee, S-H Oh Hankuk University of Foreign Studies, Yongin, Korea, Republic of Impact: Our method reduces the requirements to acquire additional multi-echo spin-echo T₂w images for CSFF analysis. This may enhance the utility of CSFF analysis for assessing the dysfunction in the glymphatic system.
08:55		Screen Number: 21 0469. Cardiac active PVS: a metric derived from dynamic T2-weighted EPI for brain effective perivascular space characterization View Presentation Video F. Jiang, T. Hua, Q. He, Z. Wang, S. Tan, L. Chai, Y-c Hsu, X. Zhang, Y. Liu, R. Bai College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China Impact: Our proposed method provides with a new way to characterize these MRI-invisible but cardiac-active PVS density, which is a highly promising biomarker to evaluate the glymphatic system in future.
08:57		Screen Number: 22 0470. The feasibility of mean apparent propagator (MAP)-MRI for Assessing the Glymphatic function View Presentation Video Q. He, Z. Li, J. Liu, Y. Han, E. Özarslan, R. Bai School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China Impact: Given the significant role of the glymphatic system in maintaining brain homeostasis, our findings suggest MAP-MRI’s sensitivity to glymphatic function, which makes it a potentially viable method for monitoring glymphatic activity.
08:59		Screen Number: 23 0471. Assessment of Cerebrospinal Fluid Dynamics During Normal Breathing and Valsalva Maneuver using Real-Time MRI View Presentation Video M. Karamzadeh, M. M. Al Samman, R. Bhadelia, Y. Zhao, J. Oshinski, F. Loth Northeastern University, Boston, United States Impact: Reduction in CSF flow during Valsalva, followed by rapid recovery, may explain the quick resolution of Valsalva headaches in Chiari Malformation. However, the cause remains unclear, as no differences in CSF flow changes were observed between Chiari and healthy groups.
09:01		Screen Number: 24 0472. High-resolution in-vivo imaging of glymphatic markers in frontotemporal lobar degeneration using CSF-STREAM at 7 Tesla View Presentation Video M. Debiasi, F. Prinse, C. Najac, M. J. van Osch, J. van Swieten, L. van der Weerd, E. Dopper, L. Hirschler C.J. Gorter MRI Center, Radiology, Leiden University Medical Center, Leiden, Netherlands Impact: The use of CSF-STREAM to study impaired brain clearance may benefit the understanding of FTLD, in particular by studying PVS properties in different stages and subtypes of the disease.
09:03		Screen Number: 25 0473. Assessment of Slow Flow in the Brain using SCIMI and q-aMRI on a High-Performance Gradient System: Comparison of Phase and Magnitude-based Methods View Presentation Video A. Ajala, I. Terem, I. Heukensfeldt Jansen, N. Abad, C. Bhushan, T. Foo, J. K. DeMarco, R. Shih, G. Kohls, H. D. Morris, A. Pollatou, H. Yalewayker, M. Hood, S. Skeete, E. Metzger, V. Ho, S. Holdsworth, J. K. Warner, K. Setsompop, L. Marinelli GE HealthCare, Niskayuna, United States Impact: This study independently compared the measured displacement fields due to brain parenchymal fluid flow obtained from the SCIMI and q-aMRI methods and the correlation of both estimations, thereby validating both methods and providing deeper insights for applications in neurodegenerative pathologies.

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