ISMRM25 - Basic to Clinical Neuroscience in Pediatrics

ISMRM & ISMRT Annual Meeting & Exhibition • 10-15 May 2025 • Honolulu, Hawai'i

Basic to Clinical Neuroscience in Pediatrics

Power Pitch

Pediatrics

Wednesday, 14 May 2025

Power Pitch Theatre 2

08:15 - 10:15

Moderators: Noriko Aida & Duan Xu

Session Number: PP-19

No CME/CE Credit

08:15		Screen Number: 26 0845. Preclinical 1H MRS Study of a Porcine Model Shows Evidence and Mechanisms for Neuronal Injury in Neonatal Cardiopulmonary Bypass Surgery View Presentation Video A. Omon, D. Spielman, M. Gu, R. Hurd, K. Riemer, F. Hanley Stanford University School of Medicine, Stanford, United States Impact: Understanding how different surgical approaches affect patient outcomes will enable clinics to implement safer protocols for neonates with congenital heart disease, who face a greater risk of neurodevelopmental delays from these critical procedures.
08:17		Screen Number: 27 0846. Lactate and Hypothermia: A Dual Approach for Neuroprotection in Neonatal Hypoxia-Ischemia View Presentation Video A-K BOUZIER-SORE, I. Omar, H. ROUMES, C. PERROT, P. GOUDENECHE, J-F CHATEIL, M-C BEAUVIEUX, O. TANDONNET, L. PELLERIN CRMSB, Bordeaux, France Impact: Lactate administration showed neuroprotection in NHI. Our retrospective clinical evaluation tracking blood parameters during sodium L-lactate infusion in preterm infants confirmed the safety of lactate administration, even with elevated lactatemia at birth, indicating promising potential for clinical pediatric applications.
08:19		Screen Number: 28 0847. Multi-parametric MRI assessment of white matter injury in premature neonatal rats PDF Poster View Presentation Video W. XiaoLi, W. Xizhen, G. Xiaotian, L. Zhen, Z. HaiMo, Z. XiaoZu, C. YongJun, P. Wu Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China Impact: After PWMI in neonatal rats, cerebral blood flow and blood oxygen levels are low, disrupting the intracerebral microenvironment. This inhibits the proliferation and differentiation of cerebral OPCs in PWMI rats, leading to cerebral white matter injury.
08:21		Screen Number: 29 0848. GABA and glutamate changes over time in children with migraine View Presentation Video T. Bell, L. Cho, J. Kuziek, K. Millar, M. Stokoe, A. Hershey, S. Orr, A. Harris University of Calgary, Calgary, Canada Impact: This longitudinal study demonstrates a role for changes in thalamic GABA levels over time in migraine burden in adolescents, providing new evidence for a role of GABA in migraine onset and progression, and a potential opportunity for new treatment targets.
08:23		Screen Number: 30 0849. Novel MRI sequence-agnostic deep learning model to localize seizure onset zone in pediatric drug-resistance epilepsy View Presentation Video J-W Jeong, S. Banerjee, M-H Lee, M. Dong, E. Asano, C. Juhasz Wayne State University, Detroit, United States Impact: Sequence-agnostic learning approach could accurately classify seizure onset zone (SOZ) using clinical MRI sequence data of pediatric drug-resistant epilepsy. It provided a new way to better generalize the SOZ classification in multi-center studies that suffer from missing sequence data problem
08:25		Screen Number: 31 0850. Ultra-high field quantitative susceptibility mapping of the neonatal brain View Presentation Video C. Casella, K. Vecchiato, A. S. Dokumaci, P. Bridgen, P. Di Ciò, I. Tomazinho, C. Da Costa, D. Gallo, J. Willers Moore, J. Hajnal, D. Edwards, J. Sedlacik, K. Shmueli, T. Wilkinson, R. Tomi-Tricot, D. Carmichael, J. O’Muircheartaigh, S. Malik, T. Arichi King's College London, London, United Kingdom Impact: 7T QSM is feasible and sensitive to iron deposition in the neonatal brain, offering potential for early detection of iron-related developmental markers. This approach may improve understanding of prematurity’s effects on brain iron and future neurodevelopment.
08:27		Screen Number: 32 0851. Feasibility of Ultra- Low-Field MRI for Measurement of Regional Infant Brain Volumes in Structures Associated with Anaemia View Presentation Video J. Ringshaw, N. Bourke, M. Zieff, C. Wedderburn, C. Casella, L. Bradford, S. Williams, D. Herr, M. Miles, J. O’Muircheartaigh, C. Bennallick, D. Stein, D. Alexander, D. Jones, S. Williams, K. Donald University of Cape Town, Cape Town, South Africa Impact: This study demonstrates high comparability between ultra- low-field (64mT) and high-field (3T) volumes for brain regions implicated in antenatal maternal anaemia. Findings validate the use of the Hyperfine scanner for paediatric neuroimaging work on anaemia across low- and middle-income countries.
08:29		Screen Number: 33 0852. Structural Covariance Network Analysis Reveals Altered Brain Development in Neonates with Congenital Heart Disease After Surgery View Presentation Video M. van der Meijden, B. Gal-Er, D. Cromb, S. Wilson, A. Chew, A. Egloff, K. Pushparajah, J. Simpson, J. Hajnal, A. D. Edwards, M. Rutherford, J. O’Muircheartaigh, A. Bonthrone, S. Counsell King's College London, London, United Kingdom Impact: Structural covariance network analysis, a data-driven approach to characterise networks of simultaneously developing brain regions, identified 12 networks that were significantly different in neonates with CHD after cardiac surgery compared to healthy neonates, highlighting altered brain development in this population.
08:31		Screen Number: 34 0853. Multivariate Pattern Analysis Reveals Neurobiological Markers of Communication Impairments in Children with Bilateral Spastic Cerebral Palsy H. Jie, H. Cheng, L. Xianjun, N. Lisha, P. Ying, J. Haoxiang, L. Heng, Z. Tijiang Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Engineering Research Center of Intelligent Medical Imaging in Guizhou Higher Education Institutions, Zunyi, China Impact: The MVPA-based model facilitates individualized diagnostics for communication impairments in BSCP, supporting personalized treatment and rehabilitation, and paving the way for precision neuroimaging applications in pediatric neurodevelopmental disorders.
08:33		Screen Number: 35 0854. Added value of perfusion MRI in neonatal arterial ischemic stroke for delineation of biomarker and prediction of remote seizure View Presentation Video W. Wu, S. Agarwal, R. Ichord, H. Huang, M. Ouyang Children's Hospital of Philadelphia, Philadelphia, United States Impact: This study enhances understanding of NAIS by revealing unique perfusion characteristics and developing a predictive model for remote seizure after NAIS. It supports personalized interventions, potentially improving long-term outcomes and guiding future research on NAIS management and outcomes.
08:35		Screen Number: 36 0855. Microstructural geometric alterations in autism: relation with brain network and adaptive function View Presentation Video M. Wang, H. Zhu, D. Xu, B. Peng, Y. Dai, J. Cheng, H. Jiang Department of Radiology, Affiliated Children's Hospital of Jiangnan University, Wuxi, China Impact: White matter microstructural geometry may provide new insights into the neurobiological mechanisms underlying ASD in children, and serve as biomarkers for the prediction of ASD and adaptive function.
08:37		Screen Number: 37 0856. Development of Normative Pediatric Brain Myelin and Iron Atlases and Application to Adrenoleukodystrophy (ALD) View Presentation Video M. Sisman, E. Mallack, A. Roberts, A. Dimov, P. Spincemaille, T. Nguyen, Y. Wang Cornell University, New York, United States Impact: The creation of age- and sex-specific normative pediatric brain atlases of negative and positive susceptibility sources enables the study of spatiotemporal distribution of brain myelin and iron in children under normal neurodevelopment and in various clinical conditions.
08:39		Screen Number: 38 0857. Individualized Parcellation of Precentral Gyrus in Cerebral Palsy Based on Structural Connectivity and Non-negative Matrix Factorization View Presentation Video Z. Wei, Y. Bian, Z. Jia, G. Wang, J. Yang, X. Li the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Impact: We further refined the segmentation results of the precentral gyrus brain area, clarified the impact of cerebral palsy on each subregion, provided new ideas for TMS target optimization, and helped to improve the efficacy of motor rehabilitation in CP children.
08:41		Screen Number: 39 0858. Audiovisual speech integration in children born preterm: a behavioral and fMRI study View Presentation Video M. Durand-Ruel, M. Cascioli, P. Hüppi UNIGE, Geneva, Switzerland Impact: This study uses a new protocol to investigate audiovisual speech integration in a vulnerable population using functional magnetic resonance imaging. This is the first study using fMRI in preterm children to investigate this question.
08:43		Screen Number: 40 0859. Metabolic Insights and Diagnostic Potential of Multi-pool CEST MRI in Neonatal Hypoxic-Ischemic Encephalopathy: a pilot study X. Zhuang, Y. Wu, K. Jin, J. Li, H. Zhang Hunan Children's Hospital, Changsha, China Impact: Multi-pool Lorentzian fitting method offers detailed metabolic information, potentially serving as an indicator for HIE diagnosis, monitoring, and prognosis.
08:45		Screen Number: 41 0860. Functional Connectivity Alteration in Motor Network in the Adolescent Brain Following Neonatal Intermittent Hypoxia View Presentation Video Y-W Sung, C-F Lu, B-Y Hsieh, C-C Huang, Y-C Jill Kao National Yang Ming Chiao Tung University, Taipei, Taiwan Impact: Our findings suggest the alteration in the motor network following neonatal intermittent hypoxia (IH) may last during adolescence. This underscores the necessity for longitudinal study to investigate long-term impairment following neonatal IH, informing potential interventions for affected individuals.
08:47		Screen Number: 42 0861. Altered Cortico-Cerebellar Effective Connectivity of the Visuo-Attention System is associated with READ1 deletion in Developmental Dyslexia View Presentation Video G. Korkmaz, R. Lorenzi, V. Lampis, D. Peruzzo, F. Arrigoni, D. Pischedda, E. D’Angelo, F. Palesi, S. Mascheretti, C. Gandini Wheeler-Kingshott University of Pavia, Pavia, Italy Impact: Our approach of combining imaging with genetics demonstrates that effective connectivity between cortico-cerebellar regions involved in attention is essential for reading ability and that genetic alterations impact on the excitatory strength of such connections, providing possible targets for neuro-modulatory interventions.
08:49		Screen Number: 43 0862. Quantitative evaluation of neurocutaneous melanosis using 3D MR fingerprinting View Presentation Video M. Umehana, Y. Fushimi, M. Sakamoto, T. Yoshida, S. Okuchi, S. Otani, A. Sakata, T. Yamamoto, S. Nakajima, S. Ikeda, S. Ito, Y. Ma, S. Morooka, N. Morimoto, Y. Nakamoto Kyoto University Graduate School of Medicine, Kyoto, Japan Impact: This study introduces a quantitative MR fingerprinting method for assessing neurocutaneous melanosis (NCM), improving diagnostic accuracy and objectivity, and supporting early, precise identification of melanosis, which may enhance understanding and management of NCM.
08:51		Screen Number: 44 0863. Enhanced Quantitative Susceptibility Mapping of Preterm Infant Brains via Nonlinear Total Field Inversion and Multi-parameter Regularization View Presentation Video J. Cheng, Z. Xu, C. Wang, M. Xu, L. Zhu, L. Lin, Y. Zhang, Y. Feng, J. Cheng The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Impact: Preliminary applications in preterm infants indicate that proposed approach can successfully model the essential spatiotemporal evolution of susceptibility. This advancement holds promise for establishing a framework for tracking brain maturation in preterm-populations, setting a new way in early neurodevelopmental assessment.
08:53		Screen Number: 45 0864. Neuroimaging Subtypes in Adolescents with Insufficient Sleep Time Shows Distinct Trajectories of Altered Cortical Thickness View Presentation Video Y. Chen, M. Li, H. Xu, Z. Zhao, Y. Huang, G. Wang, D. Wu Department of Biomedical Engineering, Zhejiang University, Hangzhou, China Impact: We identified three distinct effect patterns of insufficient sleep on cortical thickness with unique sleep behaviors, disease comorbidity, cognitive function, and academic performances. These findings contribute to a comprehensive understanding of the impact of insufficient sleep on adolescent development.
08:55		Screen Number: 46 0865. Sex-specific cerebrovascular reactivity differences related to functional connectivity in autistic children View Presentation Video Q. Lee, J. Lee, P. Liu, D. Harvey, C. Nordahl, A. Fan University of California - Davis, School of Medicine, Davis, United States Impact: Our study highlights potential differences in cerebrovascular function in autism that could improve our neurobiological understanding of autism-related FC changes and inform new targets for intervention.
08:57		Screen Number: 47 0866. Structural correlates of Executive Functions in children born moderate-to-late preterm and full-term View Presentation Video J. Sa de Almeida, L. Rossetti, C. Gilchrist, R. Mainzer, P. Hüppi, M. Seal, P. Anderson, D. Thompson, J. Cheong University Hospitals of Geneva, Geneva, Switzerland Impact: Regional microstructure relates to Executive Functions outcomes, with increased cortical diffusivities linked to poorer outcomes, while increased subcortical diffusivities relate to better performance. Moderate-to-late preterm birth results in increased cortical diffusivity in EF-related regions, impacting attentional control and cognitive flexibility.
08:59		Screen Number: 48 0867. Alterations of glymphatic transport in hypoxic-ischemic encephalopathy were assessed using dynamic contrast-enhanced MRI. View Presentation Video j. shen, y. yang, f. chen, y. zuo, y. yang, w. wei, y. liu, j. wen University of Science and Technology of China, hefei, China Impact: This study identifies impaired glymphatic transport in neonates with HIE, leading to decreased CSF influx and interstitial fluid stagnation. Understanding these mechanisms may inform therapies to enhance glymphatic clearance and improve long-term neurodevelopmental outcomes for affected neonates.
09:01		Screen Number: 49 0868. Longitudinal Brain Morphometry and NIH Toolbox Performance in Adolescents Before and After COVID-19 View Presentation Video M. Ryan, P. Rodriguez Rivera, H. Liang, A. Isaiah, T. Ernst, L. Chang University of Maryland School of Medicine, Baltimore, United States Impact: SARS-CoV-2 infected >16 million US children and may impact their brain development. We found morphometric abnormalities in adolescents with COVID-19, which necessitates further evaluation of long-term effects on brain development trajectories and possible interventions to mitigate cognitive consequences.
09:03		Screen Number: 50 0869. Dynamic Shifts in Controllability of White Matter Networks in Early Brain Development View Presentation Video S. Nguyen, K. Huynh, G. Lin, S. Ahmad, P-T Yap University of North Carolina at Chapel Hill, Chapel Hill, United States Impact: We found that as children grow, brain networks become more controllable on average but less synchronized. Regions with high average controllability generally have low modal controllability, and more synchronized brain networks usually show lower average controllability.

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